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Spinocerebellar Ataxia Type 8 and Methods of Detection
The present invention provides an isolated nucleic acid molecule containing a repeat region of an isolated spinocerebellar ataxia type 8 (SCA8) coding sequence, the coding sequence located within the long arm of chromosome 13, and the complement of the nucleic acid molecule. Diagnostic methods based
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Soft Switching Power Electronic Transformer
This patent document discloses power electronic transformers having a high-frequency link. An example apparatus include a transformer having a primary winding and a secondary winding, the transformer is configured to receive a primary power signal having a first frequency, a primary converter config
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Diagnostic Test Kits
This invention provides kits, devices, and methods for the detection of antibodies that recognize one or more proteins and/or antigens from porcine reproductive and respiratory syndrome virus (PRRSV). The antibodies may be in a biological fluid of a PRRSV infected or at risk subject. The invention m
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Replication of Patterned Thin-film Structures for Use in Plasmonics and Metamaterials
The present invention provides templating methods for replicating patterned metal films from a template substrate such as for use in plasmonic devices and metamaterials. Advantageously, the template substrate is reusable and can provide plural copies of the structure of the template substrate. Becau
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Neurotrophins and Uses Thereof
A neurotrophin polypeptide, and a biologically active fragment thereof, are described. Also, methods are disclosed that include providing a composition comprising the neurotrophin polypeptide to a subject, wherein the composition is effective to ameliorate at least one symptom or clinical sign of a
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Fluorescence Resonance Energy Transfer Assays for Sarco/endoplasmic Reticulum Calcium Atpase and Phospholamban
Provided herein are methods for identifying molecules capable of modulating SERCA, the SERCA-PLB complex or the microenvironment of the complex. An exemplary assay provided herein is fluorescence resonance energy transfer (FRET). Also provided herein are FRET assays that are optimized for high-throu
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Carbon Dioxide-based Geothermal Energy Generation Systems and Methods Related Thereto
Novel carbon dioxide-based geothermal energy generation systems, i.e., carbon plume geothermal (CPG) systems, and methods are provided. With the novel systems and methods described herein, geothermal energy can now be provided at lower temperatures and at locations other than hot, dry rock formation
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Classifying an Item to One of a Plurality of Groups
A method of classifying an item to one of a plurality of groups includes providing a plurality of predictors associated with the item. For each predictor, the item is assigned to one of the groups. An assignment number is determined for each group. The item is classified to one of the groups based o
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Transmit Opportunity Detection
The present application discusses, among other things, apparatus and methods for detecting and using a excess capacity on a wireless network medium. A method embodiment includes calculating a differential metric based on a first metric and a second metric for a primary network. The primary network c
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Decellularization and Recellularization of Organs and Tissues
The invention provides for methods and materials to decellularize an organ or portion thereof and to recellularize such a decellularized organ or portion thereof to thereby generate an organ or portion thereof.
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MP-SWIFT with Adiabatic Inversion Preparation
A magnetic resonance image is produced by means of the SWIFT technique with magnetization preparation using one or two adiabatic inversion pulses.
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Nucleotide Repeat Expansion-associated Polypeptides and Uses Thereof
Isolated polypeptides that are endogenously expressed from nucleotide repeat expansions are disclosed. In some cases, the polypeptides include polypeptide repeats. In some cases, the polypeptide repeats include at least five contiguous repeats of a single amino acid. In other cases, the repeats incl
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Sensing Tissue Properties
A sensor (100) for in-vivo tissue elasticity measurement is disclosed. The sensor utilises a micro-fabricated structure comprising multiple membranes (120a-c) with varying stiffness and is particularly designed for integration coupled to a medical instrument, such as a probe, an endoscopic tool, or
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Triptolide Prodrugs
The invention provides compounds of formula (I): or a salt thereof. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods using the
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Catheter Insertion Sterilization
A device includes a sheath having a lumen defined by a wall. The wall has an outer surface that is configured to emit ultraviolet light in a direction substantially normal to the wall. The lumen has a distal end configured for percutaneous placement. The lumen has a proximal end configured to receiv
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Methods of Treating HIV Patients with Anti-fibrotics
The invention relates to methods of treating patients infected with human immunodeficiency virus (HIV) with a therapeutic that has anti-fibrotic effects, for example, pirfenidone and analogs thereof.
