A Mouse Model of Synovial Sarcoma
The present invention provides the first and only genetic mouse model of synovial sarcoma, a highly aggressive, malignant childhood/young adult soft tissue cancer. This mouse model was generated by conditionally expressing the human SYT-SSX2 fusion protein with myoblasts. It faithfully recapitulates human synovial sarcoma in presentation, histopathology, molecular markers, immunohistochemistry and transcriptional profile.
Currently, the origin and pathogenesis of synovial sarcoma is poorly understood and patients� response to existing therapeutic modalities is unsatisfactorily. This new mouse model should significantly aid our efforts to understand the pathogenesis of human synovial sarcoma and provide us a reliable and easy-to-use preclinical platform in the design and evaluation of novel therapeutic strategies against synovial sarcoma as well other sarcomas that have pathways in common with synovial sarcoma. Also, primary cell cultures obtained from these conditional mice will significantly complement the existing repertoire of in vitro methods to study this cancer. In addition, this model is a valuable tool for new imaging or diagnostic studies.
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Malay Haldar, Mario Capecchi
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