Diagnostic Assays for a Polymorphism in a Gene That Affects Cardiovascular Health
High density lipoproteins (HDL) are considered good or healthy cholesterol that can protect against heart disease. However, there are people who have health problems despite having desirable levels of HDL. There are a number of factors that can contribute to the blood levels of HDL, including genetic problems and lifestyle choices. An invention by JHU researchers has now discovered that a sizeable number of people (approximately 34%) with desirable levels of HDL (defined by the National Cholesterol Education Program guidelines as being above 60 mg/dl) have a variation within a particular gene that leads to lower levels of a protective protein in their cells. Description (Set) Proposed Use (Set) This invention may be developed into a diagnostic assay that identifies a individuals who have a deficiency of an important protective protein that can lead to problems with heart disease and infertility and potentially other problems, such as neurological diseases and hormonal disorders.
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