Bisphosphonate Compounds for Chelating Radionuclides
Bisphosphonate compounds for chelating radionuclides are described which have separate bisphosphonate and metal chelating groups joined by a linker, so that the bisphosphonate groups are available to complex to hydroxyapatite in bone, while the metal chelating group binds to the radionuclide. This avoids problems in the prior art, where the bisphosphonate groups are used for both binding functions which compromises the bone-seeking activity of the bisphosphonate groups when they are used to chelate the radionuclide.
BLOWER PHILIP JOHN [GB]; TORRES MARTIN DE ROSALES RAFAEL [GB]
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