ENVIRONMENT-RESPONDING siRNA CARRIER USING DISULFIDE-CROSS-LINKED POLYMERIC MICELLE
Disclosed is a siRNA-encapsulating polymeric micelle complex (a polyion complex) having high monodispersibility and structural stability and excellent in the ability of transporting siRNA into a cell. Further disclosed are a nucleic acid delivery device, a nucleic acid delivery kit, a pharmaceutical composition, and a gene therapy agent, each of which uses the complex. The polyion complex is characterized by comprising: a block copolymer composed of a polyethylene glycol moiety and a polycation moiety having a thiol group as a side chain at the terminus; and siRNA.
The present invention relates to a polymer micelle complex containing a nucleic acid, and particularly relates to a polymer micelle complex containing siRNA. The present invention also relates to a nucleic acid delivery device, a nucleic acid delivery kit, a pharmaceutical composition and a gene therapy agent, each of which comprises the complex.
KATAOKA KAZUNORI [JP]; NISHIYAMA NOBUHIRO [JP]; MATSUMOTO SATORU [JP]
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