Mouse Null for Pigment Epithelium-derived Factor (PEDF) (21077)
Investigators at Northwestern University created an animal model useful for analyzing the role of pigment epithelium derived factor (PEDF), an endogenous inhibitor of angiogenesis, in the onset and progression of diseases of the prostate, eye and brain. This heterozygous PEDF mouse represents the only currently available biological model for benign prostatic hyperplasia. Furthermore, the PEDF null mice show abnormalities in multiple tissues including the prostate, retina, kidney, and cerebellum. This is the first transgenic animal null for PEDF expression.
ADVANTAGES: This mouse model is a valuable tool to investigate role of PEDF in development. The PEDF-null mouse is also of use as a biological background to investigate PEDF and/or PEDF mimetics. The heterozygote is a tool to test therapies for benign prostatic hyperplasia. The homozygous mice are models to study neovascularization-driven ocular diseases including diabetic retinopathy and macular degeneration.
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