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DNA Biochip and methods of use
The subject invention concerns materials and methods for detecting nucleic acid sequences. One aspect of the invention concerns a silicon-based "biochip" comprising nucleic acid immobilized thereon. In one embodiment, the silicon comprises microcavities. The nucleic acid to be assayed for the presen
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Fish-ribosyn for antibiotic susceptibility testing
The subject invention concerns materials and methods for evaluating the susceptibility of bacterial cells to an antibiotic or other antimicrobial compound or agent. In one embodiment, a sample comprising a microbial population is exposed to an antibiotic of interest. The sample is then processed usi
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Lysophospholipids as Biomarkers of Ovarian Cancer
A method of using a bioactive lysophospholipid (LL) as a biomarker for detecting the presence and recurrence of ovarian cancer. Subspecies of LL, such as lysophosphatidic acid (LPA), lysophosphatidylinositol (LPI), lysophosphatidylcholine (LPC), and lysosphingolipid sphinsosine-1-phosphate (S1P), ar
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Cervical Plate System
An anti-subsidence, anti-translocation, fusion compression cervical plate system with interface visualization, drill guide and temporary pin is provided. In one embodiment the invention provides a vertebral plate for minimizing the ability of an inter-body cage, filled with bone (or BMP-soaked spong
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Predictive Value of Nuclear Excision Repair Genes for Cancer Survival
Patients who have their cancer surgically removed are at risk for recurrence, even though currently free of disease. Lung cancer patients with higher activity of a nuclear excision repair gene called ERCC1 were at a lower risk for recurrence than patients with lower activity of ERCC1. Hence, it is p
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Methods of Treating Cognitive Impairment
The subject invention concerns materials and methods for treating a person or animal having cognitive impairment. In one embodiment, the method comprises administering an effective amount of one or more inflammatory mediator(s), for example, fms-related tyrosine kinase 3 (Flt3) ligand, interleukin-6
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Materials and Methods for Capture of Pathogens and Removal of Aurintricarboxylic Acid from a Sample
The present invention concerns methods and materials for extracting infectious pathogens from a sample, such as blood, comprising the steps of creating a fibrin aggregate confining the pathogens and introducing a fibrin lysis reagent to expose the pathogens for analysis. The fibrin lysis reagent is
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Drug Delivery Device for Ovarian Cancer
A drug delivery device has been designed to directly deliver an agent to the ovaries through direct contact with the fallopian tubes. The device consists of three main components: a tubular inserter, a cylindrical chamber and a plunger. The device is a single-use applicator designed in a shape simil
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Method of performing in situ calibrated potentiometric pH measurements
A device for the precise and accurate potentiometric pH measurements in situ. Embodiments of a potentiometric device according to the invention consist of one or more glass pH-sensitive electrodes connected to a potentiometer. A key feature of the device is that, rather than being calibrated convent
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Metal Porphyrin Catalyzed Olefin Aziridination with Sulfonyl Azides
Cobalt(II) complex of P1 [Co(P1)], a new porphyrin that was designed on the basis of potential hydrogen bonding interactions in the metal-nitrene intermediate, is a highly active catalyst for olefin aziridination with azides. The [Co(P1)]-based system can be effectively employed for different combin
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Method of Modifying the Frequency Response of a Wooden Article
Disclosed is a method for modifying the frequency response of a wooden article by exciting the article with acoustic energy. Frequency response is the measure of a system's spectrum response at the output due to a signal of varying frequency (but constant amplitude) at its input. The acoustic energy
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Electrochemical Power Source using Halogenated Organic Compounds
Halogenated organic compounds that are inexpensive and are readily available have been used to present the examples of the invention. These chemicals, when in contact with water experience a reaction that releases oxy-halogenated acid. These compounds are weak acids and release hydrogen ions accordi
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Adaptive Location Data Buffering for Location-aware Applications
A method of buffering location data on a mobile device. The method transmits location data packets via an unreliable protocol to a receiving device and buffers a copy of the location data packet. Periodically, the method also transmits a location data packet via a reliable protocol to the receiving
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Architecture and Two-layered Protocol for Real-time Location-aware Applications
A two-layer communication protocol that supports efficient real-time location-aware application on multiple mobile devices that must communicate with each other and/ or a centralized server. The two-layer protocol includes a method of communicating data between a first mobile device and a second mob
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Transparent Contacts Organic Solar Panel By Spray
A method of fabricating organic solar panels with transparent contacts. The method uses a layer-by-layer spray technique to create the anode layer. The method includes placing the substrate on a flat magnet, aligning a magnetic shadow mask over the substrate, applying photoresist to the substrate us
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Method of Controlled Delivery for use of Electrochemical Power Source
A system and method for improving electrochemical power sources through the dispensing encapsulation and dispersion into galvanic chambers of an electrochemical cell. Features of the method include the optimization of the concentration levels of chemicals involved in desired energy producing reactio
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Methodology and apparatus for reduction of soft errors in logic circuits
The present invention includes a circuit-level system and method for preventing the propagation of soft errors in logic cells. A radiation jammer circuit in accordance with the present invention, including an RC differentiator and a depletion mode MOS circuit, when inserted at the output of a logic
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Endoscopic Overtube
An over-tube was developed for receiving and guiding endoscopic instruments into a patient's anus, through the colon, and into the peritoneum. The over-tube has a flexible sheath adapted for insertion into the anus through the colon and out the peritoneum of a patient. A stiffened region is used to
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Methods for Inhibiting Tumor Cell Proliferation
The subject invention concerns methods for inhibition of STAT biological functions using platinum complexes.
