Formation of Nanostructured Particles of Poorly Water Soluble Drugs and Recovery By Mechanical Techniques
The present invention provides a composition and method of forming an amorphous drug-loaded particle by forming one or more amorphous drug-loaded nanoparticles comprising one or more active agents stabilized by one or more polymers, desolvating the one or more amorphous drug-loaded nanoparticles to form one or more flocculated amorphous drug-loaded nanoparticles, filtering the one or more flocculated amorphous drug-loaded nanoparticles and drying the one or more flocculated amorphous drug-loaded nanoparticles to form amorphous drug-loaded particles.
JOHNSTON KEITH P [US]; WILLIAMS ROBERT O [US]; MATTEUCCI MICHAL E [US]
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