PATENTS
For Sale or License
Notify me of New Entries
Receive an email whenever a new patent is added.
You can unsubscribe at any time.
Sparsely Cross-linked Nanogels: a Novel Polymer Structure for Microchannel DNA Sequencing
The present invention is generally directed to novel polymeric materials for use in the electrophoretic separation of nucleic acids. In particular, the novel polymer materials are sparsely crosslinked nanogels, dissolved in an aqueous buffer to form solutions with moderate to high viscosity. The pre
...
Polymer Nanofilm Coatings
Disclosed herein are nanofilm coatings for implantable medical devices comprising a diblock or triblock copolymer (PEO-PMMA or PMOXA-PDMS-PMOXA, respectively). Such nanofilms, may be used, for example, as amphiphilic supports for therapeutic agents. These materials are conducive towards the formatio
...
Multilayer structure with zirconium-oxide tunnel barriers and applications of same
A multilayer structure with zirconium-oxide tunnel barriers. In one embodiment, the multilayer structure includes a first niobium (Nb) layer, a second niobium (Nb) layer, and a plurality of zirconium-oxide tunnel barriers sandwiched between the first niobium (Nb) layer and the second niobium (Nb) la
...
Titanium dioxide, single-walled carbon nanotube composites
The present invention provides titanium dioxide/single-walled carbon nanotube composites (TiO2/SWCNTs), articles of manufacture, and methods of making and using such composites. In certain embodiments, the present invention provides membrane filters and ceramic articles that are coated with TiO2/SWC
...
Universal Phosphoramidite for Preparation of Modified Biomolecules and Surfaces
Reagents useful for attaching biomolecules (e.g., proteins, oligonucleotides, and other biomolecules) to a surface, processes of attaching molecules to a surface to form modified surfaces using these reagents, and methods of detecting a target compound using these modified surfaces are disclosed.
...
Compositions and Methods for Treatment, Research and Therapeutic Applications for Malaria
The present invention provides anti-Plasmodium immunogenic compositions comprising EVP1 (PFD0495c) or an antigenic portion thereof, as well as methods of immunizing against malaria employing these compositions. In other embodiments, the present invention provides methods of identifying Plasmodium in
...
Infrared-reflecting Films and Method for Making the Same
There is provided single layer infrared-reflecting films and a method of making the same that provide enhanced reflectivity in an 800 nanometer to 2500 nanometer infrared waveband. The method comprises providing a substrate, depositing onto the substrate a mixture of an oxide matrix material and eit
...
Energy Transfer Through Surface Plasmon Resonance Excitation on Multisegmented Nanowires
Disclosed herein is energy transfer on multisegmented nanowires via surface plasmon resonance excitation of visible light, such as solar energy, absorbed by metals sensitive to visible light and transferred to metals insensitive to visible light. The nanowires are prepared with controllable gap size
...
Substituted Phenyl Aziridine Precursor Analogs as Modulators of Steroid Receptor Activities
Disclosed are methods and pharmaceutical compositions for modulating one or more steroidal receptor activities. The methods typically utilize and the pharmaceutical compositions typically include one or more substituted phenyl aziridine precursors, their respective aziridines, analogs thereof, deriv
...
Self-assembly and Mineralization of Peptide-amphiphile Nanofibers
Peptide-amphiphilic compositions capable of self-assembly into useful nanostructures.
...
System and Methods for Dynamic Power Estimation for a Digital Circuit
A method for dynamic timing-dependent power estimation for a digital circuit having coupled interconnects and at least two gates. In one embodiment, the method includes the steps of capturing information on relative switching activities and timing dependence for the coupled interconnects in the digi
...
Methods and Compositions for Inhibiting Angiogenesis
The present invention relates to methods and compositions for modulating angiogenesis. In particular, the present invention relates to Pigment Epithelial-derived Factor (PEDF) fragments for use in modulating angiogenesis and treating angiogenesis mediated disease.
...
Coated Colloidal Materials
Coated colloidal materials, methods for making coated colloidal materials, and methods of using coated colloidal materials are disclosed. The method yields coated colloidal materials where the optical characteristics of the core is not adversely affected. The coated colloidal materials can be self-a
...
Universal Matrix
A method comprises: (i) providing a tip and a substrate surface, (ii) disposing a patterning composition at the end of the tip, (iii) depositing at least some of the patterning composition from the tip to the substrate surface to form a deposit disposed on the substrate surface, wherein the patterni
...