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Homologous Recombination in Multipotent Adult Progenitor Cells
The invention relates to methods of altering gene expression by homologous recombination in a multipotent adult progenitor cell (MAPC). In particular, methods of producing a recombinant MAPC, of correcting a genetic defect in a mammal, of providing a functional and/or therapeutic protein to a mammal
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Spinal Probe with Tactile Force Feedback and Pedicle Breach Prediction
A spinal probe (10) comprises a handle (18), a shaft (20) coupled to the handle and a force sensor (14) to detect forces applied to a tip of the shaft. A controller that executes a predictive algorithm to predict whether or not the tip of the shaft is going to breach a cortex of a pedicle based on t
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Implantable Devices for Treatment of Sinusitis
Devices, methods and kits which, when installed or used, urge or maintain patency of sinus ostia, such as the ostium between a nasal passageway and a maxillary sinus, while maintaining some function of cilia extending within or near the ostium. In various examples, the devices comprise a first porti
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Treatment and Placement Device for Sinusitis Applications
Devices, methods and kits which, when installed or used, access, aspire, dilate, insufflate, drain or deliver fluid medicaments to, or place a patency device within a sinus area, such as a maxillary sinus or a maxillary sinus ostium. The device can include a hollow catheter and probe, and can be con
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Detection of Nucleic Acid Sequence Differences Using Coupled Ligase Detection and Polymerase Chain Reactions
The present invention relates to a method for identifying a target nucleotide sequence. This method involves forming a ligation product on a target nucleotide sequence in a ligase detection reaction mixture, amplifying the ligation product to form an amplified ligation product in a polymerase chain
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Analgesic Agents
he invention provides a compound of formula (I) or a salt thereof, as well as compositions comprising such compounds. The compounds and compositions are useful as analgesics.
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Exchange-assisted Spin Transfer Torque Switching
In general, the invention is directed to techniques for reducing the amount of switching current that is utilized within a magnetic storage (e.g., MRAM) device. An example apparatus includes a fixed magnetic layer that provides a fixed direction of magnetization, an exchange-coupled magnetic multi-l
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Anti-flavivirus Therapeutic
The present invention relates to anti-flavivirus compounds, including lycorine and derivatives thereof, and their use in treating a subject infected by a flavivirus. The present invention also relates to the use of the anti-flavivirus compounds for the prophylaxis of flavivirus infection. The presen
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Tissue and Object Retrieval Device and System
The invention described herein provides a device for tissue and/or object retrieval constructed for use with minimally invasive medical procedures. By virtue of its construction and operation, the device of the invention can obtain a relatively large amount of tissue (or object) while reducing or mi
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Improved Process for Preparing Bio-oils from Biomass
The invention described herein provides an improved process for preparing bio- oils from biomass using pyrolysis. The process can comprise a step of acid pre-treatment of biomass prior to microwave assisted pyrolysis, and comprise a reformation step prior to condensation. The process of the inventio
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Non-thermal Plasma Synthesis with Carbon Component
The disclosure herein describes a method for producing ammonia by introducing N2, CO and water into a non-thermal plasma in the presence of a catalyst, the catalyst being effective to promote the disassociation of N2, CO and water to form reactants that in turn react to produce NH3 and CH4. This dis
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DNA Cytosine Deaminase Inhibitors
Cytosine deaminase inhibitors and methods for identifying inhibitors of the anti-retroviral activity of APOBEC3G are described.
