Probes Comprising Fluorescent Artificial Nucleobases and Use Thereof for Detection of Single Base Alteration
The present invention relates to forced intercalation probes (FIT-probes) comprising at least one nucleoside analogue which comprises at least a fluorescent artificial nucleobase directly bound to a carbon of a modified sugar moiety wherein said modified sugar moiety is a carba-sugar or an amino acid nucleic acid (AANA). Thereby the nucleoside analogue is incorporated into DNA or RNA in the place of a single native base.
ARENZ CHRISTOPH [DE]; ROTH ANKE GUNDULA [DE]; UHLIG STEFAN [DE]; DRESCHER DANIELA [DE]
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