3-Dimensional Bioconstruction Techniques to Connect Electronic and Biological Systems
Background Bioelectronic interfaces hold great promise for medicine and research; however, current fabrication methods of electronic or electroactive materials involve expensive lithographic masks, complicated stamping, and chemical etching. The assemblies produced are inherently 2-D and have not proven useful for creating complex 3-D assemblies. The current manufacturing methods for electroactive materials often used as interfaces with biological cells and tissue are limited by the fact that they must be fabricated before the introduction of the biological material.
Invention Description This is an innovative strategy for microfabrication of electronic materials that can be performed under aqueous conditions promoting compatibility with biological molecules and living cellular systems. These materials offer unique opportunities for in situ placement of electronic and electrochemical inputs/outputs for communicating with biological systems including potential use in the processes of bioassays, bioenergy harvesting, promoting cellular differentiation, manufacturing tissue scaffolds, and neuronal regeneration.
Manufacturing process is compatible with biological systems Allows for in situ fabrication of structures Can fabricate biocompatible submicron 3-D structures Complex, multicomponent sensors can be synthesized Freeform fabrication Can fabricate bioenergy harvesting and cellular interfacing platform assemblies
This invention represents a strategy for microfabricating electronic and electroactive materials. The use of direct-write lithography technique offers exceptional promise as a more direct assembly protocol for fabrication of functional bioelectronic elements. This technique allows for amend ability to accommodate complex shape, structures, and different material assembly chemistries
Market Potential/Applications This technology relates to some of the fastest growing research and commercialization areas and could appeal to companies involved with: microsurgery tissue engineering microfluidics - sustained release and biosensing devices
Development Stage Proof of concept
IP Status One U.S. patent application filed
UT Researcher Jason B. Shear, Ph.D., Chemistry and Biochemistry, The University of Texas at Austin Ryan T. Hill, BS, Chemistry and Biochemistry, The University of Texas at Austin Keith J. Stevenson, Ph.D., Chemistry and Biochemistry, The University of Texas at Austin Jennifer L. Lyon, BS, Chemistry and Biochemistry, The University of Texas at Austin
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