Polyion Complex of Double-stranded Ribonucleic Acid

PROBLEM TO BE SOLVED: To provide a delivery system useful for delivering a double-stranded ribonucleic acid that achieves gene silencing in glomeruli, particularly mesangial cells or other cells to the tissues or cells; and others. ; SOLUTION: A polyion complex is in the form of a non-polymeric micelle, which is composed of a double-stranded ribonucleic acid and a block copolymer represented by formulae (I) or (II) electrostatically coupled to each other and has an average particle diameter measured by a dynamic light scattering method of less than 100 nm. The symbols in formulae are specifically defined. ; COPYRIGHT: (C)2011,JPO&INPIT

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Patents:
JP 2,010,233,499

Inventor(s): HORI YUICHI; KATAOKA KAZUNORI; NISHIYAMA NOBUHIRO; FUJITA TOSHIRO; SHIMIZU HIDEKI; OBA MAKOTO; MIYATA KANJIRO; MATSUMOTO SATORU;

Type of Offer: Sale



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