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Traffic Flow Monitoring for Intersections with Signal Controls
A method and system are provided for determining travel time through intersections by assigning an initial position for a virtual probe in the intersection and updating the position and velocity for the virtual probe such that the position and velocity of the virtual probe are determined multiple ti
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Selective Inhibitors of c-Jun N-terminal Kinases
Compositions and methods for treating, preventing, or ameliorating one or more symptoms, disorders, or conditions associated with particular c-Jun N-terminal kinase(s) (JNKs) activity are provided. Compositions contain small molecules such as pyrazoloanthrones.
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Improved Monitor of Heart Failure Using Bioimpedance
In a method of monitoring pulmonary edema in a human being, an electrical current is injected between a first electrode located in or around a heart and a housing of a medical device implanted in a chest region. A voltage potential is measured between a second electrode in a superior vena cava and a
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Ischemia/reperfusion Protection Compositions and Methods of Using.
The invention provides for ischemia/reperfusion protection compositions having one or more ketone bodies and melatonin. The invention also provides for methods of using such compositions to reduce or prevent ischemia/reperfusion injury due to blood loss, stroke or cardiopulmonary arrest or surgery.
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Coil Element Decoupling for MRI
An RF coil adjacent an imaging region includes a plurality of conducting coil elements, with each conducting coil element including a proximal portion and a distal portion. The RF coil also includes a capacitance between the distal portions of the at least two conducting coil elements. A mutual coup
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Road and Repair Materials Including Magnetite and Methods Regarding Same
A road and repair system and/or method using one or more components including a plurality of magnetite concentrate particles, at least one acidic activator including phosphate anions, and a plurality of reactive aggregate particles including iron.
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High Throughput Bioreactor
A continuous flow bioreactor system that includes a bioreactor, an optional post-bioreactor preparation chamber, a cell sorter, and an optional pre-bioreactor preparation chamber in a closed loop, useful for enriching a heterogeneous cell population growing in the bioreactor with an isolated subpopu
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Layered Zeolite Materials and Methods Related Thereto
A novel oxide material (MIN-I) comprising YO2; and X2O3, wherein Y is a tetravalent element and X is a trivalent element, wherein X/Y = O or Y/X = 30 to 100 is provided. Surprisingly, MIN-I can be reversibly deswollen. MIN-I can further be combined with a polymer to produce a nanocomposite, depolyme
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Guide Wire Engaging Ureteroscope
This document discusses, among other things, a ureteroscope having a notch or other structure at a distal end configured to engage a guide wire and facilitate cannulation.
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A Miniaturized, Dermal-adhesive-based Device for Position-independent, Non-invasive Fetal Monitoring
A system for fetal position-independent, non-invasive fetal monitoring includes a plurality of disposable adhesive patches for placement on an expectant mother's upper and lower abdomen. Each of the patches includes one or more miniature electronic devices embedded within the adhesive patches to det
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DNA Aptamers
The present invention relates to rapid diagnosis of Salmonella contamination using DNA aptamers.
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Catalytic Topoisomerase II Inhibitors
The invention provides methods and compositions useful for treating cancer, for selectively inhibiting topoisomerase II, and for inducing apoptosis.
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Block Copolymer Modified Vegetable Oil and Polymer Blends and Methods of Making Same
Embodiments of a polymer and vegetable oil based composition comprise a polylactide homopolymer, a vegetable oil dispersed inside the polylactide homopolymer, and a block copolymer configured to aid the dispersion of the vegetable oil inside the polylactide homopolymer.
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Analysis of Brain Patterns Using Temporal Measures
A set of brain data representing a time series of neurophysiologic activity acquired by spatially distributed sensors arranged to detect neural signaling of a brain (such as by the use of magnetoencephalography) is obtained. The set of brain data is processed to obtain a dynamic brain model based on
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Treating Cancer with Desthiazolyl Ritonavir
Treatment of cancer includes administering a compound of formula I, for example desthiazolyl ritonavir, to a subject. In particular, treatment of breast cancer is described.
