Polymer/metal Complex Composite Having Mri Contrast Ability and Mri Contrasting And/or Antitumor Composition Using the Same

The present invention provides a polymer-metal complex composite, which comprises a block copolymer capable of serving as a constituent member of a polymeric micelle and a metal complex having MRI contrast ability, accumulates in a tumor-specific manner, achieves high image contrast even in a small amount, and has reduced side effects and a long retention time in blood. The polymer-metal complex composite of the present invention comprises a block copolymer (A) represented by general formula (a) and a metal complex (B) having MRI contrast ability, wherein the composite comprises a structure in which a carboxyl anion of poly(carbo) in the copolymer (A) is attached to the metal complex (B) via a metal atom (M).

Under circumstances where the accumulated incidence rate and mortality of cancer keep on increasing, it is a challenge to detect cancer in its early stages at every site. If cancer is detected in its early stages, the risk of invasion during therapy can be reduced and it is also expected that the cancer can be cured completely. Protocols for early therapy have been established for each cancer, and hence there is a demand for simple techniques having high diagnostic ability. Moreover, in the case of a patient who has been diagnosed as having advanced cancer, accurately diagnosing the presence or absence of distant metastasis is very important for determination of the patient's disease stage and the therapeutic strategy required subsequently. Cancer therapies include surgical operations, radiotherapy and chemotherapy. In the case of surgical operations, it is expected that cancer can be cured completely when metastasis lesions are precisely excised or cauterized. Radiation therapy also allows reduction of side effects when tumor sites are precisely determined and selectively irradiated to thereby avoid irradiation in other normal sites. In these senses, accurate diagnosis of cancer sites is very advantageous for cancer patients at all stages of the disease.

Patents:
CA 2,728,960

Inventor(s): KATAOKA KAZUNORI [JP]; KAIDA SACHIKO [JP]; CABRAL HORACIO [JP]; KUMAGAI MICHIAKI [JP]; SEKINO MASAKI [JP]

Type of Offer: Sale



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