4D Digital Mouse Whole Body (MOBY) Phantom

The 4D digital mouse whole body (MOBY) phantom is a realistic and flexible model of the mouse anatomy and cardiac and respiratory motions for use in molecular imaging research. The organ shapes are modeled with non-uniform rational b-spline (NURBS) surfaces, which are widely used in 3D computer graphics. High-resolution 3D magnetic resonance microscopy (MRM) data obtained from Duke Center for In Vivo Microscopy was used as the basis for the formation of the surfaces. With its basis upn actual imaging data and the inherent flexibility to model anatomical variations and involuntary motions such as the cardiac and respiratory motions. These motions were modeled using a gated black-blood magnetic resonance imaging (bb-MRI) dataset of a normal mouse as the basis for the cardiac model and respiratory-gated MRI and known respiratory mechanics as the basis for the respiratory model, using images botained from the University of Virginia. In each case, the time-changing 3D surfaces are defined by a set of time curves to create time continous dynamic or 4D NURBS surface models. NURBS are an efficient and flexible way to accurately describe the anatomy and cardiac and respiratory motions for a realistic 4D digital mouse phantom. The MOBY phantom provides a unique and useful tool in molecular imaging research, especially in the development of new imaging instrumentation, image acquistion strategies, and image processing and reconstruction methods. Description (Set) Proposed Use (Set) Phantom software for research of molecular imaging systems and image processing, reconstruction and compensation methods. Software to teach mouse anatomy and physiology.

Inventor(s): Segars, William Paul

Type of Offer: Licensing



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