Transparent Nanowire Transistors and Methods for Fabricating Same
Disclosed are fully transparent nanowire transistors having high field-effect mobilities. The fully transparent nanowire transistors disclosed herein include one or more nanowires, a gate dielectric prepared from a transparent inorganic or organic material, and transparent source, drain, and gate co
...
Ceramic Composite Thin Films
A ceramic composite thin film or layer includes individual graphene oxide and/or electrically conductive graphene sheets dispersed in a ceramic (e.g. silica) matrix. The thin film or layer can be electrically conductive film or layer depending the amount of graphene sheets present. The composite fil
...
Substrate-independent Layer-by-layer Assembly Using Catechol-functionalized Polymers
The present invention provides a simple, non-destructive and versatile method that enables layer-by-layer (LbL) assembly to be performed on virtually any substrate. A novel catechol-functionalized polymer which adsorbs to virtually all surfaces and can serve as a platform for LbL assembly in a surfa
...
live muscle engine
The aim is to use living muscle tissues as transducers,they will convert glucose into motion or work.USE OF GLUCOSE AS RENEWABLE SOURCE OF ENERGY (THE LIVE MUSCLE ENGINE) The most efficient transducer is the living muscle it converts almost 50% of the glucose it gets from the blood into energy(moti
...
Methods and Systems for Magnetic Focusing of Therapeutic, Diagnostic or Prophylactic Agents to Deep Targets
Systems and methods are disclosed for trapping or focusing magnetizable particles comprising therapeutic agents at a distance using a dynamic magnetic field and feedback control, to enable the treatment of diseased areas deep inside a patient's body. The methods may be used to diagnose or treat dise
...
Sulfated Psyllium Derivative for Reducing the Risk of Chronic Human Diseases and Method for Preparing the Same
The invention is directed to a method for preparing sulfated psyllium derivatives for use to reduce the risk of chronic human diseases. The sulfation of psyllium was carried out with sulfur, trioxide, pyridine, dimethylformamide and chlorosulfonic acid in pyridine. Six total sulfated psyllium deriva
...
Active Microfluidic Membranes
The present invention relates to a biofabricated Active Microfluidic Membrane (AMM) in a microfluidic network of a microfluidic device and a method for the in situ biofabrication of such a microfluidic network. More specifically, the invention relates to devices exhibiting (and methods of) positioni
...
Identification of tumor-associated antigens for diagnosis and therapy
The invention relates to genetic products the expression of which is associated with cancer diseases. The invention also relates to the therapy and diagnosis of diseases in which the genetic products are expressed or aberrantly expressed, in particular cancer diseases.
...
Advanced Functional Biocompatible Foam Used As a Hemostatic Agent for Compressible and Non-compressible Acute Wounds
A sprayable polymeric foam hemostat for both compressible and non-compressible (intracavitary) acute wounds is disclosed. The foam comprises hydrophobically-modified polymers, such as hm-chitosan, or other amphiphilic polymers that anchor themselves within the membrane of cells in the vicinity of th
...
3-(indolyl)- or 3-(azaindolyl)-4-arylmaleimide derivatives for use in the treatment of colon and gastric adenocarcinoma
The present invention relates to the use of a compound of formula (I) wherein R 1 , and R 3 are as defined in the description and R 2 is a phenyl group which is substituted with 2 or 3 C 1 -G 6 alkoxy groups, or a physiologically acceptable salt thereof, or a solvate of the compound of formula (I) o
...
Carbohydrate Functionalized Catanionic Surfactant Vesicles for Drug Delivery
Carbohydrate functionalized catanionic vesicles that include a glycoconjugate and/or peptidoconjugate for vaccination or drug delivery, methods for forming these, and methods of using these.
...
Delivery of Transthyretin Across the Blood-brain Barrier As a Treatment for Alzheimer's Disease
The invention provides a composition comprising transthyretin and an ICAM-1 targeting agent, wherein the transthyretin and ICAM-1 targeting agent are coupled together, as well as methods of preparing such compositions. The invention further provides a diabody capable of binding specifically to ICAM-
...
System, Method, and Apparatus for Suction Gripping
A suction gripper includes a cup member, a suction port, and a valve. The cup member has inner and outer surfaces defining an opening such that the inner surface defines an inner cavity. The suction port provides suction. The valve in is fluid communication with the suction port and the inner cavity
...
