Biodegradable Polyphosphates for Controlled Release of Bioactive Substances
The present invention includes a series of polycationic biodegradable polymers, the process for making the polymers, and the process for making compositions contain polymers and bioactive ligands. The biodegradable polymers are capable of forming a complex with biological active substances which include but are not limited to DNA, RNA, proteins, and small molecule therapeutics. Furthermore, the polymers of the invention have groups that can facilitate the intraceullar delivery of the biological active substance, achieve selectivity, and enhance gene delivery. The current invention also provides a complex composition with buffering capacity. Background Because of the limitations of current viral vectors, lipids, and cationic polymers current research has focused on alternative polymer based gene delivery systems. Polymer based methods of gene delivery have been promising for ex vivo and in vivo experiments. Polymers tend to be less pathogenic than viral vectors and have reduced toxicity. The present invention includes a series of polycationic biodegradable polymers, the process for making the polymers and compositions contain polymers and bioactive ligands. Description (Set) Proposed Use (Set) Polymer based delivery systems of gene or small molecule therapeutics are currently a growing alternative to viral based delivery vectors. Polymers tend to be less pathogenic and sustain reduced immune response. The current technology is versatile and can be used for a broad range of gene delivery or small molecule therapeutic applications.Inventor(s): Leong, Kam W
Type of Offer: Licensing
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