Aryl and Vinyl Amination

The invention provides methodology for carbon-nitrogen bond formation via vinyl or aryl amination. An sp2 hybridized radical is reacted with an azomethine moiety to form pyrrolidine and indole compounds.

The invention provides a facile process for the syntheis of compunds having the pyrrolidine or indole subunit and is especially advantageous for compounds having acid or base labile functional groups and/or is comprised of chiral centers susceptible to acid/base epimerization.

US 6,670,479
US 7,078,567

Inventor(s): Jeffrey N. Johnston and Rajesh Viswanathan

Type of Offer: Licensing

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