Phase Sensitive Differential Polarimetry Technique and Apparatus

A differential polarimeter is disclosed for detecting changes in optical rotation between a test cell and reference cell. The test cell contains a fluid sample exposed to an analyte specific enzyme; the reference cell contains a fluid sample not exposed to the enzyme. To enhance the sensitivity of the system, a phase-sensitive differential polarimetric technique is taught. In this technique, the phase difference between two resulting sine wave voltages is a measure of analyte concentration.

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