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Gambogic Amine, a Selective TrkA Agonist with Neuroprotective Activity

Small molecule agonists, partial agonists, and antagonists for the TrkA receptor are described. The compounds are gambogic amines, where the carboxylic acid group of gambogic acid (CO2H) has been replaced by an amine group (CH2NR1R2). In some embodiments, the compounds selectively bind to TrkA but n
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Eliciting Immune Responses Using Recombinant MVA Viruses Expressing HIV Env, Gag and Pol Anitgens

Methods for eliciting beneficial immune responses against HIV by administering to a subject a recombinant MVA virus expressing HIV env, gag, and pol antigens are described. The recombinant MVA is administered at least three times and, in certain embodiments, is administered to a patient that has not
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Tumor Imaging Compounds

The invention provides novel amino acid compounds of use in detecting and evaluating brain and body tumors. These compounds combine the advantageous properties of alpha-aminoisobutyric acid (AIB) analogs namely, their rapid uptake and prolonged retention in tumors with the properties of halogen sust
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Methods for the Treatment of a Traumatic Central Nervous System Injury

Methods of treating a subject with a traumatic central nervous system injury, more particularly, a traumatic brain injury, are provided. The methods comprise a therapy comprising a constant or a two-level dosing regime of progesterone. In one method, a subject in need thereof is administered at leas
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Drug Resistant Immunotherapy for Treatment of a Cancer

The present disclosure is generally related to methods for combining chemotherapy and immunotherapy for the treatment of a cancer. The methods also relate to generating a drug-resistant cytotoxic immune cell line and uses thereof in conjunction with cytotoxic drugs.
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Systems Biology Approach Predicts Immunogenicity of Vaccines

A major challenge in vaccinology is to prospectively determine vaccine efficacy. Disclosed herein are methods and compositions for identifying early expression "signatures" that predicted immune responses in humans vaccinated with a vaccine.
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Fragile X Mental Retardation Protein (FMRP), Compositions, and Methods Related Thereto

The invention relates to fragile X mental retardation protein (FMRP), compositions, and methods related thereto. In certain embodiments, the invention relates to treating a neurological disorder by administering a P13K antagonist to a subject in need thereof. In other embodiments, the invention rela
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Gene Chip Technology for Determining Memory Genes

The present invention relates to methods of identifying genes involved in memory formation. This is accomplished by performing a gene chip identification of those genes expressed during transcription-dependent memory formation but not during trancription-independent memory formation. A statistical a
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Method of manufacture of 1,3-dioxolane and 1,3-oxathiolane nucleosides

Processes for the preparation of 1,3-oxathiolane nucleosides are provided that include efficient methods for the preparation of the 1,3-oxathiolane ring and subsequent condensation of the 1,3-oxathiolane with a pyrimidine or purine base. Using the processes described herein, the compounds can be pro
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Use of multimodality nanostructures to detect target substances

Briefly described, embodiments of this disclosure include multimodality nanostructures, methods of forming the multimodality nanostructures, and methods of using the multimodality nanostructures.
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NMDA Receptor Antagonists for the Treatment of Neuropsychiatric Disorders.

Provided are pharmaceutical compositions and methods of treatment or prophylaxis of certain neuropsychiatric conditions, in particular mood disorders. The compounds are of the general Formula I-V as described herein.
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Human Anti-PD-1, PD-l1, and PD-l2 Antibodies and Uses Therefor

The present invention is based, in part, on the identification of novel human anti-PD-1, PD-L1, and PD-L2 antibodies. Accordingly, the invention relates to compositions and methods for diagnosing, prognosing, and treating conditions that would benefit from modulating PD-1, PD-L1, and/or PD-L2 activi
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Use of mTOR Inhibitors to Enhance T Cell Immune Responses

It is disclosed herein that treatment of a subject with an mTOR inhibitor enhances antigen-specific T cell immune responses. Thus, provided herein is a method of enhancing an antigen-specific T cell response in a subject by administering to the subject a therapeutically effective amount of an mTOR i
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Methods for the Treatment of Graft-versus-host Disease

