Transcaval Mesenteric Venous Anastomosis and Access System

This device is used to create a percutaneous anastomosis between the Inferior Vena Cava (IVC) and the mesenteric/portal system. The subsequent anastomosis can be used to divert blood flow for the reduction of portal hypertension; and provide access into the mesenteric, portal, and splenic system for local drug or cellular delivery. The device is composed of a Nitinol based skeleton; therefore it provides feasibility for MR guided percutaneous access to the portal system. A transjugular intrahepatic portosystemic shunt (TIPSS) is a percutaneous connection between the mesenteric/portal system and the Inferior Vena Cava (IVC) within the liver. TIPSS is used to reduce the pressure in the portal system in patients suffering from hypertension by diverting blood flow around the liver. TIPSS procedures risk high occlusion and high encephalopathy rates. Alternatively, a portacaval shunt provides high patency. However portacaval shunts have been largely abandoned due to risk of surgical complications. The present invention provides a percutaneous technique that simulates the surgical shunt. Description (Set) Proposed Use (Set) This device will create a permanent access into the isolated mesenteric system which will allow for potential image guided therapeutic opportunities for target organs such as the pancreas, liver, and spleen. Examples include islet cell transplantation or cellular therapies such as stem cell delivery.

Inventor(s): Karmarkar, Parag V.

Type of Offer: Licensing

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