Composite biomaterial formed by cooling a fluid composition on a porous solid and removing solidified crystals of the liquid carrier

A process for the preparation of a composite biomaterial comprising providing a first solid component comprising one or more of collagen, a glycosaminoglycan, albumin, hyaluronan, chitosan, and synthetic polypeptides comprising a portion of the polypeptide sequence of collagen, and optionally an inorganic material, the component having a surface portion that is porous; providing a fluid composition comprising one or more of collagen, a glycosaminoglycan, albumin, hyaluronan, chitosan, and synthetic polypeptides comprising a portion of the polypeptide sequence of collagen, and a liquid carrier, and optionally an inorganic material; contacting the fluid composition with the porous surface portion of the first component; cooling the fluid composition to a temperature at which the liquid carrier transforms into solid crystals or particles; and removing the plurality of solid crystals or particles by sublimation and/or evaporation. The biomaterial may be used to form synthetic bones or teeth. The process may be used to join two solid components by providing the fluid composition between two different solid components.

Attached files:


Patents:
NO 20,091,082

Inventor(s): BONFIELD WILLIAM [GB]; GIBSON LORNA J [US]; YANNAS IOANNIS V [US]; LYNN ANDREW [GB]; WISSNER-GROSS ZACHARY D [US]; HARLEY BRENDA

Type of Offer: Sale



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