Methods are disclosed for treating or preventing graft versus host disease in a subject. The methods include selecting a subject in need of treatment for graft versus host disease; and administering to the subject a therapeutically effective amount of a TLR5 agonist such as a flagellin polypeptide,
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Noscapine and Noscapine Analogs and their Use in Treating Infectious Diseases By Tubulin Binding Inhibition

Compositions and methods for treating or preventing infectious diseases, and inhibiting the ability of microbes to travel within mammalian cells, and inhibiting microbial replication, are disclosed. The compositions include various noscapine analogs, which are capable of blocking the movement of vir
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Microelectrode Stimulation for Treatment of Epilepsy Or Other Neurologic Disorder

Methods for treating a neurologic disorder by neurostimulation. The stimulation may be applied using electromagnetic energy. In certain embodiments, distributed electrical stimulation is applied to a target site of the brain in an ongoing fashion. A microelectrode array may be used to provide the di
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Treating Various Disorders with 7,8-dihydroxyflavone and Derivatives Thereof

Novel compounds and methods related to the activation of the TrkB receptor are provided. The methods include administering in vivo or in vitro a therapeutically effective amount of 7,8-dihydroxyflavone or derivative thereof. Specifically, methods and compounds for the treatment of disorders includin
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Treating Various Disorders Using TrkB Agonists

Novel compounds and methods for activating the TrkB receptor are provided. The methods include administering in vivo or in vitro a therapeutically effective amount of a compound containing four six-membered rings and a substituted or unsubstituted C5 or C6 heteroaryl or hetero-cycloalkyl ring and ph
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Inhibitors of Nox Enzymes and Methods of Use Thereof

Inhibitors of Nox enzymes, such as Noxl, Nox2, and Nox3, and methods of making and using such compounds are describe herein.
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Treatment of EBV and KHSV Infection and Associated Abnormal Cellular Proliferation

A method and composition for the treatment, prevention and/or prophylaxis of a host, and in particular, a human, infected with Epstein-Barr virus (EBV), is provided that includes administering an effective amount of a 5-substituted uracil nucleoside or its pharmaceutically acceptable salt or prodrug
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Triarylmethane Analogs and their Use in Treating Cancers

Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are triphenyl methane analogs. The compounds and compositions can be used to treat and/or prevent a wide variety of cancers, including drug resistant cancers, infla
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Use of Imipramine Blue and Analogs Thereof in Treating Cancers

Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are triphenyl methane analogs. The compounds and compositions can be used to treat and/or prevent a wide variety of cancers, including drug resistant cancers, infla
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NMDA Receptor Antagonists for Neuroprotection.

Provided are compounds, pharmaceutical compositions and methods of treatment or prophylaxis of disorders associated with NMDA receptor activity, including neuropathic pain, stroke, traumatic brain injury, epilepsy, and related neurologic events or neurodegeneration. Compounds are of the general Form
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PROCESSES FOR PREPARING 5,7 DIAMINOPYRAZOLO[1,5-a] PYRIMIDINE COMPOUNDS

Processes for the preparation of certain 5,7-diaminopyrazolo[1,5-a]pyrimidine compounds comprising the reaction of a primary or secondary amine and a protected 5-halo-7-aminopyrazolo[1,5-a]pyrimidine compound in solvent system comprising water and one or more organic solvents, optionally in the pres
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Prostate Cancer Biomarkers to Predict Recurrence and Metastatic Potential

Described herein are methods for predicting the recurrence, progression, and metastatic potential of a prostate cancer in a subject. For example, the method comprises detecting in a sample from a subject one or more biomarkers selected from the group consisting of FOXO1A, SOX9, CLNS1A, PTGDS, XPO1,
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Methods for the Treatment of Infections and Tumors

