Readily Available Unprotected Amino Aldehydes
A new class of compounds, containing two functional groups, an aldehyde and an unprotected amine has been developed. This finding has solved a significant problem in complex amine chemistry. Construction of complex biologically active molecules is now feasible with minimal use of protecting group manipulations.
These novel molecules contain both a secondary amine functionality and an aldehyde functionality that are stable towards condensation. Accordingly, these derivatives can be utilized in synthetic processes, decreasing the number of steps leading to various nitrogen-containing target molecules.
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