Novel Enantiomeric Chiral Alcohols
DESCRIPTION: University of California, Merced (UC Merced) researchers have synthesized novel enantiomeric chiral alcohols, derivatives of a phenyl isobutanol. These compounds feature a conformationally restrictive methyl group on the phenyl group adjacent to the alcohol functionality.
APPLICATIONS: The UC Merced chiral alcohols are potential candidates for chiral auxiliaries, chiral ligands, and alcohol precursors to other types of ligands, such as thiols or amines.
ADVANTAGES: The conformational restrictiveness of these compounds are highly advantageous for applications involving use as a chiral auxiliary or ligand, and could be beneficial in sterically occluding undesired reactions. The synthesis of these compounds involves a one-step procedure with enantiomeric yields >99%.
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