Antibodies Specific for Misfolded Proteins and Methods for their Production

Methods are provided for producing an antibody specific for a target antigen, in particular, antibodies capable of binding to prion proteins. The methods include adding a target antigen stabilising agent to a sample containing a target antigen, allowing the stabilising agent to stabilise the target antigen, incubating the stabilised target antigen with a conventional antibody immobilised on a solid support to form a complex, wherein the immobilised antibody is specific for the target antigen, immunising a host with the complex, and isolating antibodies specific for the target antigen from the host. Also provided are antibodies produced by the methods together with their use in treatment and diagnosis of disease, e.g. prion diseases.

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Patents:
WO 2,010,015,834

Inventor(s): TAYEBI MOURAD [GB]

Type of Offer: Sale



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