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Platinum Complexes and Methods of Use
The subject invention concerns platinum complexes that exhibit antitumor cell and/or antiparasitic activity. The subject invention also concerns the use of platinum complexes of the invention to treat oncological and inflammatory disorders. The platinum complexes of the invention can also be used to
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Control of Harmful Algal Blooms By Induction of Programmed Cell Death
The subject invention pertains to compositions, apparatus, and methods for controlling harmful algae and harmful algal bloom (HAB) based on the induction of the programmed cell death (PCD; apoptosis) pathway in the harmful algae, and to kits for determining algal susceptibility to PCD induction.
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Multichannel Trocar
A multi-channel trocar developed for use in 'minimal-access surgery/single incision laparoscopic surgery. The trocar permits surgical access of two or more articulating laparoscopic instruments or scopes through one skin incision using a dividing membrane to separate the working channels. This allow
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SHIP-Deficiency to Increase Megakaryocyte Progenitor Production
The invention concerns a method for increasing megakaryocyte and megakaryocyte progenitor numbers in vitro or in vivo by suppressing SH2-containing inositol-5-phosphatase (SHIP) function in megakaryocytes or megakaryocyte progenitors expressing the SHIP gene. SHIP function can be suppressed by admin
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Antiviral Activity of Cyclopentene Nitro-ester and Derivatives
Disclosed is a method of synthesizing new optically pure heterocyclic compounds using Pd(0) catalyzed intramolecular cyclizations. Analogs of cyclopentanes, like isoxazoline-2-oxide and furan, with similar framework to the cyclopentanes act as anti-HIV and anticancer agents which opens a whole new f
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Pharmaceutical Co-Crystal Compositions
A pharmaceutical composition comprising a co-crystal of an API and a co-crystal former; wherein the API has at least one functional group selected from ether, thioether, alcohol, thiol, aldehyde, ketone, thioketone, nitrate ester, phosphate ester, thiophosphate ester, ester, thioester, sulfate ester
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Trans-endoscopic Hydraulic Balloon Apparatus
A trans-endoscopic hydraulic balloon dilation apparatus includes a fluid reservoir containing a hydraulic fluid. A shaft has a lumen in fluid communication with a leading end of the fluid reservoir. A balloon is mounted on the shaft and an opening in the shaft enables hydraulic fluid to flow through
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Synergistic Modulation of Microglial Activation by Nicotine and THC
Treatment of microglial cells with nicotine and THC synergistically attenuate the microglial activation. Using microglial activation, the combination of THC and nicotine interact synergistically reduced LPS induced TNF-[alpha] release, showing that the combination of THC and nicotine clinically have
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Method of Predicting Chemotherapeutic Responsiveness of Cancer
Disclosed is a method of predicting clinical tumor outcome by providing gene expression from a tumor sample. The method utilizes a novel genetic screen to identify genes that contribute to chemotherapeutic responsiveness, using formalin fixed paraffin embedded clinical samples of epithelial cancer,
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Polyacrylate Nanoparticle Drug Delivery
Drug delivery of resistance reversal agents by polyacrylate nanoparticles for treatment of drug (e.g. chloroquine) resistant malaria. Also provided are drug delivery by polyacrylate nanoparticles of ciprofloxacin for treatment of anthrax.
