A Method to Convert Single Base Changes to Large DNA Differences for Accurate and Sensitive Detection

In cancer and other human diseases, single-base mutations have an important role and can be used as markers for diagnostic tests. Unfortunately, in clinical samples small numbers of mutant cells are often mixed with a vast excess of wild-type cells. Therefore, that is very important to develop sensitive and accurate methods for detection of point mutations. JHU scientists developed an assay for sensitive detection and accurate quantification of viruses and cells with single-base mutations. Description (Set) 1. Simple, universal strategy for sensitive detection and quantification of single-base differences. 2. This method can be used for early detection of � cancer, � cancer minimal residual disease testing, � infectious disease: viral (e.g. HIV, HCV, etc) minority variant detection, � samples containing rare alleles, � bone marrow transplantation engraftment monitoring, � known parental point mutations in maternal peripheral blood. Proposed Use (Set) 1. Research tool to detect a point mutation or single nucleotide polymorphism containing DNA. 2. Diagnosis of genetic disorders and management of patients with cancer and infectious diseases. Patent (Set) WO2005/092038

Inventor(s): Eshleman, James Richard

Type of Offer: Licensing

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