Apparatus, Method, and Gel System for Analytical and Preparative Electrophoresis
The present invention relates to an electrophoresis apparatus comprising a gel chamber for receiving electrophoresis medium, a removable gel system, which is arranged in the gel chamber, having a separation gel for the electrophoretic separation of biological molecules such as nucleic acids or prote
...
Method and System for Determining Relative Displacement and Heading for Navigation
A system and method for determining a location of a mobile object is provided. The system determines the location of the mobile object by determining distances between a plurality of sensors provided on a first and second movable parts of the mobile object. A stride length, heading, and separation d
...
Novel Topology Selection and Broadcast Method for Rule-based Link State Routing
An apparatus and method are provided for optimizing the link-state information that is to be broadcast in a routing domain of a communication network for QoS rule-based link-state routing. The routers include any device capable of implementing the routing primitives. The apparatus and method involve
...
Antibodies Specific for Claudin 6 (CLDN6)
The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing Claudin-6 (CLDN6), including tumor-related diseases such as ovarian cancer, lung cancer, gastric cancer, breast cancer, hepatic cancer, pancreatic cancer, skin ca
...
Nanodevice Arrays for Electrical Energy Storage, Capture and Management and Method for their Formation
An apparatus, system, and method are provided for a vertical two-terminal nanotube device configured to capture and generate energy, to store electrical energy, and to integrate these functions with power management circuitry. The vertical nanotube device can include a column disposed in an anodic o
...
Controllable Miniature Mono-wing Aircraft
Micro/nano mono-wing aircraft with the wing configured as a winged seed (Samara) is uniquely suited for autonomous or remotely controlled operation in confined environments for surrounding images acquisition. The aircraft is capable of effective autorotation and steady hovering. The wing is flexibly
...
Method and Device for Producing a Radionuclide
In a method and a device for producing a radionuclide, an absorption column containing the radionuclide is eluted by means of an eluent in a first flow direction and subsequently in a second, opposite flow direction.
...
System and Method for Data Management in Large Data Networks
A system and method for storing an input data network, in the form of graph is provided. The system includes a master node and a plurality of slave nodes. The master node is operable to receive the data network in the form of a graph, the graph including a plurality of vertices connected by edges; c
...
Vaccine Composition Comprising 5'-cap Modified RNA
The present invention relates to modification of RNA with 5 '-cap analogs in order to improve the stability and increase the expression of said RNA, in particular in immature antigen presenting cells. The present invention provides a vaccine composition comprising said stabilized RNA, immature antig
...
Inhomogeneous compounds having high magnetic resistance, the production and use thereof
The invention relates to inorganic, intermetallic, inhomogeneous compounds having a magnetic resistance effect and an intrinsic field sensitivity of at least 7% at 1 T at room temperature. The invention further relates to a method for the production and use thereof; particularly as magnetic field se
...
Compound Composed of a Metal Ion and a Marker Precursor Having Two Or More Targeting Vectors, and Use of the Compound
Described is a compound of a metal or metal, such as radiopharmaceutical from a metallic radionuclide and a labeling precursor, which is constructed from a bifunctional macrocyclic chelating agent, a spacer, a linker and at least a targeting vector.
...
Use of 3-(indolyl)- Or 3-(azaindolyl)-4-arylmaleimide Derivatives in Leukenia Management
The present invention relates to the use of a compound of formula (I) wherein R1 is H, C1-C6-alkyl, phenyl-C1-C4-alkyl or phenyl, R2 is a phenyl group which is substituted with 2 or 3 C1-C6-alkoxy groups and R3 is indolyl or azaindolyl which may carry one or two substituents independently selected f
...
Monoclonal Antibodies for Treatment of Cancer
The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing GT468, including tumor-related diseases such as breast Cancer, lung Cancer, gastric Cancer, ovarian Cancer, hepatocellular Cancer, colon Cancer, pancreatic Cancer
...
Identification of Tumor-associated Markers for Diagnosis and Therapy
The invention relates to genetic products the expression of which is associated with cancer diseases. The invention also relates to the therapy and diagnosis of diseases in which the genetic products are expressed or aberrantly expressed, in particular cancer diseases.
...
Holding Device, Bite Element and System for Intraoral Radiography
The invention relates to a bite element, a holding device, a method, a computer program product and a system for creating and/or processing intraoral shadow images, in particular X-ray images. To this end, a holding device comprises a device base which is designed to define a determined or determina
...