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RF Coil for MRI which Can Be Switched Between Different Operational Modes
An RF coil system for magnetic resonance applications includes a multi-channel RF coil transceiver and a multi-channel RF coil. The RF coil system is structured for reconfiguration between a plurality of operational modes, e.g. from a quadrature coil mode to a phased array mode or from a single-reso
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High Mass Throughput Particle Generation Using Multiple Nozzle Spraying
Spraying apparatus and methods that employ multiple nozzle structures for producing multiple sprays of particles, e.g., nanoparticles, for various applications, e.g., pharmaceuticals, are provided. For example, an electrospray dispensing device may include a plurality of nozzle structures, wherein e
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Vision-aided inertial navigation
This document discloses, among other things, a system and method for implementing an algorithm to determine pose, velocity, acceleration or other navigation information using feature tracking data. The algorithm has computational complexity that is linear with the number of features tracked.
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Multipotent Adult Stem Cells and Methods for Isolation
The invention provides isolated stem cells of non-embryonic origin that can be maintained in culture in the undifferentiated state or differentiated to form cells of multiple tissue types. Also provided are methods of isolation and culture, as well as therapeutic uses for the isolated cells.
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Mri Contrast Using High Transverse Relaxation Rate Contrast Agent
This document discloses, among other things, a system and method of creating a positive contrast magnetic resonance imaging (MRI) feature using a high transverse relaxation rate contrast agent.
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Method and Apparatus for Mapping a Structure
A volume of a patient can be mapped with a system operable to identify a plurality of locations and save a plurality of locations of a mapping instrument. The mapping instrument can include one or more electrodes that can sense a voltage that can be correlated to a three dimensional location of the
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Preparation of Solvent-borne Polymeric Bioactive Coatings
Processes for preparation of a protein-polymer composite material are provided according to embodiments of the present invention which include providing an admixture of a polymer resin, a surfactant and a non-aqueous organic solvent. An aqueous solution containing bioactive proteins and substantiall
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Kidney Derived Stem Cells and Methods for their Isolation, Differentiation and Use
The invention relates generally to methods for isolation and culture of kidney stem cells, cells isolated by the methods, and therapeutic uses for those cells.
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Polylactide Composites and Methods of Producing the Same
Embodiments of polylactide composites comprise a polylactide, and a polymerized natural oil dispersed inside the polylactide.
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Detection Beyond the Standard Radiation Noise Limit Using Spectrally Selective Absorption
High sensitivity thermal detectors that perform beyond the blackbody radiation noise limit are described. Thermal detectors, as described herein, use spectrally selective materials that absorb strongly in the wavelength region of the desired signal but only weakly or not at all in the primary therma
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Bifunctional Lactide Monomer Derivative and Polymers and Materials Prepared Using the Same
The invention described herein provides a novel lactide monomer derivative and process for preparing the lactide monomer derivative. The monomer derivative of the invention is bifunctional in nature, and can be employed a variety of efficient synthesis processes to prepare various polymers. Further,
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Fastener Deployment System and Method
This document discloses, among other things, a long reach, side ejecting fastener placement apparatus suitable for use in nasal septal surgery. A first linear member carries a fastener body and a second linear member delivers a fastener retainer or provides support for placement of the fastener body
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For Natural muscle's movement behavior simulation device for e.g. robot arm, has mechanical energy source arranged parallel to damping member, where damping member regulates force delivered by device
The device has a mechanical energy source (2) and an elastic element e.g. mechanical tension spring (3), arranged in series. The mechanical energy source is arranged parallel to a damping member (6) e.g. magneto-rheological damper and hydro-pneumatic suspension system, that regulates force (5) deliv
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Optical diffraction arrangement for use in e.g. optical spectral apparatus, has mirror whose reflection plane is aligned parallel to and in symmetry plane of optical diffraction structure, where rays
The arrangement has a mirror (2) whose reflection plane is aligned parallel to and in a symmetry plane of an optical diffraction structure (1). Rays (4.1) that are incident in a defined area outside of an aperture are reflected on the diffraction structure, where the size of the diffraction structur
