Surface Functionalization of Polymers for Drug Delivery
Background Currently, wet chemical conjugation and simple adhesion are used to achieve surface functionalization of biodegradable polymer particles. Unfortunately, both of these methods have poor reproducibility, they are inefficient, and they have complex processing requirements and toxicity issues associated with the chemicals used to modify the polymers.
Invention Description This technology represents a biodegradable polymer for the controlled delivery of drugs and vaccines that makes use of atmospheric-pressure glow (APG) plasma. By utilizing APG plasma, functionalization occurs on the exposed surface area of the polymer. This unique plasma works by allowing particle suspension in the gas phase, which in turn allows the surface particles to be charged and chemically functionalized. Further processing allows particular proteins, nucleic acids, contrast agents, or drugs of interest to be incorporated into the polymer.
Efficient High throughput Cost effective No need for high vacuum or high temperature Safer alternative because no surfactants used No structural damage to particle surface Environmentally friendly
Entire exposed surface area is functionalized Enables continuous processing of particles Plasma-based processing technique Low ion impact energies Room temperature and atmospheric pressure operation
Market Potential/Applications This technology can be applied to tissue engineering, prosthesis, and even non-biomedical applications.
IP Status One U.S. patent application filed
UT Researcher Krishnendu Roy, Ph.D., Biomedical Engineering, The University of Texas at Austin Laxminarayan L. Raja, Ph.D., Aerospace Engineering and Engineering Mechanics, The University of Texas at Austin
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