PD-I antagonists are disclosed that can be used to reduce the expression or activity of PD-I in a subject. An immune response specific to an infectious agent or to tumor cells can be enhanced using these PD-I antagonists in conjunction with an antigen from the infectious agent or tumor. Thus, subjec
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Composite Biomimetic Materials

In an embodiment, composite materials having a fiber of relatively high Young's modulus is embedded in an elastin mimetic material with a relatively low Young's modulus. In an embodiment, the fiber is crimped so as to provide a composite material having a non-linear stress-strain curve, with an init
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Heat Shock Protein 90 Inhibitors, Methods of Preparing Same, and Methods for their Use

Novel classes of molecular chaperone Heat shock protein 90 (Hsp90) inhibitors are disclosed. These compounds are useful in treating and preventing cancer and other Hsp90-related diseases and conditions, such as inflammation and neurodegenerative disorders. Methods of treating and preventing cancer a
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Aminoquinoline Derived Heat Shock Protein 90 Inhibitors, Methods of Preparing Same, and Methods for their Use

Novel classes of molecular chaperone Heat shock protein 90 (Hsp90) inhibitors and methods for making these classes are provided herein. These compounds are useful in treating and preventing cancer and other Hsp90-related diseases, such as inflammation and neurodegenerative disorders. Also provided h
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9-aminonoscapine and Its Use in Treating Cancers, Including Drug- Resistant Cancers

9-aminonoscapine, prodrugs thereof, and pharmaceutically acceptable salts thereof, are disclosed. Pharmaceutical compositions including 9-aminonoscapine, and methods of preparation and use thereof are disclosed. 9-aminonoscapine is a noscapine analog that can be used to treat and/or prevent a wide v
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Small-molecule Inhibitors of HIF and Angiogenesis

Inhibitors of Hypoxia Inducible Factor (HIF) and angiogenesis, for example 2,2-dimethylbenzopyran compounds and derivatives thereof, and methods of their use including treatment of cancer, disorders leading to ischemia (e.g., stroke and ischemic heart disease), and non-cancerous angiogenic diseases
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Compounds, Intermediates, and Methods of Preparing the Same

The present disclosure provides optionally substituted seven-membered ring isomers of naturally occurring carbohydrate compounds, methods of synthesizing these compounds, intermediate compounds, methods of synthesizing the intermediate compounds, and the like.
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Conjugates of Noscapine and Folic Acid and their Use in Treating Cancer

The present invention is directed to compounds which are conjugates of two non-toxic natural products, noscapine (and various noscapine analogs) and folic acid (and various folic acid analogs), where the folic acid is conjugated to noscapine or the noscapine analog at the 9-position on the isoquinol
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MVA Expressing Modified HIV Envelope, Gag, and Pol Gene

PROBLEM TO BE SOLVED: To control pathogenic immunodeficiency virus. ; SOLUTION: There is provided a pharmaceutical composition comprising a recombinant MVA virus expressing an HIV env, gag, and pol gene or modified gene thereof for production of an HIV Env, Gag, and Pol antigen by expression from th
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ENANTIOMERICALLY PURE beta -D-DIOXOLANE-NUCLEOSIDES

A method and composition for the treatment of humans infected with HIV that includes the administration of an HIV treatment amount of an enantiomerically pure (beta)-D-dioxolanyl purine nucleoside of formula (I), wherein R is OH, Cl, NH2, or H, or a pharmaceutically acceptable salt or derivative of
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Compositions, Materials Incorporating the Compositions, and Methods of Using the Compositions and Materials

The invention relates to composition and methods of using described compositions as oxidative catalysis. In certain embodiments, the invention relates to a composition having a nitrogen oxide species, bromide ion, a metal, and oxygen. In certain embodiments, the composition catalyzes sulfides.
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Compositions and Methods for Treatment Or Prevention of Post-operative Organ Or Tissue Inflammation

