Drug Delivery System for Macromolecular Treatment of Arthritis and Other Inflammatory Diseases

The technology in this invention is a water-soluble polymeric drug delivery system for the improved treatment of rheumatoid arthritis and other inflammatory diseases. The delivery system consists of a water-soluble polymer backbone, targeting moieties, and antirheumatic drugs. The polymeric background and the targeting moieties would direct the delivery system specifically to the disease lesions. The uniquely designed linkages that connect the drug to the polymer backbone will be cleaved specifically at the lesions to release the drug. Due to the strong tissue specificity of the delivery system, significantly improved therapeutic efficacy and safety profile have been observed.

Benefits
This technology greatly increases the therapeutic potential and dosing window of the anti-inflammatory drugs by reducing their side effects. Currently available inflammatory drugs such as NSAIDs, Glucocorticoids, Methotrexate, Sulfasalzine, Chloroquine, Gold, Penicillamine, Cyclosporine and various biological compounds can be delivered using the novel system, which also enhances the therapeutic effects of the drugs.

Stage of Development
A PCT patent application has been filed with the U.S. Patent and Trademark Office, and the patent is pending.
This technology is available for developmental research support and licensing under either exclusive or non-exclusive terms

Additional Info
Wang D, Miller SC, Sima, M, Parker D, Buswell, H, Goodrich KC, Kopeckova, P, Kopececk J (2004). �The Arthrotropism of Macromolecules in Adjuvant-Induced Arthritis Rat Model: A Preliminary Study.� Pharmaceutical Research 21(10):1741-49.

Inventor(s): Dong Wang, Jindrich Kopecek, Scott Miller, Pavla Kopeckova

Type of Offer: Licensing



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