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Antibacterial S-heterosubstituted Disulfides
Synthetically-derived S,S-heterodisubstituted disulfides that exhibit potent in vitro antibacterial activity against a variety of bacteria, including Staphylococcus aureus, methicillin-resistant Staphylococcus aureus and Francisella tularensis. The present invention provides compounds, methods and c
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Leukemia Treatment Method and Composition
A method of inducing high anti-leukemia activity responsive to the combination of hydroxamic acid analogue histone deacetylase inhibitors and PKC412 against human acute leukemia characterized as expressing phosphorylated (p)FLT3 kinase by a novel flow cytometry-based assay.
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Method of Electrogenically Controlling Pump Molecules
Activation of electrogenic pump molecules can be realized by a dynamic entrainment procedure which includes two steps: synchronization of individual pump molecules to work at the same pumping pace, and gradual modulation of the synchronization frequency. Na/K pump molecules were used as an example i
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Inhibition of SHIP to Enhance Stem Cell Harvest and Transplantation
The instant invention teaches the inhibition of SHIP expression, or function for the increased efficacy of autologous stem cell transplants. In another embodiment, interference with SHIP function can be used to temporarily expand and mobilize the hematopoietic stem cell compartment to assist with le
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Materials and Methods for Prevention and Treatment of RNA Viral Diseases
The subject invention concerns a method of inhibiting an RNA virus infection within a patient by increasing the amount of 2-5 oligoadenylate synthetase (2-5 AS) activity within the patient. Preferably, the preventative and therapeutic methods of the present invention involve administering a nucleoti
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Compositions Comprising Anti-icam-1 Antibodies
There is provided a method of preventing a respiratory infection by administering an effective amount of an agent for regulating ICAM-1 expression. Also provided is a composition for the prevention of respiratory infection including an agent which regulates ICAM expression. method of preventing RSV
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Seven Gene Breast Cancer Predictor
The invention provides a molecular marker set that can be used for prognosis of breast cancer in a patient using histologically normal tissue. The invention also provides methods for evaluating prognosis of breast cancer in a patient based on a molecular molecular signature.
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Method of Rapidly Visualizing Essential Neural Pathways
A method of optimizing pre-operative procedures in the field of neurosurgery. The method facilitates the identification of essential fiber tract pathways that must be avoided when planning and performing an operation, thereby increasing surgical safety and avoiding complications. The method includes
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Apparatus for Osteotomy and Graft Preparation
Surgical tools that increase surgical accuracy for orthopedic procedures involving long bone osteotomy with or without supplementation with allograft or autograft. Two clamps on the operative side are rigidly interconnected to one another with an adjustable rod that is locked into place, preserving
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CT Atlas of Musculoskeletal Anatomy to Guide Treatment of Sarcoma
The method includes the steps of obtaining atlas data in an atlas coordinate set from a computer-readable atlas of musculoskeletal structure. The atlas contains a data set representing a 3D model of musculoskeletal structure divided into the relevant musculoskeletal anatomic terminology. The method
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Dendroaspis Natriuretic Peptide for Treatment of Cancer
Disclosed is a method of inhibiting the growth of a cancer cell using Dendroaspis natriuretic peptide (DNP), isolated from the Green Mamba snake venom with similar structure to ANP, with or without four cardiac natriuretic peptides i.e., atrial natriuretic peptide (ANP), vessel dilator, long acting
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Cancer Treatment Using Natriuretic Peptides
The present invention includes a method of utilizing four peptide hormones to inhibit the growth of cancer(s). A dramatic decrease in the number of human pancreatic adenocarcinoma cells (i.e., the type of cancer with the highest mortality, with patients only surviving four months) was observed respo
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Electronic Mailbox System
An electronic mailbox system features: a mailbox housing with an inner cavity and slot for holding mail, a lid, an electrically-operable lock system for the lid, a mail sensor for detecting the mail being inserted into the slot, a first transmitter, a first receiver and a mailbox microprocessor; and
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Combination of Insulin and Ascorbate to Enhance Wound Healing
Provided is a method of stimulating collagen synthesis and proteoglycan (lumican and keratocan) accumulation. Collagenase isolated keratocytes were cultured with or without insulin with or without ascorbate. Insulin stimulates the synthesis of collagen but does not affect the accumulation of lumican
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Sphingosine 1-Phosphate Receptor Gene, SPPR
A novel sphingosine 1-phosphate receptor gene, herein termed sppr, and its splice variants. Sppr is up-regulated in LGL and is useful, for example, in the diagnosis and treatment of certain lymphoproliferative, neurodegenerative and autoimmune diseases.
