Bioreactor Suite ()
A major drawback of conventional reactors has been gravity-induced sedimentation of the microcarrier beads. As cell density becomes greater, the beads require more stirring, resulting in high shear levels. Batch cultures are limited to the number of cells that can be grown and maintained. Fixed matrix reactor vessels do not allow for homogenous distribution of nutrients or control of the sheer regimes. But the microgravity bioreactor can grow the cells in 3-D spatial freedom while causing low shear stress to the cell. It also encourages critical cell interactions, which allow modeling of in vivo tissue structure.
The bioreactor can be used to grow renal cells and other unique cell types, but it can also be used with in vitro screening and for metabolic, toxicological, anti-infective or other evaluations, as well as for biologics for therapeutic and other diagnostic applications. Some applications that have been underutilized thus far include bone, cancer, heart and cardiovascular, liver, pancreas, microbiology, tissue engineering and prostate research. Another potential use is in neural and nueroendocrine research, which involves the interaction between the nervous system and the hormones of the endocrine glands. The apparatus also can be used for proliferating bone marrow tissues, red and white blood cells and resultant tissues and cells.
The cells grown in the bioreactor can form higher order tissue structure and carcinomas. The device allows for complex cell interrelationships and supports cell proliferation in complex growth media. With the re-supply of oxygen and nutrients and the removal of toxic metabolic waste, it optimizes cell functions.
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