Compositions, methods and kits for treatment or prevention of post operative organ or tissue inflammation are provided. The compositions contain an effective amount for local delivery, of an anti-inflammatory agent, alone or in combination with other pharmacologic agents, embedded within a polymeric
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Methods of Determining Renal Function using Technetium-99m Tricarbonyl-nitrilotriacetic acid

This disclosure relates to the methods of imaging the kidneys and measuring renal function using the renal tracer 99mTc(CO)3(NTA) (technetium-99m tricarbonyl-nitrilotriacetic acid). The disclosure encompasses methods of imaging the kidneys and measuring effective renal plasma flow (ERPF) in an anima
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Elemental Iron Nanoparticles

Synthesis of iron nanoparticles with a substantially unoxidized iron core and a biocompatible coating is described. The nanoparticles are formed by reacting an iron salt solution with a reducing agent in a substantially oxygen-free environment and exposing the formed iron particles to a biocompatibl
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Methods of Preparing 1-deoxy-sphingoid Bases and Derivatives Thereof

Novel methods of synthesizing 1-deoxy-sphingoid bases and derivatives are disclosed. The synthesis is achieved from commercially available and inexpensive starting materials. The process includes thioesterification, cross-coupling, and reduction. The process may also include directed epoxidation, re
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Methods of Neuroprotection Using Neuroprotective Steroids and a Vitamin D

Described herein are compositions and methods for treating or preventing nervous system injury. In particular, the methods and compositions relate to the use of at least one neuroprotective steroid, such as progesterone, and vitamin D.
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Subunit Selective NMDA Receptor Potentiators for the Treatment of Neurological Conditions

Provided are compounds, pharmaceutical compositions and methods of treating or preventing disorders associated with NMDA receptor activity, including schizophrenia, Parkinson's disease, cognitive disorders, depression, neuropathic pain, stroke, traumatic brain injury, epilepsy, and related neurologi
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Display of Patient-specific Data

Systems, methods, and computer-program products identify clinical data corresponding to a plurality of patients located within a common health care delivery unit, and apply one or more rules to at least some of the clinical data using at least one quality and/or safety measure-specific specification
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Compounds, Compositions, Methods of Synthesis, and Methods of Treatment

Briefly described, embodiments of this disclosure include compounds as described herein, labeled compounds as described herein, pharmaceutical composition including compounds described herein, methods of imaging, method of forming a compound as described herein, and the like. In particular, embodime
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Purine Nucleoside Monophosphate Prodrugs for Treatment of Cancer and Viral Infections

The present invention is directed to compounds, compositions and methods for treating or preventing cancer and viral infections, in particular, HIV, HCV, Norovirus, Saporo virus, HSV-I, HSV-2, Dengue virus, Yellow fever, and HBV in human patients or other animal hosts. The compounds are certain 6-su
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Internet-based Cognitive Diagnostics Using Visual Paired Comparison Task

Disclosed are methods for diagnosing declarative memory loss using mouse tracking to follow the visual gaze of a subject taking a visual paired comparison test. Also disclosed are methods for diagnosing dementia such as mild cognitive impairment and Alzheimer's disease.
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Catecholamine Derivatives for Obesity and Neurological Disorders

Novel compounds, compositions, and methods related to the activation of the TrkB receptor are provided. The methods include administering in vivo or in vitro a therapeutically effective amount of a compound containing a catecholamine backbone and pharmaceutically acceptable salts, prodrugs, and deri
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Polyoxometalate Water Oxidation Catalysts and Methods of Use Thereof

Homogeneous water oxidation catalysts (WOCs) for the oxidation of water to produce hydrogen ions and oxygen, and methods of making and using thereof are described herein. In a preferred embodiment, the WOC is a polyoxometalate WOC which is hydrolytically stable, oxidatively stable, and thermally sta
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Potent Combinations of Zidovudine and Drugs That Select for the K65R Mutation in the Hiv Polymerase.