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Producing polyelectrolyte hydrogel bodies, useful e.g. as soft tissue implants, comprises filling a semi-permeable membrane-forming liquid and a coagulation medium in a hollow template to form hollow
Producing dimensionally stable polyelectrolyte hydrogel bodies (2) with defined three-dimensional shape, comprises: filling a semi-permeable membrane-forming liquid in a hollow template (1); separating a liquid film adhered on the template; filling a coagulation medium, preferably water or alcohol i
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Method for Precisely Determining the Fluorescence in a Layer System, Such As the Eye
The invention relates to a method for precisely determining the fluorescence in a layer system, such as the eye. The object of the invention is to provide a method that is as simple and requires as little effort as possible for evaluating the fluorescence in a layer system, by means of which the sum
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Ions accelerating method for e.g. ion beam- and tumor therapy, involves accelerating ions penetrating titanium foils, at high energy, and decelerating ions that are not penetrating titanium foils, at
The method involves time-correlated high intensive laser impulse irradiation of thin titanium foils (2) and electrical fields between the titanium foils and behind electrons (5) separated from the titanium foils. Ions provided in the electrical fields and penetrating the titanium foils, of ion beams
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Device and Method for Non-Contact Recording of Spatial Coordinates of a Surface
A device and a method for non-contact recording of spatial coordinates of a surface includes a sensor head and a controller connected to the sensor head. The sensor head is designed as a portable hand-held device, a projector and two cameras. The controller is also designed as a portable device, wit
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Biologically Active Molecules, Particularly Based on PNA and siRNA, Method for the Cell-specific Activation Thereof, and Application Kit to Be Administered
Biologically active molecules are inactivated for selective activation by target cells by being covalently bonded to one or more peptides each of which has one or more specific amino acid sequences that are selected in respect of enzymes cell-specific for target cells. The bonds, which are broken ex
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Transmission diffraction grating with antireflection coating has interrupted top layer for diffracting light, formed on two continuous uninterrupted layers on top of transparent substrate layer
The transmission diffraction grating has a transparent substrate layer (1). A non-diffracting antireflection coating has two continuous uninterrupted layers (2a,2b) formed on the top surface (1a) of the transparent substrate layer. An interrupted top layer (3) for diffracting light is formed on top
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Photosensitive Semiconductor Component
In a semiconductor device (1) with a photosensitive doped semiconductor layer (2), are released into the at absorption of electromagnetic radiation (6) electrical charge carriers, the photosensitive semiconductor layer (2) a structured interface (7).The structured interface (7) is at least one layer
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Hot-melt Adhesive and Method for the Manufacture Thereof
The invention relates to a hot-melt adhesive, comprising at least one polysaccharide ester (6) obtained through the reaction of a polysaccharide (5) with an imidazolide (3) in molten imidazole (1). The invention further relates to a method for manufacturing the hot-melt adhesive in which imidazole (
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Adaptive Mirror and Method for the Production Thereof
The invention relates to an adaptive mirror based on a ceramic substrate comprising a corresponding reflector and piezoelectric actuators, a cooling device being built into the substrate. The invention also relates a method for producing such a mirror. Said mirror can be used for the modulatation or
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Method and Device for the Production of a Grid with Chirp
The present invention relates to a method for the production of a grid with chirp, wherein a grid structure is inscribed in a carrier in that the carrier is exposed in a diffraction field of a diffraction grid (3), wherein the diffraction grid (3) is deformed into a state with a local and/or time-de
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Cell's bioactive protein production determining method, involves bonding catch antibody to beads, and analyzing spatial catch-antibody/protein/detection antibody-structures of beads for evaluating pro
The method involves bonding a catch antibody to beads e.g. Dynabeads(RTM: Superparamagnetic, monosized polymer particles). The beads are mixed with a suspension of cells in an analysis container. The beads are separated from the cell by action of a magnetic field, and brought in contact with a detec
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New fusion peptide comprising a coupling of a silencing domain with small molecule peptide aptamer, is androgen receptor inhibitor, useful to treat prostate cancer and benign prostatic hyperplasia
Fusion peptide (I) comprising a coupling of a silencing domain with small molecule peptide aptamer, for the inhibition of androgen receptor, is new. - ACTIVITY : Cytostatic. - MECHANISM OF ACTION : Androgen receptor inhibitor.
