Regulatory T Cell MEDIATOR PROTEINS and uses thereof
Regulatory T cells (Treg) play an important role in constant and inducible control of T cells responses in vitro and in vivo. Treg cell depletion results in the induction of autoimmune pathology and exacerbation of T cells responses to foreign and self-antigens, including heightened anti-tumor responses as well as ablation of transplantation tolerance and rapid graft rejection.
Dartmouth researchers have now found a novel member of the PD-L1 family expressed by Treg cells. This novel protein has been designated PD-L3. Like other members of the PD-L1 family, PD-L3 co-stimulates αCD3 proliferation of T cells in vitro. In addition, the expression of PD-L3 is increased in αCD3-activated Treg and reduced in the presence of αGITR. A second, TNF-like, protein has also been identified as being upregulated upon αCD3/αGITR stimulation. This protein has been designated Treg-sTNF. These proteins may be involved in contact-dependent and paracrine suppression of immunity and can therefore be used to modulate immune responses and treat diseases and conditions involving Treg signaling.
This technology is claimed in a pending patent application. We are seeking an industrial partner interested in its commercialization.
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