Tau-nY29: Monoclonal Antibody Specific for Tau Nitrated At Tyrosine 29 (27006
A mouse monoclonal antibody (IgG1) to detect nitration in a protein-specific and site-selective manner. This antibody recognizes tau only when nitrated on residue Tyr29. It does not cross react with wild type tau, tau mutants singly nitrated on Tyr18, Tyr197, and Tyr394, or other proteins known to be nitrated in neurodegenerative diseases.
SIGNIFICANCE: Tau-nY29 is a biologically selective, site-directed antibody that detects tau nitration exclusively at the Tyr29 position. Using this reagent, Northwestern researchers demonstrated that nitration at Tyr29 is a disease-related event that may influence the ability of tau to self-associate. In addition, whereas Tau-nY29 stains the fibrillar tau lesions in Alzheimer’s disease (AD) brain, it differentially labels glial and neuronal tau inclusions in the non-AD tauopathies. This latter finding suggests that, during the progression of diverse tauopathies, differential posttranslational modifications may alter the biochemical properties of tau, leading to markedly dissimilar pathological and clinical phenotypes.
Northwestern University is interested in licensing this antibody as a research reagent.
REFERENCES: The generation and characterization of the tau-nY29 antibody is detailed in J Neurosci. 2006 Oct 18;26(42):10636-45.
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