Tau-13 Monoclonal Antibody (20081)
Tau-13 is a mouse monoclonal antibody (mAb) that binds to human tau as demonstrated by ELISA and immunoblot assays and is able to stain brain tissue early in Alzheimer’s disease. The Tau-13 mAb would be useful to researchers who wish to detect human tau in solid phase assays as it has a remarkably high affinity for the immunogen. This antibody is useful in tissue staining and may be used for pull-down assays.
ADVANTAGES: The Tau-13 mAb was derived from a hybridoma cell line created through the fusion of SP2/o myeloma cells with splenocytes from a mouse immunized with the polymeric form of the longest human tau isoform. The hybridoma cell line was subcloned four times and stored in frozen liquid nitrogen. Tau-13 is specific for human tau; it does not react with bovine, murine or rat tau. The antibody is of the IgG1 subtype. Preliminary assignment of its epitope indicates that it maps to amino acid residues 2-18 on the longest isoform of human tau.
Northwestern University is interested in licensing this antibody as a research
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