Immune Modulation Through Targeting of the MINOR Gene
this gene will induce apoptosis in dendritic cells, thereby limiting immune responses. Inhibition of the gene will prevent dendritic cell death, thereby enhancing immune responses. Dendritic cells are critical to the initiation of the immune response, thus this will provide a central tool to manipulate immune function. Description (Set) Proposed Use (Set) In addition to therapeutic uses, dendritic cells are used as diagnostic tools to monitor or test the ability of immune cells to generate responses to stimuli.
Whartenby, Katherine Ashley
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