Combinations of antiretroviral nucleoside reverse transcriptase inhibitors, and methods for their use in treating retroviral infections, are provided. In one embodiment, the combinations include non-thymidine nucleoside antiretroviral agents, such as tenofovir-DF, abacavir, APD and DAPD, that select
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Methods and Systems for Screening for and Diagnosing Dna Methylation Associated with Autism Spectrum Disorders

Methods and systems for population screening and diagnostics are provided. In particular methods and systems for population screening of individuals for genetic disorders due to alterations in DNA methylation and for the diagnostic testing for such disorders are provided.
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Nanocarrier Therapy for Treating Invasive Tumors

Liposomes of a size of less than 200 nanometers target tumors and preferentially deliver imipramine blue to tumors, including brain tumors such as gliomas. The imipramine blue decreases the invasiveness of the tumors, and inhibits tumor metastasis. The liposomes include cholesterol and chemically pu
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Methods and Devices for Drug Delivery to Ocular Tissue Using Microneedle

Methods and devices are provided for targeted administration of a drug to a patient's eye. In one embodiment, the method includes inserting a hollow microneedle into the sclera of the eye at an insertion site and infusing a fluid drug formulation through the inserted microneedle and into the suprach
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Methods of Identifying Safe NMDA Receptor Antagonists.

Processes are providedfor the identifcation a compound that is useful to treat or prevent a disorder that lowers the pH in a region of affected tissue comprising assessing the difference in potency, or potency boost, of the compound at physiological pH versus disorder-induced pH in a cell that expre
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Use of Rankl to Induce Differentiation of Microfold Cells (M Cells)

The differentiation of microfold (M) cells is important in mucosal immunity. The differentiation of M cells is desirable, such as in situations in which a host response to an antigen is sub-optimal, or wherein increased uptake of a compound is desired. Methods are provided herein for increasing a mu
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Alzheimer's Disease Imaging Agents

This invention provides compounds and methods of imaging amyloid deposits using radiolabeled compounds. This invention also provides a method of inhibiting the aggregation of amyloid proteins to form amyloid plaques or deposits, a method of determining a therapeutic compound's ability to inhibit agg
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Methods and Compositions for Improved Delivery of Therapeutic and Diagnostic Agents

Among other things, this disclosure provides for compounds having a targeting moiety linked to a therapeutic moiety and/or a diagnostic moiety; the synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and, methods for treating or diagnosing disorders. Som
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Imaging Agents

This invention provides amino acid derivatives useful in detecting and evaluating brain and body tumors, including (1S,2S) anti-2-[18F]FACPC and (1R,2R) anti-2-[18F]FACPC.
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Targeting Therapeutic Agents

Provided are devices, systems, and methods for targeted administration of therapeutic agents to a subject. For example, provided are devices, systems, and methods for targeting the administration of peri-urethral bulking agents.
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Branched Multifunctional Nanoparticle Conjugates and their Use

Disclosed herein are compounds and compositions including a polyglycerol nanocarrier, a therapeutic agent or imaging agent, and optionally a targeting agent. In certain aspects the disclosed compounds include biocompatible hyperbranched polymer nanocarriers. Such compounds and compositions are usefu
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PH-dependent NMDA receptor antagonists

NMDA receptor blockers, including pH-sensitive NMDA receptor blockers, are provided as neurprotective drugs that are useful in stroke, traumatic brain injury, epilepsy, and other neurologic events that involve acidification of brain or spinal cord tissue. Compositions and methods of this invention a
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Heterocyclic Peptide Ketoamides

A novel class of peptide a-ketoamides useful for selectively inhibiting calpains, selectively inhibiting cysteine proteases, and generally inhibiting all cysteine proteases, having the formula M-AA2-AA1-CO-NH-(CH2)n-R3. Processes for the synthesis of peptidyl a-ketoamide derivatives. Compositions an
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Re-engineered UV Damage Endonuclease, Compositions and Methods

