The APC Gene, for Detection and Diagnosis of Inherited and Sporadic Colorectal Cancers
The adenomatous polyposis coli (APC) gene is a tumor suppressor gene which is altered in many colon cancers. Germline mutations of APC are the cause of familial adenomatous polyposis (FAP), an inherited syndrome which leads to the growth of hundreds of colon polyps and a 100% lifetime risk of developing colon cancer. In addition to its importance in familial colon cancer, the APC gene has been found to be mutated or inactivated in 85% of sporadically arising colon cancers, and loss of normal APC function is an important early event in carcinogenesis.The present invention provides methods, probes, and primers for detection of germline and somatic alterations in APC, changes in levels of APC expression and the levels of APC protein, isolated APC cDNA and protein, antibodies directed against wildtype and mutant forms of the APC protein, and methods for diagnosis and prognosis of colon cancer by detecting alterations in the APC gene, mRNA, or APC protein.
Benefits
The adenomatous polyposis coli (APC) gene is a tumor suppressor gene which is altered in many colon cancers. Germline mutations of APC are the cause of familial adenomatous polyposis (FAP), an inherited syndrome which leads to the growth of hundreds of colon polyps and a 100% lifetime risk of developing colon cancer. In addition to its importance in familial colon cancer, the APC gene has been found to be mutated or inactivated in 85% of sporadically arising colon cancers, and loss of normal APC function is an important early event in carcinogenesis.
The present invention provides methods, probes, and primers for detection of germline and somatic alterations in APC, changes in levels of APC expression and the levels of APC protein, isolated APC cDNA and protein, antibodies directed against wildtype and mutant forms of the APC protein, and methods for diagnosis and prognosis of colon cancer by detecting alterations in the APC gene, mRNA, or APC protein.
Stage of Development
Patent numbers 5,352,775; 5,648,212; 5,691,454; 5,783,666; 6,114,124; and 6,413,727 have issued.
The technology is available for licensing under non-exclusive terms.
Additional Info
Raymond L. White - Human Genetics
Susan Carlson - Human Genetics
Inventor(s): Alexander Markham, Mary Carlson, Yusuke Nakamura, Bert Vogelstein, Raymond White, Kenneth Kinzler, Hans Albertsen, Geoffrey Josl, Geoffrey Joslyn, Philip Hedge, Andrew Thliveris, Rakesh Anand, Joanna Groden
Type of Offer: Licensing
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