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Inhibitors of Phosphodiesterase Type 5A for Treating or Preventing Muscle Disease or the Symptoms Thereof in a Patient
Disclosed are pharmaceutical compositions and methods for treating or preventing muscle diseases or the symptoms thereof. The compositions typically include and the methods typically utilize phosphodiesterase type 5A inhibitors.
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Methods for Cloning Ferrets and Transgenic Ferret Models for Diseases
The invention provides a transgenic Mustelidae in which a gene associated with a human disease or condition comprises a targeted genetic modification, and uses thereof. Also provided is a method to cryopreserve Mustelidae embryos or cells, and to enhance the number of live offspring from cryopreserv
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Schweinfurthin Analogues
The invention provides fluorescent schweinfurthin analogs of formula(I) which are useful as probes and for the treatment of cancer and other diseases.
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Methods of Treating Pulmonary Diseases and Disorders by Modulating Calcium/Calmodulin Dependent Protein Kinase II Activity
Disclosed are methods of treating or preventing a pulmonary disease or disorder in a subject, the methods comprising administering an effective amount of an compound that inhibits Calmodulin Kinase II (CaMKII) activity, either directly or indirectly, thereby treating or preventing the pulmonary dise
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Vaccine, therapeutic composition and methods for treating or inhibiting francisella tularenis
The present invention is directed to compounds and methods for treating a mammal exposed to Francisella tularensis.
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Use of unmethylated CpG oligonucleotides for the treatment of allergy
An immuostimulatory nucleic acid containing an unmethylated CpG dinucleotide for use in a method of treating or preventing an allergy in a subject, wherein an effective dose of the immunostimulatory nucleic acid alone is to be administered to the subject.
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Immunomodulatory oligonucleotides
Oligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are initiated by unthylated CpG dinuc
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Rna Interference Suppresion of Neurodegenerative Diseases and Methods of Use Thereof
The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules.
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Methods of Improving Vaccine Immunogenicity
The present invention provides a process called "Immune Banking" that enhances vaccine efficacy by exploiting existing humoral responses. The process involves tagging new antigens with molecular markers recognized by an existing antibody response. This recognition of the tagged vaccine components en
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Cellulose Capsules and Methods for Making Them
Disclosed are cellulose capsules, methods for preparing a cellulose capsule, and compositions comprising cellulose capsules, including sustained- or controlled-release dosage forms comprising cellulose capsules.
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Immunostimulatory nucleic acid molecules
Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful a synthetic adjuvant.
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Combination Motif Immune Stimulatory Oligonucleotides with Improved Activity
A class of immunostimulatory nucleic acids having at least two functionally and structurally defined domains is provided. This class of combination motif immunostimulatory nucleic acids activates an immune response and is useful for treating a variety of immune realted disorders such as cancer, infe
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Diagnostics and Therapeutics for Glaucoma
The invention provides methods and compositions for diagnosing and treating glaucoma by detecting alterations in the Wnt signaling pathway-including changes in the level or bioactivity of frizzled related protein. The invention further provides methods for screening for anti-glaucomatous compounds b
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Method for Producing Layered Materials Using Long-lived Photo-induced Active Centers
The invention relates to a method for applying a photo-activated layered polymer coating to a substrate material in which one or more layers do not contain photoinitiator, or are not exposed to initiating light, but cure due to migration of cationic active centers. At least two separate monomer laye
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Treatment of Hepatitis C Virus Infections
This present invention provides for a new class of HCV NS3/4A protease inhibitors as additional therapeutics for hepatitis C virus. The proposed compounds, bilverdin, bilirubin, and derivatives thereof, are based on natural enzymatic products of heme metabolism that may be more stable, better tolera
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Long Acting Atrial Natriuretic Peptide (la-anp) and Methods for Use Thereof
Materials and methods related to making and using natriuretic polypeptides having a mutation that results in an extended carboxy terminus.