Methods and Compositions for Diagnosis and Treatment of Cancer
The present invention relates to the identification of nucleic acid and amino acid sequences that are characteristic of tumor tissues such as ovarian tumor and lung tumor tissues and which represent targets for therapy or diagnosis of tumor diseases in a subject.
...
Methods and Compositions for Diagnosis and Treatment of Cancer
The invention relates to an isolated regulatory nucleic acid, comprising a nucleic acid sequence according to SEQ ID NO 2 or a biologically active fragment thereof that can be specifically amplified and detected by a polymerase chain reaction (PCR), to the use thereof as a tumor marker and for sampl
...
Use of Flt3 Ligand for Strengthening Immune Responses in Rna Immunization
The invention relates to supplying vaccine RNA to cells. The invention relates in particular to a common use of vaccine RNA and Flt3 ligand for inducing, creating or enhancing an immune response when administered to animals (including humans).
...
Radioactively Marked Cyclopropane Derivatives of DAT Affine Tropanes
The invention relates to radioactively marked cyclopropane derivatives of DAT affine tropanes suitable for the quantitative, non-invasive imaging of striatal and extrastiatal dopamine transporters (DAT) in humans and test animals by means of positron emission tomography (SPECT), autoradiography, or
...
Method for Producing Nanostructures Made of Metal Disulfides, Nanostructures Produced According to Said Method and Use Thereof
According to the invention, a metal M = Nb, Ti, Zr, Hf, Ta, V, Mo, W is inductively heated to a temperature in the range of between 1250 - 1400 DEG C in a single step process and is reacted with a gaseous sulphur compound. Said metal is maintained for 15 - 30 mins at a reaction temperature and is co
...
Methods Involving MS4A12 and Agents Targeting MS4A12 for Therapy, Diagnosis and Testing
The invention relates to methods involving MS4A12 and agents targeting MS4A12 which are useful for therapy, diagnosis and testing of disease states, in particular cancer diseases. In particular, the invention relates to agents which reduce or inhibit expression or activity of MS4A12, compositions co
...
Use of RNA for Reprogramming Somatic Cells
The present invention provides methods for de-differentiating somatic cells into stem-like cells without generating embryos or fetuses. More specifically,-the present invention provides methods for effecting the de-differentiation of somatic cells to cells having stem cell characteristics, in partic
...
Identification of Tumor-associated Markers for Diagnosis and Therapy
The invention relates to genetic products the expression of which is associated with cancer diseases. The invention also relates to the therapy and diagnosis of diseases in which the genetic products are expressed or aberrantly expressed, in particular cancer diseases.
...
Antioxidant and Paramagnetic Heparin-nitroxide Derivatives
The present invention relates to novel heparin-nitroxide derivatives comprising heparin and at least two and more nitroxides/polynitroxide radicals that are covalently coupled to heparin by derivatisation of glycosaminoglycan carboxyl or amino groups. The heparin-nitroxide derivatives are useful as
...
Monoclonal Antibodies Against Claudin-18 for Treatment of Cancer
The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLDl 8, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer,
...
Monoclonal Antibodies for Treatment of Cancer
The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing GT468, including tumor-related diseases such as breast cancer, lung cancer, gastric cancer, ovarian cancer, and hepatocellular cancer.
...
Method and Device for Isolating a Chemically and Radiochemically Cleaned 68Ga-radio Nuclide and for Marking a Marking Precursor with the 68Ga-radio Nuclide
The invention relates to initial Ge/Ga-generator elute which is guided directly to a cation exchanger, whereon Ga is quantitatively absorbed and is cleaned simultaneously in a chemical and radio chemical manner. Subsequently, the Ga-radio nuclide is combined with a radio pharmaceutical substance by
...
Method and System for Source Authentication in Group Communications
A method and system for authentication is provided. A central node for issuing certificates to a plurality of nodes associated with the central node in a network is also provided. The central node receives a first key from at least one node from among the plurality of nodes and generates a second ke
...
Automatic Parallelization Using Binary Rewriting
Binary rewriters that do not require relocation information and automatic parallelizers within binary rewriters are provided, as well as methods for performing binary rewriting and automatic parallelization. The method, in certain embodiments. includes disassembling a binary file and determining fun
...
Binary Rewriting Without Relocation Information
A binary rewriter that can provide complete code coverage without relocation information is provided, together with a method of performing such rewriting. The method can include processing a binary file as an original binary file. The method can also include disassembling the binary file to provide
...
