Pestalotiopsis Microspora Isolates and Compounds Derived Therefrom

Endophytic fungi and bacteria are those organisms living within the tissues of host plants. Typically, endophytes coexist with their hosts without any pathogenic symptoms. These organisms have proven to be an unusually rich source of novel bioactive natural products. One of the most ubiquitous endophytic fungi is Pestalotiopsis microspora. This microorganism produces a plethora of bioactive organic substances including the anticancer drug taxol. This technology relates to the novel isolated 12-30 strain of Pestalotiopsis microspora capable of producing antioxidant and antimycotic properties.

This technology provides methods for producing a number of compounds that possess both antioxidant and antimycotic activity. These compounds, designated isopestacin and pestacin, and their derivatives, are able to scavenge free radical oxygen and free radical hydroxyl ion and render them inactive in their destruction action against biological moieties such as proteins and lipids that are vital to normal metabolic functions, such as the destructive action in skin. This technology also provides pharmaceutically acceptable compositions which comprise a therapeutically-effective amount of pestacin, isopestacin and their derivatives

Stage of Development
A utility patent application has been filed with the U.S. Patent and Trademark Office. This technology is part of an active and ongoing research program. It is available for developmental research support/licensing under either exclusive or non-exclusive terms.

Inventor(s): James Harper

Type of Offer: Licensing

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