Diagnostic Test for Equine Hyperelastosis Cutis
The present invention provides a method of diagnosing equine hyperelastosis cutis (HC), an inherited connective tissue disorder of increasing prevalence in Quarter Horses. The diagnostic test includes determining the ratio of urine deoxypyridinoline (DPD) to pyridinoline (PYD) of a subject horse by high performance liquid chromatography, and comparing the ratio of DPD to PYD of the subject horse to a ratio of DPD to PYD of a hyperelastosis cutis-free horse.
Horses affected with HC have extremely fragile thin skin that tears easily and exhibits impaired healing. Conventionally, diagnosis of HC relies on the horse�s lineage and/or the showing of evident clinical signs (e.g., typical cutaneous lesions) after the horse enters training. Unfortunately, by that time, significant emotional and financial investments have been made. This invention demonstrated that horses with HC can be readily identified by a statistical significant increase in the ratio of DPD to PYD in their urine, and thus provides an accurate, convenient, fast, and early diagnostic test for horses affected with HC.
Stage of Development
A US patent has been filed.
This technology is available for licensing under either exclusive or non-exclusive terms.
*Brounts SH, Rashmir-Raven AM, Black SS. (2001) Zonal dermal separation: a distinctive histopathological lesion associated with hyperelastosis cutis in a Quarter Horse. Vet Dermatol. 12(4):219-24.
Marzia Pasquali, Cyrianna Swiderski, Ann Rashmir-Raven
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