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Spray Dried Microbes and Methods of Preparation and Use
The invention provides spray-dried preparations of microbes and methods of using those microbes.
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Ankle Prosthesis Methods
Methods of implanting an ankle prosthesis in a subject having an ankle joint in need of replacement.
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Repeated Administration of Lentiviral Vectors to Respiratory Cells
The invention provides methods for administering lentiviral vectors to the respiratory system of a patient to treat a disease.
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Agr-mediated Inhibition and Dispersal of Biofilms
The present invention involves the use of activators of bacterial agr quoroum-sensing systems to block, inhibit or reverse biofilm formation. The biofilm may be located on an industrial or medical surface, or may be located in a subject, such as in a wound or infected organ, or on an in-dwelling med
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Method and Compositions for Treating and Preventing Seizures By Modulating Acid-sensing Ion Channel Activity
This invention provides novel methods and compositions for treating and preventing seizures by administration of ASIC1a receptor activating compounds. A novel method of assaying ASIC1a receptor activating compounds is included in the present invention. According to the invention applicants have demo
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Apparatus and Method for Carrying Out Multiple Reactions
The invention provides methods and an apparatus useful for site-isolating reagents or catalysts during chemical reactions. The methods and apparatus are useful for carrying out cascade or domino reactions.
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Diagnosis and Treatment of Age-Related Macular Degeneration
The invention relates to Factor H gene polymorphisms and haplotypes associated with an elevated or a reduced risk of AMD. The invention provides methods and reagents for diagnosis and treatment of AMD.
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Synthesis and Use of Nanocrystalline Zeolites
Embodiments of the present invention relate to a method for synthesizing nanocrystalline zeolites, the method comprising contacting starting products that comprise a solvent, a silicon source, a cation base, an organic template, and an aluminum source, or any combination thereof sufficient to produc
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Methods for the Preparation of Thiazolidinethione Indene-Based Chiral Auxiliaries
Methods for the preparation of indene-based thiazolidinethiones are provided comprising contacting 1-amino-2,3-dihydro-1H-inden-2-ol, or a substituted derivative thereof, with an acid under suitable reaction conditions to provide a first intermediate; and contacting the first intermediate with an al
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Modified Polydicyclopentadienes
The present invention provides novel, modified polydicyclopentadienes and methods to prepare modified polydicyclopentadienes. The modified polydicyclopentadienes prepared by the methods of the invention are useful in many applications including new and useful solid phases for chromatography.
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Hybrid Laser Ophthalmoscope
Provided is a hybrid laser ophthalmoscope comprising a laser light source, a LED light source, and a holographic diffuser, wherein the holographic diffuser is configured to shape a beam of light into a Maxwellian ring.
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Contact Tracking Using Wireless Badges
This application discusses apparatus and methods for tracking contacts between various entities in a region. An apparatus includes portable transceiver device having a radio, memory and a power supply. The portable transceiver device can detect and record a history of proximity to other transceiver
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2,4,6-trisubstituted Phenols Having Anesthetic Properties
Trisubstituted phenol compounds and methods of using the compounds, e.g., for anesthetizing a subject, are disclosed.
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Baculoviruses with Enhanced Virion Production and a Method for the Production of Baculoviruses
A method of co-expressing a portion of the VSV G protein gene or a truncated "stem" portion with GP64 and a retrovirus increases the titer of retroviral vectors. A truncated VSV G protein, preferably comprised of a small segment from the C-terminal portion of the ectodomain plus the transmembrane (T
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Methods and Devices for Arytenoid Repositioning
Methods and devices for repositioning the arytenoid cartilage of a human subject are disclosed.
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