Provided are methods and compositions for reducing damage to skin by ultraviolet light and other agents that cause distortion to double stranded DNA and methods for reducing damage to other organs due to such DNA distortion. These compositions comprise a novel truncated UV damage endonuclease (a tru
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BHC80 - Histone Complexes and Uses Thereof

Provided herein is the tertiary structure of domains of the BHC80 protein, including the PHD finger domain, such as when the BHC80 protein is complexed with an unmodified histone H3 tail in the presence of zinc. The invention provides structural and functional information for use in the identificati
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Cyanine-containing Compounds for Cancer Imaging and Treatment

This invention relates generally to cyanine-containing compounds; pharmaceutical compositions comprising cyanine-containing compounds; and methods of using cyanine-containing compounds for cancer cell imaging, cancer cell growth inhibition, and detecting cancer cells, for example. Compounds of the i
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Methods for Determination of Protein Phosphatase Activity, and Uses in Predicting Therapeutic Outcomes

One aspect of the present disclosure encompasses methods for determining a protein kinase or phosphatase activity in a biological sample, comprising: contacting in a reaction mix a first test sample and a fluorescently-labeled peptide substrate capable of being modified by a protein phosphatase or a
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PREPARATION OF SYNTHETIC NUCLEOSIDES VIA p-ALLYL TRANSITION METAL COMPLEX FORMATION

This invention provides highly regioselective and stereoselective processes for preparing synthetic nucleosides. A process for the preparation of synthetic nucleosides is provided that comprises a) preparing a bicycloamide derivative, b) reacting the bicycloamide derivative with a nucleic acid base
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Methods of Making Monoclonal Antibodies Using Fusion-Peptide Epitope Adoptive Transfer (F-PEAT) Technology

Disclosed are compositions and methods for related to monoclonal antibodies specific for single amino acid variation in an antigen.
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Evaluating Magnetic Resonance Spectra

Provided are methods, systems and computer program products evaluating magnetic resonance (MR) signals from a sample. The methods and systems can be used to evaluate MR signals from various constituents (e.g., metabolites, macromolecules) of the sample.
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Modulation of Sodium Channels By Nicotinamide Adenine Dinucleotide

The present invention relates to the use of oxidized nicotinamide adenine dinucleotide (NAD+) or of its reduced form, NADH, as sodium channel modulators. The present invention also relates to the use of compositions containing NAD+ or NADH to treat conditions associated with sodium channel current,
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Systems and Methods for Preventing Mistransfusion

In some embodiments, a system and a method for preventing mistransfusion of a patient pertain to obtaining a sample of the patient's blood, obtaining a sample of blood that is about to be infused into the patient, mixing the samples together, determining whether the samples are compatible, and if th
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Compositions and methods for generating an immune response

We have developed DNA and viral vectors that can be used, alone or in combination, as a vaccine against one HIV clade, subtype, or recombinant form of HIV or against multiple HIV clades, subtypes, or recombinant forms. Moreover, the vectors can encode a variety of antigens, which may be obtained fro
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Immunogenic Compositions and Methods of Use Thereof

Embodiments of the disclosure encompass compositions and methods for generating immune responses in an animal or human host Embodiments of the compositions encompass proteins derived from the surface proteins of bacteria and protozoa, and in particular the flagellum component flagellin, and which ha
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Branched Diepoxide Compounds for the Treatment of Inflammatory Disorders

The present invention provides certain diepoxide carbocyclic compounds wherein at least one carbocyclic ring carbon includes two non-epoxide substituents, and pharmaceutical compositions containing the same, for the treatment or prophylaxis of inflammatory, autoimmune and hyper- or abnormally prolif
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2'-fluoronucleosides

The 2'-fluoronucleoside is provided to treat hepatitis type B, hepatitis type C, HIV(human immunodeficiency virus), and abnormal cell proliferation including tumor and cancer. The pharmaceutical composition for treating hepatitis type B in human comprises the 2'-fluoro-beta-D-nucleoside represented
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Predictive and Diagnostic Methods for Cancer

