Dimethylthiofoxins and azafoxins which may be useful as ligands for G-protein coupled receptors

The invention provides compounds of general formulae (II) or (III), or pharmaceutically acceptable salts thereof. X is -CO-(Y)k-(Z)nor -SO2-(Y)k-(Z)nwherein k is 0 or 1, each Y is a cycloalkyl, polycycloalkyl, cycloalkenyl or polycycloalkenyl group, n is an integer from 1 to the maximum number of substitutions permissible on the cyclo group Y, each Z is H or various residues or Z may be a peptide radical. R2, R3and R4are independently any substitutent.; The invention also provides methods for preparing the compounds, pharmaceutical compositions comprising the compounds and use of the compounds for the preparation of medicaments intended to modulate the activity of one or more members of the G-coupled receptor (GPCR) class, including adrenaline receptors, endothelin receptors, chemokine receptors, EDG receptors, dopamine receptors, serotonin receptors, purine receptors, metabotropic glutamate receptors, glucagon receptors, acetyl choline receptors, glycoprotein hormone receptors, protease activated receptors, somastostain receptors, angiotensin receptors, cholescystokinin receptors, melatonin receptors.

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