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Novel Polymorph of Acetylsalicylic Acid, and Methods of Making and Using the Same
A polymorph of aspirin is provided by the present invention. Methods of making and using the same are also provided.
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Indoline Scaffold Shp-2 Inhibitors and Method of Treating Cancer
Protein tyrosine phosphatase (PTP) Shp2 is a non-receptor PTP that involved in cell signaling and regulation of cell proliferation, differentiation, and migration. Shp2 mediates activation of kinases that are involved in the pathogenesis of human carcinoma. A high throughput screen identified compou
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Individualized Cancer Treatments
The invention provides for compositions and methods for predicting an individual's responsitivity to cancer treatments and methods of treating cancer. In certain embodiments, the invention provides compositions and methods for predicting an individual's responsitivity to chemotherapeutics, including
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Method of Detecting Oncogenesis of Hematopoietic Cells
Disclosed in a method of detecting cancer using IL-27 receptors. IL27R is a cytokine receptor identified as a novel oncogene from an acute myeloid leukemia patient. It induces cancer-like properties when expressed in cells and can activate a protein that causes various myeloid cell disorders. The da
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Method for Early Detection of Cancers
The invention includes methods for detecting the presence of a neoplastic condition by comparing a sample level of a BIF-1 to a reference, wherein a low level of BIF-1 in the sample correlates with the presence of a neoplastic condition. Another method involves determining the risk of relapse, tumor
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Vertebral Body Cage
A intervertebral body device for supporting adjacent vertebrae includes a vertebral body member having at least one containment portion and one communicating portion. The containment portion and communication portion provide two distinct functional regions within the cage. One region of the cage pro
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LPS-Responsive CHS1/Beige-Like Anchor Gene and Therapeutic Applications Thereof
The present invention relates to a novel LPS-responsive and Beige-like Anchor gene (lrba), variants of the lrba gene, fragments of the lrba gene, and polypeptides encoded thereby. The subject invention also pertains to lrba interfering RNA, and uses thereof. In another aspect, the present invention
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CT Atlas of the Brisbane 2000 System of Liver Anatomy for Radiation Oncologists
The method includes the steps of obtaining atlas data in an atlas coordinate set from a computer-readable atlas of hepatic anatomical information including three orders of division. The three orders of division include a first order separating the liver into two (right and left) hemi-livers, a secon
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Human Mast Cell Line and Uses Thereof
The subject invention pertains to the development of a novel human mast cell line, USF-MC1. USF-MC1 is a mast cell precursor present in human umbilical cord blood (HUCB) that may be sustained in culture in the absence of exogenous cytokines to serve as a convenient experimental model of human mast c
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Genotypic Tumor Progression Classifier and Predictor
Actively dividing tumors appear to progress to a life threatening condition more rapidly than slowly dividing tumors. Assessing actively dividing tumors currently involves a manual assessment of the number of mitotic cells in a histological slide prepared from the tumor and assessed by a trained pat
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A Method and Composition Using a Dual Specificity Protein Tyrosine Phosphatase As an Antimalarial Drug Target
Phosphotyrosine phosphatase (PTP) encoded by PF13_0027 is a desirable drug target for the human malaria parasite Plasmodium falciparum. This PTP is critical for intraerythrocytic parasite development and invasion of erythrocytes by malaria merozoites. Mutation of the PF13_0027 gene or blocking expre
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Ionic Liquid Mediated Sol-gel Sorbents
Ionic liquid (IL)-mediated sol-gel hybrid organic-inorganic materials present enormous potential for effective use in analytical microextraction. One obstacle to materializing this prospect arises from high viscosity of ILs significantly slowing down sol-gel reactions. A method was developed which p
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Total Internal reflection Holographic Microscope
The present invention provides for a digital holographic microscope using a holographic interferometer and incorporating a TIR sample mount and microscopic imaging optics. The microscope uses phase shifting from frustrated internal reflection within a prism to measure nanometric distances. The inven
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Wet Etching Process
The present invention illustrates a bulk silicon etching technique that yields straight sidewalls, through wafer structures in very short times using standard silicon wet etching techniques. The method of the present invention employs selective porous silicon formation and dissolution to create high
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Practical Method of CO2 Sequestration
A process and device to capture of CO2 at its originating source, such as a power plant, is disclosed. Absorbent material is recharged by desorbing CO2, so that it may be sequestered or used in another application. Continual recharging results in loss of absorbent surface area, due to pore plugging
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Phase Change on Demand Integrated Pressure Pump and Power Plant
Activation of a propellant in a constant volume container causes a phase change material to rapidly expand so that the pressure in the container increases. Programmability and sequential actuation are enabled by patterning the phase change material into the integrated device. The pressure generated
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Immunotherapy for Treatment of Amyloid-Related Disorders Using Encapsulated Beta-Amyloid Peptides
The present invention relates to the field of polymer chemistry and more particularly to encapsulated peptides and uses thereof.
