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Apparatus for Occipito-cervical Fixation Enabling Supplemental Occipital Bone Fixation
An apparatus for stabilization of a patient's head relative to the patient's neck joint includes an occi-cervical base member having a "C '-shaped central part and first and second attachment rods respectively connected to and extending transversely from free ends of the central part. An occiput att
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Methods and Compositions for Reducing Activity of the Atrial Natriuretic Peptide Receptor and for Treatment of Diseases
Methods, compositions and devices are provided by the present invention for reducing activity of a natriuretic peptide receptor and other signals. Therapeutic treatments are provided by use of polynucleotides encoding a natriuretic peptide or by regulating the expression of natriuretic peptide recep
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Reinforced Piezoresistive Pressure Sensor
A MEMS-based silicon pressure sensor for the ocean environment is presented. The invention is a multiple diaphragm piezoresistive pressure sensor for measuring the pressure of a liquid, comprising an inner deformable diaphragm formed on a silicon substrate, the inner deformable diaphragm having a fi
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Supramolecular Assemblies and Building Blocks
The present invention generally relates to supramolecular assemblies and their modes of synthesis. The supramolecular assemblies include a 1:8 ratio of a supermolecular polyhedral building block and a triangular molecular building block, the supermolecular polyhedral building block having points of
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Nanometer-scale Electromechanical Switch and Fabrication Process
The present invention describes nano-scale fabrication technique used to create a sub-micron wide gap across the center conductor of a coplanar waveguide transmission line configured in a fixed-fixed beam arrangement, resulting in a pair of opposing cantilever beams that comprise an electro-mechanic
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Urodilatin Cancer Treatment
Urodilatin, a peptide formed in the kidney, has significant anticancer effects eliminating two-thirds of cancer cells within 24 hours.
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Methods for Detecting Or Monitoring Cancer Using LPC As a Marker
A method of detecting a cancer, such as ovarian cancer, in a test subject including (a) determining the amount of a lysophosphatidyl choline in a sample of a bodily fluid taken from the test subject, and (b) comparing the amount of the lysophosphatidyl choline in the sample of the bodily fluid taken
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Ship Inhibition to Direct Hematopoietic Stem Cells and Induce Extramedullary Hematopoiesis
The present invention concerns inhibition of SHIP expression and/or function in mammalian subjects to direct HSC from the bone marrow to other sites in the body (such as the spleen and/or liver), where they then re-establish blood cell production. The method of the invention can be employed, for exa
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Method of Selectively Inhibiting PKCiota
PKCiota inhibitor1 H-imidazole-4-carboxamide, 5-amino-1 -[2,3-dihydroxy-4-[(phosphonooxy) methyl] cyclopentyl] -,[1 R-(1a, 2ss, 3 ss, 4 a)], (ICA-1 ), targets a unique sequence (amino acid residues 469-475) in the catalytic domain of PKCiota and inhibits PKCiota activity. The data shows suprising an
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Gene Signature for the Prediction of Radiation Therapy Response
Described are mathematical models and method, e.g., computer-implemented methods, for predicting tumor sensitivity to radiation therapy, which can be used, e.g., for selecting a treatment for a subject who has a tumor.
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Device and Method to Facilitate Directed Delivery and Electroporation Using a Charged Stream
A method for facilitating a delivery of a molecule into an interior space of a cell includes the steps of introducing a molecule into a biological structure comprising a cell and applying a substantially continuous low-level electric field, in the form of non-thermal plasma (ionized gas) generated b
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Detection of Polyketide Synthetase Gene Expression in Karenia Brevis
The present invention concerns an assay for the detection of polyketide synthetase (PKS) mRNA from the red tide dinoflagellate Karenia brevis. Another aspect of the invention concerns NASBA primers and a molecular beacon that enable detection of mRNA of one of the PKS genes. In another aspect, the p
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Cobalt-catalyzed Asymmetric Cyclopropanation of Electron-deficient Olefins
Cobalt-catalyzed asymmetric cyclopropanation of electron-deficient olefins.