Method and Apparatus for Authenticating Biometric Scanners
A method and apparatus for authenticating a biometric scanner involves estimating unique intrinsic characteristics of the scanner (scanner pattern), that are permanent over time, and can identify a scanner even among scanners of the same manufacturer and model. Image processing and analysis are used
...
Ultra-miniature Fiber-optic Pressure Sensor System and Method of Fabrication
Ultra-miniature surface-mountable Fabry-Perot pressure sensor is constructed on an optical fiber which utilizes a 45 DEG angled fiber tip covered with a reflective layer which steers the optical axis of the fiber by 90 DEG . The Fabry-Perot cavity is formed on the sidewall of the fiber and a polymer
...
Polymer Solid Electrolyte for Flexible Batteries
A flexible polymer solid electrolyte material useful in battery technology is described. The flexible solid electrolyte comprises a first block that has the ability to solvate alkali metal salts. The flexible solid electrolyte comprises a second block that has the ability to incorporate lithium ions
...
Processes for Plant Polysaccharide Conversion
The present invention provides a novel process for ethanol fermentation.
...
Engineered Proteases for Affinity Purification and Processing of Fusion Proteins
The present invention is directed to the identification of a protease prodomain that is capable of binding a corresponding protease with high affinity. The protease prodomain of the present invention is fused to a second protein to form a protease prodomain fusion protein. The presence of a protease
...
Process for the Preparation of Beta and Alpha Cryptoxanthin
The present invention relates to a process for converting lutein and/or lutein esters to (3R)-[beta]-cryptoxanthin and (3R,6'R)-[alpha]-cryptoxanthin, suitable for human consumption as dietary supplements, by employing safe and environmentally friendly reagents. (3R)-[beta]-Cryptoxanthin and (3R,6'R
...
Peptides for Transport of Therapeutics and their Carriers in Mouse Models and Humans
A system for targeted delivery of agents (e.g., molecular probes, diagnostic agents, therapeutic agents, imaging agents, research or analytical compounds, enzymes, peptides, proteins, lipids, lipoproteins, sugars, hormones, vitamins, nucleic acids, viruses, bacteria, and/or cells) including use of a
...
Devices, Systems and Methods for Magnetic-assisted Therapeutic Agent Delivery
Devices, systems and methods for magnetically assisted agent delivery are included. These devices, systems, and methods make use of a plurality of magnets or magnetic configuration.
...
Enhanced Cellulase Expression in S. Degradans
The invention provides organisms and methods of using and making organisms with enhanced cellulase expression.
...
Methods and Systems for Purifying Transferring And/or Manipulating Nucleic Acids
The disclosure provides methods, systems, and devices for purifying, transferring or manipulating nucleic acids while maintaining the 2D spatial relationship of the nucleic acids as they were present in the original sample having 2D spatial information.
...
Androgen Receptor Inactivation Contributes to Antitumor Efficacy of CYP17 Inhibitors in Prostate Cancer
Provided are methods of inhibiting CYP17 in a mammal, such as a human, that include administering an effective amount of at least one CYP17 inhibitor, such as VN/124-1, VN/125-1, VN/85-1, VN/87-1 and/or VN/108-1 to the mammal. Also provided are methods of down regulating androgen receptor (AR) prote
...
Multivalent Live Vector Vaccine Against Clostridium Difficile-associated Disease
The invention relates to a multivalent Clostridium difficile vaccine comprising a Salmonella Typhi live vector comprising the cell binding domain of TcdA toxin (CBD/A) of Clostridium difficile or an antigenic fragment thereof and the cell binding domain of TcdB toxin (CBD/B) of Clostridium difficile
...
Sur1 Inhibitors for Therapy
Methods and compositions are provided that are utilized for treatment and/or prevention of intraventricular hemorrhage or progressive hemorrhagic necrosis (PHN). In particular, the methods and compositions are inhibitors of a particular NCca-ATP channel and include, for example, inhibitors of SUR1 a
...
Protective Vaccine Against Staphylococcus Aureus Biofilms Comprising Cell Wall-associated Immunogens
Vaccine formulations effective against Staphylococcus aureus, including methicillin-resistant Staphylococcus aureus (MRSA) are disclosed, as well as methods of using the vaccine formulations in the treatment, prevention and prophylaxis of Staphylococcus aureus infections in a subject.
...
