Therapeutic Aryl-am I Do-aryl Compounds and their Use
The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-amido-aryl compounds of the following formula (for convenience, collectively referred to herein as "AAA compounds"), which, inter alia, are (selective) retinoic acid receptor a (RARa) agonists. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to (selectively) activate RARa, and in the treatment of diseases and conditions that are mediated by RARa, that are ameliorated by the activation of RARa, etc., including cognitive disorders, memory impairment, memory deficit, senile dementia, Alzheimer's disease, early stage Alzheimer's disease, intermediate stage Alzheimer's disease, late stage Alzheimer's disease, cognitive impairment, and mild cognitive impairment.
WO 2,011,027,106 [MORE INFO
CORCORAN JONATHAN PATRICK THOMAS [GB]; KALINDJIAN SARKIS BARRET [GB]; BORTHWICK ALAN DAVID [GB]; ADAMS DAVID REGINALD [GB]; BROW
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