Methods of Analysing Homeostatic State in Cell Systems
The invention relates to a method of analysing the homeostatic balance of a population of cells, which includes the following steps: a) label one or more cells in the population b) incubate the cells for a time t c) determine the clone size distribution of labelled cells at time t d) determine if the clone size distribution of (c) conforms to the scaling formula (I): where Pn(t) is the probability of finding a surviving clone which has n progenitor cells at time t, formula (II) denotes the average number of dividing cells in surviving clones at time t and formula (III): wherein if the clone size distribution conforms to the scaling form above, the cells are identified as being in a normal steady-state homeostatic balance; if the clone size distribution does not conform to the scaling form above, the cells are identified as not being in a normal steady-state homeostatic balance.
SIMONS BENJAMIN DAVID [GB]; KLEIN ALLON [GB]; JONES PHILIP HOWLETT [GB]
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