Derivatives of Apf and Methods of Use
Derivatives of bladder epithelial antiproliferative factor and methods of using them are disclosed. In specific embodiments, the glycopeptide compositions are useful for the treatment and/or prevention of medical conditions, including cancer. In other embodiments, there are compositions and methods
...
Predetermined Presentation of Patient Data At Bedside
Techniques for presenting patient data at the patient's bedside include receiving predetermined presentation style data that indicates a subset of fewer than all parameters available from an electronic medical records (EMR) system and a first arrangement on a display device of related parameters in
...
Aqueous sustained-release drug delivery system for highly water-soluble electrolytic drugs
The present invention relates to liquid sustained release suspension dosage forms comprising ionized forms of water-soluble drugs. In particular, the invention encompasses a liquid form controlled release drug composition comprising a dispersed phase comprising an ion-exchange matrix drug complex co
...
Method of Treating Organophosphorous Poisoning
The present invention is directed to various methods for treating organophosphorus poisoning in an animal that is at risk of exposure to an organophosphorus compound or preventing organophosphorus poisoning in an animal that has been exposed to an organophosphorus compound, by administering a therap
...
In Vivo Biofilm Infection Diagnosis and Treatment
The present invention relates to a method for in vivo detection of a biof?lm infection residing in a mammal, the method comprising (i) administering to the mammal a diagnostic-effective amount of a biofilm-specific probe, wherein the probe comprises a bio film-targeting moiety and a paramagnetic nan
...
Derivatives of APF and Methods of Use
Derivatives of a novel antiproliferative factor comprising a glycopeptide is disclosed. In specific embodiments, the novel antiproliferative factor is associated with the bladder. Compositions, diagnostic kits and reagents, and methods of using the compounds for identifying and/or treating interstit
...
Techniques for Determining the Effects on a System of a Component That Has Four States
Techniques for determining effects on a biological system include determining rate constants for a particular time interval starting at an initial time. Each rate constant indicates a rate of transition from one of four states to a different one of the four states for a component of a biological sys
...
Fluorescent Proteins and Uses Thereof
The present invention provides novel fluorescent proteins. In particular aspects of the invention, a novel fluorescent protein of the invention has an increase in quantum yield. In other particular aspects of the invention, a novel fluorescent protein of the invention has altered spectral properties
...
Non-hemolytic ClyA for Excretion of Proteins
The disclosure below provides a protein export system utilizing non-hemolytic variants of HlyE family member proteins for efficiently producing recombinant protein from a host cell. In a preferred embodiment, the protein export system utilizes protein export machinery endogenous to the host bacteriu
...
Novel Retinamide Retinoic Acid Metabolism Blocking Agents
Retinoic acid metabolism blocking agents (RAMBAs). The RAMBAs may be used for treatment of cancer, including breast and prostate cancers. Methods for preparing novel retinamide RAMBAs. The methods include reacting RAMBAs with terminal polar carboxylic acid group with a variety of amines in the prese
...
Composite Images for Medical Procedures
Medical imaging often involves the collective use of information presented in multiple images of an individual, such as images generated through different imaging modalities (X-ray, CT, PET, etc.) The use of a composite of these images may involve image registration to adjust for the variable positi
...
Response Gene to Complement 32 (RGC-32) in Disease
The invention relates to antibodies that bind to a fragment of the Response Gene to Complement-32 (RGC-32), as well as methods of using these antibodies. Particular methods of using the antibodies of the present invention include, but are not limited to, methods of detecting RGC-32 in a sample, meth
...
System and Method for Providing Optimal Concentrations for Medication Infusions
Techniques for medical infusions include determining a first infusion rate for administering a first medication to a patient. A fluid load is determined based at least in part on the first infusion rate. It is determined whether the fluid load exceeds a predetermined threshold based on a fluid maint
...
Antigen binding domains from fish
A process for the production of an antigen specific antigen binding domain using a transformed host containing an expressible DNA sequence encoding the antigen specific antigen binding domain, wherein the antigen specific antigen binding domain is derived from a variable region of the immunoglobulin
...
EGRF and PAR2 Regulation of Intestinal Permeability
The present invention provides a method of treating an autoimmune disease, comprising the steps of increasing transepithelial electrical resistance leading to decreased cell permeability. Further provided is ajnethod of treating celiac disease in an individual in need of such treatment, comprising t
...