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Method for Diagnosing Selected Adenocarcinomas
A method for the early diagnosing of selected adenocarcinomas in a human comprising the steps of removing a bodily sample from the human, and assaying the bodily sample for elevated expression of a specific gene. The gene being assayed for in the bodily sample is the TGFB-4 gene (hereinafter referre
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Bladder Drainage Aid
Provided is a bladder drainage aid which attaches to the end of Foley Catheter and removes the need for a catheter bag. In a preferred embodiment, the device is a spring-loaded valve with an inflow tube and an outflow tube. The inflow tube connects to the external end of a catheter. The outflow tube
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Methods of Treating Stroke Using Stem Cell-like Menstrual Blood Cells
A cell type that is a complete match of the transplant recipient appears as an optimal scenario to open treatment options to a large patient population with minimal complications. The use of autologous bone marrow or umbilical cord blood has been proposed as a good source of stem cells for cell ther
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Cytotoxin Compound and Method of Isolation
The present invention concerns compounds derived from tunicates of the species Synoicum adareanum, as well as to pharmaceutical compositions comprising these compounds and methods of use. Extracts from tunicates show selective toxicity against several different cancer cell lines in the NCI 60 cell l
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Self-propelled Sensor Apparatus for in Situ Analysis of Enviromental Parameters
A submersible, self-propelled apparatus for analyzing a component contained in a liquid medium. The submersible, self-propelled apparatus uses kinetic energy of the apparatus to drive a liquid under analysis through the apparatus. This is accomplished by use of a conveyance system that is attached t
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N,n'-di-p-bromophenyl Guanidine Treatment for Stroke At Delayed Timepoints
1,3 di-o-tolylguanidine (DTG) was examined as anti-stroke drug with a broad therapeutic window. DTG activates sigma 1 and 2 receptors. Administration of DTG at 24 hours post- stroke to rats reduces neurodegeneration by 85%; this is the only pharmacological agent that has been used successfully at th
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Method of Modulating Ship Activity
A method of treating or preventing an immune disorder, such as graft versus host disease, in a subject. The method includes the administering a SHIP1 inhibitor, such as 3a-aminocholestane, to a subject in need of treatment. Thus, SHIP1 inhibitors taught herein represent a novel class of small molecu
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Method of Activating Nk Cells
The present invention provides a method of mediating hypo-activation of NK cells. Methods of the present invention comprise administering to a subject an effective amount of broad acting phosphotase inhibitor, such as sodium orthovanadate, SHP specific inhibitor. In one embodiment, the SHP specific
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Methods of Detecting and Treating Colon Disorders
The subject invention pertains to a method of detecting colon disorders including inflammatory bowel disease, such as Crohn's disease and ulcerative colitis, based on underexpression of Lipopolysaccharide Responsive Beige-like Anchor (LRBA). Advantageously, the invention may be used to test for infl
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Materials and Methods for Preventing Or Treating Neurodegenerative Conditions Associated with Abeta Peptide Accumulation
The subject invention concerns methods for preventing and/or treating neurodegenerative conditions associated with Abeta peptide accumulation in neural tissue in a human or animal. The subject invention also concerns methods for preventing or treating Alzheimer's disease-like neuropathology in a per
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Materials and methods for diagnosis, prevention and/or treatment of stress disorders and conditions associated with abeta peptide aggregation
The subject invention concerns materials and methods for treating and/or preventing diseases associated with accumulation of A[beta] peptide in neural tissue. The subject invention also concerns materials and methods for treating and/or preventing stress disorders, such as post-traumatic stress diso
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Asymmetric Cyclopropanation of Electron-deficient Olefins with Diazo Reagents
Cobalt-catalyzed asymmetric cyclopropanation of electron-deficient olefins.