The present disclosure encompasses methods of diagnosing the presence of a cancer, and particularly a cancer of prostate or breast tissue, in a human subject, predicting the outcome or severity of the disease and methods of reversing the prostate cell transformation based on the presence or absence
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Vascular Access to Extra-vascular Space

Provided are methods for accessing tissue in the vicinity of a blood vessel. Also provided are devices for use in a lumen of a patient's organ and methods for shunting interior volumes of organs.
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Coated Quantum Dots and Methods of Making and Using Thereof

The present disclosure provides embodiments of a new class of hydroxylated quantum dots. The quantum dots have a hydroxylated coat disposed thereon, and which serves to minimize non-specific cellular binding and to maintain the small size of quantum dot probes. Embodiments of the coated quantum dots
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Steroid Analogues for Neuroprotection

Provided are steroid analogues functionalized with polar substituents at the C3 and/or C20 positions of the steroid ring system that exhibit improved water solubility. Also provided are pharmaceutical compositions comprising the steroid analogues and methods using the novel steroid analogues for the
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Reduced Dye Probes for the Detection of Radical Oxygen Species

Reduced dyes, such as hydrocyanines, deuterocyanines, and/or other deuterated dyes, such as deuteraled leuco dyes, capable of detecting one or more reactive oxygen species are described herein The reduced dyes are generally prepared by reducing the oxidized dye with a reducing agent, such as sodium
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Non-myelosuppressive Compounds, Pharmaceutical Compositions Thereof, and Methods of Treatment

The present invention provides microtubule targeting compounds that are myelo-sparing. Particularly, the MTCs of the invention are structurally designed to exhibit specificity for inhibiting ss-tubulin isotypes that are not related to the myelosuppression associated with other known MTCs. The invent
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Nucleoside Derivatives for Treatment of Caliciviridae Infections, Including Norovirus Infections

A method and composition for treating a host infected with a Caliciviridae virus, such as a Norovirus, comprising administering an effective treatment amount of a described modified nucleoside or a pharmaceutically acceptable salt thereof, is provided.
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Image-based Control Systems

Image-based control systems and methods automate the adjustment of medical devices. An image based-control system for an endoscope can include, in addition to the endoscope, a processing system and an actuator. The processing system can receive an image from an image capture device of the endoscope.
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Compositions and Methods for the Treatment of Infections and Tumors.

PD-1 antagonists are disclosed that can be used to reduce the expression or activity of PD-1 in a subject. An immune response specific to an infectious agent or to tumor cells can be enhanced using these PD- 1 antagonists in conjunction with an antigen from the infectious agent or tumor. Thus, subje
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Modified Factor VIII

Methods of treating patients with Factor VIII deficiency by administration of modified porcine factor VIII are disclosed. The particular modified porcine factor VIII is one in which most of the B domain has been removed through genetic engineering. This modified factor VIII is particularly useful fo
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Methods of Administering Porcine B-domainless FVIII

The present invention provides a method of administering porcine B-domainless factor VIII (OBI-1) to a patient having factor VIII deficiency to provide more rapid and effective protection against bleeding episodes, compared to formerly available methods, or to provide more effective protection to su
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Methods and Compositions for the Display of Polypeptides on the Pili of Gram-positive Bacteria

Provided herein are methods and compositions for the display of polypeptides of interest on the tip of pili of Gram-positive bacteria. According to the present invention, the polypeptide of interest is amino terminal to a Gram-positive bacterial pilus tip protein or an active variant or fragment the
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Haptics and Virtual Reality

Licensing of Software and/or Hardware technologies covering high performance collocated virtual reality and haptics, applicable to a number of fields.
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Upper Arm Wearable Exoskeleton

An exoskeleton having a first cuff adapted to be coupled to a user's lower limb is disclosed. The exoskeleton also includes a second cuff adapted to be coupled to the user's upper limb and a third cuff adapted to be coupled to the user's body. A first motor is mounted on the third cuff and has a fir
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Apparatus and Method for Preform Relaxation and Flow Control in Liquid Composite Molding Processes

