Chest Pain Differentiation Serum Diagnostic Panel (CPDP)
Abstract (Set) Patients presenting at an emergency room with acute chest pain are likely to be evaluated for acute coronary syndrome (ACS), pulmonary embolism (PE), aortic dissection (AD) and other less fatal conditions, all of which have indistinguishable symptoms. Although rapid diagnosis and appropriate treatment is critical to the patient?s life, current diagnostic tests such as high resolution CT scanning and ventilation perfusion scanning are time-consuming and low in diagnostic yield. Scientists at JHU have now developed a novel diagnostic alternative: a quick high through-put proteomics-based panel that can differentiate between ACS, PE and AD and non-vascular chest syndromes. The invention is based on the systematic difference in the concentration of a panel of cytokines, chemokines and protein biomarkers that differentiates ACS, PE and AD. Description (Set) Proposed Use (Set) Approximately 2,125,000 patients are hospitalized in the US each year for coronary heart disease and 99,000 patients for pulmonary embolism. Many millions of others present to the emergency room with heart pain, the cause of which is benign or non-vascular. The innovative Chest Pain Differentiation Panel (CPDP) could be developed by interested companies to provide quick diagnosis of these syndromes, more reliable treatment decisions and improved patient outcomes. The panel will also provide a cost savings over diagnostics techniques employed by emergency rooms at the current time.
Van Eyk, Jennifer
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