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Akt and Clusterin As Biomarkers of Chemotherapeutic Responsiveness
Compositions and methods for identifying cancers resistant to treatment due to the presence of elevated pAKT levels and/or overexpression of AKT. The methods comprise the detection of active phosphorylated (p)AKT in a cell or sample of cells. The methods can further include treating the patient with
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Cobalt-Catalyzed Asymmetric Cyclopropanation of Alkenes with alpha-Nitrodiazoacetates
A process for the cyclopropanation of olefins with a metal porphyrin catalyst and an acceptor/acceptor substituted diazo reagent.
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Neurodegenerative Disease Treatment Using JAK/STAT Inhibition
The invention relates to treatment of neurodegenerative diseases with JAK/STAT pathway inhibitors to eliminate extracellular cell signaling events leading to cell cycle abrogation and/or apoptosis. Primary neurons were administered neurotoxic proteins, such as gp120, Tat, or gp120 and Tat, with or w
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Inhibition of Cell Proliferation
Compounds of formula (I) and (II) are provided as modulators of Rb:Raf-1 interactions which are potent, selective disruptors of Rb:Raf-1 binding. Therapeutic methods of using the compounds, for example for treating or ameliorating a cell proliferation disorder such as cancer, are provided.
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Volume Exclusion Agent to Enhance Formation of Extracelluar Matrix
A method of enhancing the formation of extracellular matrix in culture. Cells in culture secrete most of the collagen into the media as unprocessed procollagen, i.e., the cells do not convert procollagen to collagen. In contrast, normal extracellular matrix deposition involves procollagen processing
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Computer System and Computer-Implemented Method for Providing Personalized Health Information for Multiple Patients and Caregivers
Personalized health information is provided by maintaining a patient profile over time and matching information from the patient profile to appropriate patient-centric information related to that patient's specific medical condition. The patient profile can include a variety of medical information.
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Growth Factor Binding Molecules
Growth factor binding molecules having a plurality of peptide loops attached to a non-peptide organic scaffold, preferably having pseudo-six amino acid peptide loops with four amino acid sidechains. The growth factor binding molecules specifically bind various growth factors and are suitable for tre
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Niosome-hydrogel Drug Delivery System
Localized drug delivery systems are effective means to administer therapeutic concentrations and controlled release of drugs. A delivery system consisting of non-ionic surfactant vesicles (niosomes) packaged within a biodegradable, temperature and pH sensitive hydrogel network was developed. Drug be
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Methods of Diagnosing and Treating Cancer.
The invention relates to methods of determining an appropriate cancer therapy for a subject based on intratumoral expression levels of Ribonucleotide Reductase M1 (RRM1) and thymidylate synthase (TS) gene expression, as well as to methods of predicting clinical outcome (prognosis) based on cytoplasm
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Control of Nk Cell Function and Survival By Modulation of Ship Activity
Inhibition of dendritic cell function in solid organ grafts or allogeneic bone marrow transplants prior to or during engraftment by blocking SH2-containing inositol phosphatase (SHIP) expression or function is taught as a method of abrogating immune rejection and thereby increasing the efficacy of e
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Sustained Modulation of Temperature of Self Heating Chemical System
Exothermic reactions are used in self heating products, such as food, beverages, and clothing. Temperature peaks are important as heat can cause user injuries or increase pressures within the heating container to unsafe levels. Disclosed is a composition that modulates chemical reactions by control
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Method of Predicting Non-Response to First Line Chemotherapy
The invention provides a method for determining a prognosis of colorectal cancer in a colorectal cancer patient, comprising classifying said patient as having a good prognosis or a poor prognosis using measurements of a plurality of gene products in a cell sample taken from said patient, said gene p
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Inhibitors of Akt/PKB with Anti-tumor Activity.
