Method for Monitoring the Dehybridi Zation of Double Stranded Nucleic Acid
The present invention relates, in one aspect, to a method for monitoring the dehybridisation of double stranded nucleic acid, comprising the steps of: (a) providing a nucleic acid probe and a target nucleic acid; (b) forming a double stranded nucleic acid of which at least one of the strands of the nucleic acid is in contact with a solid substrate; (c) applying a potential ramp to the solid substrate; and (d) monitoring the dehybridisation of the double stranded nucleic acid across the potential ramp, wherein the nucleic probe is a linear nucleic acid probe and/or the target nucleic acid comprises a label.
BARTLETT PHILIP NIGER [GB]; BROWN TOM [GB]; RICHARDSON JAMES ALISTAIR [GB]; MAHAJAN SUMEET [GB]
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