A vacuum-induced injection molding apparatus is disclosed. The apparatus includes a tool surface having an injection port extending therethrough. A flexible film extends over and is sealingly coupled to the tool surface. The flexible film comprises an outer surface and an inner surface such that the
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Macromolecular Diffusion and Release from Self-assembled B-hairpin Peptide Hydrogels

A hydrogel for delayed release of an anionic macromolecule, wherein the hydrogel comprises the anionic macromolecule, 150 mM NaCl, and a peptide selected from the group consisting of SEQ ID NO:1 through SEQ ID NO:33 in an aqueous medium at a pH of 7.4; wherein the anionic macromolecule has an isoele
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Snap-off Blade Knife with Safety Stop

A snap-off blade knife having a handle including a proximal portion, a distal portion, and a handle axis extending between the proximal portion and the distal portion is disclosed. The knife also includes a blade slidingly disposed within the handle along the handle axis. The blade comprises a plura
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Multijunction High Efficiency Photovoltaic Device and Methods of Making the Same

Photovoltaic devices and methods of making photovoltaic devices are provided. The photovoltaic device comprises a plurality of solar cells electrically coupled to each other. The plurality of solar cells are formed of respective semiconductor material having different band gaps. Each solar cell incl
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Method for Maximum Power Point Tracking of Photovoltaic Cells By Power Converters and Power Combiners

This invention relates to a method for Maximum Power Point Tracking (MPPT) a photovoltaic cell by a power converter that provides an output current at voltages useful to operate electronics or charge batteries. This invention also relates to a method for Maximum Power Point Tracking (MPPT) multiple
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Systems and Methods for Obtaining an Image Alpha Matte

Methods and systems for obtaining an alpha matte for an image are disclosed. First and second known portions of an image are determined. The alpha matte for the image is estimated based on an initial fuzzy connectedness (FC) determination between the entire image and the first and second known porti
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Perlecan Fragments as Biomarkers of Bone Stromal Lysis

A method for the detection in a body fluid of perlecan polypeptide fragments that are biomarkers of tumor metastasis, and antibodies for detecting these fragments are described. An immunoassay kit for detecting the presence of these biomarkers in a body fluid, such as serum or urine, is also describ
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Nozzle-Based, Vapor-Phase, Plume Delivery Structure for Use in Production of Thin-Film Deposition Layer

A physical vapor deposition effusion method comprising translating a strip material through a physical vapor deposition zone in a deposition chamber and providing first and second substantially closed vessels located serially along the processing path in the same deposition chamber, each vessel emit
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Pan-Antagonists for the Androgen Receptor and Androgen Receptor Mutants Associated with Anti-Androgen Withdrawal

Disclosed herein are novel antagonists of the androgen receptor and androgen receptor mutations associated with clinical failure of currently prescribed anti-androgens and use of said antagonists in the treatment of conditions associated with inappropriate activation of the androgen receptor.
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High Lift Mower for Plastic Mulch

A high-lift mower is disclosed. The mower includes a frame, at least two wheels disposed along opposite sides of the frame and having a space between them, and a blade rotation mechanism, mounted to the frame, for providing a rotational force relative to the frame. A blade assembly is coupled to the
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Delivery System for Heparin-Binding Growth Factors

A device comprising a scaffold coated with a protein having at least 83% identity to the amino acid sequence of the core protein of domain I of a mammalian perlecan, wherein at least one glycosaminoglycan is attached to the protein is described. The device may be used in vitro or in vivo to induce r
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Fertility Enhancement Using Lipid Carriers and Bioactive Molecules

The invention relates to a composition and method for enhancing fertilization. Fertilization enhancement is achieved by effectively delivering bioactive molecules with a lipid anchor (GPI-linked proteins) to the surface of epididymal or ejaculated sperm. The process may be facilitated or promoted in
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