Co-assembling Peptide Hydrogels

Peptide-based hydrogels have become popular for biomedical applications such as tissue engineering and drug delivery due to their biodegradable and bioresorbable properties. For use in vivo, hydrogels should assemble easily in a controlled fashion and be compatible with native entrapped biomolecules. A novel peptide-based hydrogel (which is 99.7 % water by weight) has recently been created that assembles by simple mixing of two peptide solutions. Novel features of this hydrogel include shear responsiveness, the ability to regain mechanical strength following breakage with shear forces, and the ability to encapsulate proteins in their native form. Description (Set) Proposed Use (Set) Existing products in the hydrogel market fall short of the ideal material properties desired in a peptide hydrogel system as they can suffer batch to batch variability, low protein solubility or unwanted aggregation or gelation. The novel invention described here addresses these shortfalls and possesses properties that are highly desirable for injectable biomaterials in tissue engineering and drug delivery applications.

Inventor(s): Tseng, Yiider

Type of Offer: Licensing



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