Targeting Nad Biosynthesis in Bacterial Pathogens
The emergence of multidrug-resistant pathogens necessitates the search for new antibiotics acting on previously unexplored targets. Nicotinate mononucleotide adenylyltransferase of the NadD family, an essential enzyme of NAD biosynthesis in most bacteria, was selected as a target for structure-based
...
Electrosurgical Element and Uterine Mainpulator for Total Laparoscopic Hysterectomy
A vaginal cervical retractor used to maneuver and visualize the uterus during various medical examinations and procedures would include an inner tube provided with a movable assembly of plastic cups (cervical cup and vaginal cup) designed to be inserted into the uterine cavity and a retractable elec
...
MAGE-A3/HPV 16 Peptide Vaccines for Head and Neck Cancer
The present invention relates to Trojan antigens, and immunogenic compositions comprising the Trojan antigens. The present invention also relates to methods of generating an immune response in a subject using the Trojan antigens or immunogenic compositions. The present invention further relates to m
...
Co-signaling Methods for Treating Cancers
Provided herein is a method of treating a neoplastic disease in an individual in need of such treatment, comprising the steps of: expanding ?d T lymphocytes in vitro; priming Natural Kill cells in vitro; and administering said expanded ?d T lymphocytes and said primed Natural Kill cells to said indi
...
Methods for Treating Central Pain Syndrome and Other Pain Related Pathologies
Central pain syndrome (CPS) is a debilitating condition that affects a large number of patients with a primary lesion or dysfunction in the central nervous system. Despite its discovery over a century ago, the pathophysiology underlying the development and maintenance of CPS is poorly understood. Th
...
Attenuated Salmonella Enterica Serovar Paratyphi a and Uses Thereof
The present invention is drawn to a live, attenuated S. Paratyphi A strain, a live, attenuated S. Paratyphi A strain comprising a stabilized plasmid expression system, an S. Paratyphi conjugate vaccine, and methods of using these strains and conjugate vaccine.
...
Snap-on Two-piece Emergence Profile Healing Abutment
A snap-on two-piece emergence profile healing abutment provides a trans-gingival piece that can create various gingival shapes and contours of the dental implant emergence profile. The device consists of two main components: a central piece similar to standard healing abutments, having multiple face
...
Engineered Type IV Pilin of Clostridium Difficile
The present invention relates to engineered Clostridium difficile type IV pilin (tfp) genes, type IV pilin proteins which can serve as a diagnostic marker for identification of patients infected with C. difficile, and vaccines comprising type IV pilin proteins, antigenic fragments and variants there
...
Methods of Treating a Diabetic Embryopathy
Maternal diabetes can lead to a developmental malformation of an embryo. A developmental malformation caused by maternal diabetes is commonly referred to as a diabetic embryopathy. There is currently no effective treatment for reducing or inhibiting a diabetic embryopathy. To this end, the present i
...
Docosahexaenoic Acid for the Treatment of Heart Failure
There is currently no completely effective treatment for heart failure. Considering the need for, and current void in the medical field for, a treatment for heart failure, the invention is drawn to treating heart failure. In particular aspects, the invention is drawn to the discovery that certain po
...
Methods for Treating Cancers and Diseases Associated with 4-1BB (CD137) Expression
The present invention relates to the role of 4-1BB (CD137) ligand and anti-4-1BB (CD137) antibody in the treatment of cancers and diseases associated with 4-1BB (CD137) expression. More particularly, the present invention relates to the use of (i) 4-1BB (CD137) ligand for inducing proliferation and
...
Fracture-specific Distal Radius Plates
The invention provides an improved distal radius locking plate having a body comprising a shaft portion and a head portion. The shaft portion is adapted for receiving bone screws to fix the bone plate to a shaft of the radius. The head portion includes a first head section and a second head section.
...
Proximal Radius Locking Plate
The invention provides a proximal radius locking plate having a body comprising an elongate shaft portion and a head portion. The plate may have a gentle S-shape and a proximal twist. The shaft portion is adapted for receiving bone screws to fix the bone plate to a shaft of the radius. The head port
...
Apparatus and Method for Automating an Enema with Controlled Distension
An apparatus and method are provided for use in administering a rectal contrast enema to a patient to prepare the patient for a medical procedure. A rectal catheter may be provided to facilitate administration of the enema preparation to the patient. The rectal catheter may include a retention ballo
...
Page: 1 - <100 - <10 - 105 106 107 108 109 110 111 - 118 Next»