A Multifunctional Intermediate for Imaging PSMA
The present invention includes a novel Prostate Specific Membrane Antigen (PSMA) intermediate. This molecule can be functionalized to become either a nuclear, optical, or magnetic resonance based imaging agent as well as radiohalogen or radiometal therapeutic agents. The PSMA imaging agent can be additional used to image psychiatric disorders in addition to cancers. Background Prostate-specific membrane antigen (PSMA) is a small protein molecule up-regulated in the vast majority of prostate cancers. PSMA has been extensively studies as a potential imaging and therapeutic target in the treatment of prostate and other cancers. Description (Set) Proposed Use (Set) Commercially, this invention is advantageous as it can be functionalized for use in multiple modalities. Furthermore the agent can be used in the operating room to define the tumor margins, thereby aiding in a more complete tumor resection. PSMA is a widely common antigen, therefore the imaging agent can be used to detect and diagnosis a wide variety of disease and cancers including kidney cancer and psychiatric diseases.
Mease, Ronnie C.
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