Biomarkers Differentially Expressed in Ovarian Cancer Cells with Deactivation of the MAPK Pathway
Abstract (Set) Activation of the MAPK signaling pathway has been implicated in many human cancers. Scientists at JHU have discovered that the expression profile of two biomarkers in the ovarian cancer cell line MPSC1 is regulated by the deactivation of the MAPK pathway. Through real-time PCR, they further observed the regulatory effect at the transcriptional level. Description (Set) Proposed Use (Set) The discovery provided interesting insight into cancer biology. The two biomarkers have the potential to be novel diagnostic and therapeutic targets for cancers with MAPK mutations.
Zhang, Zhen ,Chan, Daniel,Sun, Xiaer
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