A Novel Preparation of Pyrroles from Nitriles and Cyclopropanes
Background The new use of known materials to prepare pyrroles in a highly efficient and selective manner is the nature of the discovery.Invention Description A new method for the synthesis of pyrroles from nitriles and cyclopropanes is described. Pyrroles have found applications as pharmaceuticals, biological probes, molecular receptors for anions and cations, as dyes (including fluorescent dyes), charge transfer agents, conductive materials, polymers and polymer additives, non-linear optical materials, and electroluminescent devices. The described method simplifies the preparation of some pyrrole classes which find use in many of these applications. The method will offer access to structures that are otherwise difficult or expensive to prepare, thus facilitating the use of new pyrroles in unique ways. Furthermore, the synthetic method supported by this invention is flexible and offers access to some pyrroles that are otherwise difficult to prepare by standard methods.
Benefits
Flexible, and offers access to some pyrroles that are otherwise difficult to prepare by standard methods More efficient than existing methods of preparing specialized pyrroles Convenient Starting materials are readily available
Features
Absolute control over substituents at C(2), a feature of the invention that reflects the use of a nitrile precursor. Ability to control the substituent at C(2) in a way that provides unambiguous differentiation from C(5)
Ability to introduce new functional groups not compatible with reaction conditions using current methodologies.
Market Potential/Applications Applications include: pharmaceuticals, biological probes, molecular receptors for anions and cations, as dyes (including fluorescent dyes), charge transfer agents, conductive materials, polymers and polymer additives, non-linear optical materials, and electroluminescent devices.
IP Status One U.S. patent issued: 7,034,163
UT Researcher Brian L. Pagenkopf, Ph.D., Chemistry and Biochemistry, The University of Texas at Austin Ming Yu, Chemistry and Biochemistry, The University of Texas at Austin
Type of Offer: Licensing
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