Aryl and Vinyl Amination
The invention provides methodology for carbon-nitrogen bond formation via vinyl or aryl amination. An sp2 hybridized radical is reacted with an azomethine moiety to form pyrrolidine and indole compounds.
The invention provides a facile process for the syntheis of compunds having the pyrrolidine or indole subunit and is especially advantageous for compounds having acid or base labile functional groups and/or is comprised of chiral centers susceptible to acid/base epimerization.
Jeffrey N. Johnston and Rajesh Viswanathan
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