Insulin Receptor Knockout Mice
Description: The Insulin/IGF family of ligands and receptors controls mammalian growth, metabolism and reproduction, and insulin signaling at the insulin receptor is implicated in important signal transduction pathways. Interactions at this receptor can either amplify, diversify or terminate insulin action. One fruitful strategy for studying insulin receptor action is the creation of mouse models in which the gene encoding the insulin receptor has been ablated or knocked out. Clinical & Commercial Utility: The available technology features several lines of knockout mice, engineered to ablate the Insr insulin receptor gene in specific tissues. These mouse models are useful in R&D and drug screening and development for metabolic diseases. Specific phenotypes include: -- Muscle (MIRKO); Dyslipidemia; metabolic syndrome and weight gain. -- Adipocyte (FIRKO); Resistant to weight gain. -- Neuronal (NIRKO); Alzheimer Disease-like symptoms (e.g., tau hyperphosphorylation). -- Liver (LIRKO); Moderate insulin resistance, transient hyperglycemia. -- Beta-cell (BIRKO); Impaired glucose tolerance. -- Brown adipose tissue (BATIRKO); beta-cell failure.
These knockout mice lines have been published over the last several years and are reviewed in Kitamura, et al., Ann. Rev. Physiol. (2003) 65:313-332.
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