The subject invention concerns materials and methods for inhibiting the Akt/PKB pathway. In one embodiment, a compound of the invention inhibits kinase activity and/or phosphorylation levels of Akt proteins. The subject invention also concerns methods for inhibiting or killing a cancer cell or other
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Alpha-helix Mimetic Using a 2,5-oligopyrimidine Scaffold
Alpha-helix mimetics and associated methods of making are provided. These compounds are constructed using a 2,5-oligopyrimidine scaffold. The semi-rigid scaffold holds individual side chain-like residues in orientations that mimic the orientations of side chain residues of an ?-helical protein domai
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Hyperactive Variants of 5-aminolevulinate Synthase and Methods of Use
The rate of porphyrin biosynthesis in mammals is controlled by the activity of the pyridoxal 5'-phosphate-dependent enzyme 5-aminolevulinate synthase. Assuming the turnover in this enzyme is controlled by conformational dynamics at a highly conserved active site loop, a variant library was construct
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Conservative Logic Gate for Design of Quantum Dot Cellular Automata Circuits
A novel conservative gate especially suiting a Quantum Dot Cellular Automata (QCA) majority voter-based design. The input-to-output mapping of the novel conservative QCA (CQCA) gate is: P=A; Q=AB+BC+AC [MV(A,B,C)]; R=A'B+A'C+BC [MV(A',B,C)], where A, B, C are inputs and P, Q, R are outputs, respecti
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Reelin Rescues Cognitive Function
Disclosed are methods of influencing, and enhancing, cognitive function by increasing, and/or preventing interference with, Reelin levels as well as Reelin signaling. Cognitive function is improved, in a subject in need thereof, by administering a therapeutically effective amount of Reelin, a Reelin
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Hucbc Treatment of Amyloid Associated Disease
Administration of human umbilical cord blood cells (HUCBC) or HUCBC-derived plasma is used to treat amyloid-based diseases, such as Alzheimer's disease, Huntington's disease, cerebral amyloid antigopathy, and type-II diabetes. Modulating inflammatory reactions by infusing HUCBC resulted in a marked
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Alkene Aziridination
A process for the asymmetric aziridination of an alkene comprising treating the alkene with a sulfonyl azide, preferably trichloroethoxysulfonyl azide, in the presence of a cobalt(II) porphyrin.
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Polyphenol proteasome inhibitors, synthesis, and methods of use
The present invention relates to synthetic green tea derived polyphenolic compounds, their modes of syntheses, and their use in inhibiting proteasomal activity and in treating cancers. The present invention is also directed to pharmaceutical compositions useful in methods of inhibiting proteasomes a
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Intracranial Catheter and Methods of Use
A catheter assembly for intracranial treatment of a subject that includes an outer tube that may be connected to an infusion or osmotic pump and delivered through a bendable catheter to the target brain site of the subject. The assembly facilitates regular accurate placement of drug or compound deli
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Translational Manipulation Polyaxial Screw Head
A novel surgical screw is presented as a polyaxial, multiaxial, or monoaxial screw. The polyaxial screw allows versatile angulation between a bone anchor section and a screw body and allows the surgeon to attach a rod to the invention in a top-loading manner and manipulate the rod to accommodate a p
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Method and Composition for Modulating Canonical Wnt Pathway Using Folate and Inositol
The canonical Wnt signaling pathway is implicated in many disorders including neural tube defects, limb malformations, and heart defects, developmental disorders associated with alcohol exposure (fetal alcohol syndrome) or exposure to bipolar medications (i.e. lithium), wound healing, and Alzheimer'
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Compositions and Methods for Enhancing Neuroprotection Via Administration of Stem Cells and Blood Brain Barrier Permeabilizers
The present invention provides compositions and methods for enhancing the neuroprotective effect of umbilical cord blood cells. More particularly, the present invention provides methods of treating neurodegenerative disorders by administering umbilical cord blood cells and a substance capable of per
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Proteasome Inhibitors Having Chymotrypsin-like Activity
Disclosed herein is the use of HLM-008182, as well as its analogues formed via in-house synthesis, as a potent proteasome inhibitors. A new method was developed for HLM-008182 through a four-step protocol and the method was further optimized to a two step protocol. The synthesis in both protocols wa
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Prevention, Treatment, and Diagnosis of Alzheimer's Disease Through Electromagnetic Field Exposure
According to a first embodiment the invention includes a method of treating a neurological disorder, such as Alzheimer's Disease, in a subject in need thereof by positioning an electromagnetic field emitting source proximal to the subject and exposing the subject to an electromagnetic field having a
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Bone marrow-derived neuronal cells
Bone marrow stromal cells (BMSC) differentiate into neuron-like phenotypes in vitro and in vivo, engrafted into normal or denervated rat striatum. The BMSC administered into the ventricle did not remain localized to the site of the graft, but migrated throughout the brain and integrated into specifi
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