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Roofing Cap System
A low profile multi-vented steel hip and ridge cap system produced from durable 26 gauge Galvalume steel, then stone coated to match any composition shingle or metal roofing manufactures products. The ridge cap provides a beautiful, durable and low profile design that blends with the roof finish. It
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Simultaneous Sample Manipulation and Sensing using Surface Acoustic Waves
The present invention provides a hexagonal, delay line surface acoustic wave device fabricated on a a piezoelectric substrate, such as lithium tantalate, coated with an insulating waveguide on to which a sensing film, such as an anti-human Interleukin-6 biosensor film, is physically absorbed. The ac
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Cartesian Human Morpho-informatic System
The present invention is a three dimensional Cartesian coordinate system for the human body, having three perpendicular and intersecting planes. The present invention is based upon the use of the three cardinal planes, in the universally recognized orientations. The cardinal planes in accordance wit
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Enantioselective Ring-opening of Aziridines
A process for the preparation of a nucleophilic addition product of an aziridine and a nucleophile, the process comprising treating the arizidine with the nucleophile in the presence of a biaryl phosphoric acid catalyst.
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Combined Fiber-optic Absorption and Emission Measurement Apparatus
Disclosed is a spectroscopic system having a fiber-optic probe for simultaneous IR and Raman measurement. The probe includes a single strand of optical fiber, such as sapphire which is suitable for IR absorption measurements as far as 4 [mu]m and Raman excitation at wavelengths as short as 300 nm. T
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Derivative N-thiolated 2-oxazolidinone Antibiotics
This invention describes the discovery and synthesis of N-thiolated 2-oxazolidinones as a new class of anti bacterial agents. These compounds can be synthesized from 2-oxazolidinones by Ndeprotection and N-sulfenylation. These new substances were found to exhibit potent anti-bacterial activity, incl
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Delta-tocotrienol Treatment and Prevention of Pancreatic Cancer
Methods are disclosed for treating neoplastic disorders, such as pancreatic cancer, using tocotrienols; namely, gamma-tocotrienol and delta tocotrienol. The antitumorogenic effects of these compounds are shown both in vitro and in vivo using several human pancreatic cancer cell lines and MIA-PAC A2
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Method of Treating Chronic Myelogenous Leukemia Cells
Here, the inventors disclose the treatment of imatinib mesylate resistant chronic myelogenous leukemia cells with a cotreatment of vorinostat (SAHA, suberoylanilide hydroxamic acid) and dasatinib, a dual Abl/Src kinase (TK) inhibitor. Combined treatment of cultured human CML and BaF3 cells with vori
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Alignancy-risk Signature from Histologically Normal Breast Tissue
The invention provides for malignancy-risk gene signatures that predict the risk of developing breast cancer, the recurrence of breast cancer, and/or the metastasis of breast cancer. These signatures have numerous clinical applications including assessing risk of breast cancer development following
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Radio Guided Seed Localization of Imaged Lesions
A method of removing lesions by implanting a radioactive seed at the location of the lesion, locating the lesion with the radioactive seed, and removing the lesion with the radioactive seed.
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Nanoparticle Targeted Drug Delivery to the Lungs Using Extra-testicular Sertoli Cells
A method of delivering a compound of interest to the lungs of a subject by the intravenous injection of Sertoli cells loaded with a plurality of chitosan nanoparticles coupled with the compound of interest is provided. Testis-derived rat Sertoli cells were pre-loaded with chitosan nanoparticles coup
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Triazoles and Processes for Producing the Same
The present disclosure relates to triazoles and processes for their preparation. The processes involve a target-guided synthesis approach, whereby an alkyne and an azide are reacted in the presence of a biological target protein, a Bcl-2 family protein, to form the triazole.
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Acylsulfonamides and Processes for Producing the Same
The present disclosure relates to acylsulfonamides and processes for their preparation. The processes involve a target-guided synthesis approach, whereby a thioacid and a sulfonyl azide are reacted in the presence of a biological target protein, a Bcl-2 family protein, to form the acylsulfonamide.
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Method for the Modulation of Function of Transcription Factors
There is provided a method of modulating the function of transcription factor by administering an effective amount of an oligonucleotide containing optimal nucleotide binding sites for the transcription factor. A therapeutic agent having an effective amount of an oligonucleotide for modulating funct
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Cobalt-catalyzed Asymmetric Cyclopropanation with Diazosulfones
Asymmetric cyclopropanation of olefins with diazosulfones.
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Methods of Treating Disease-induced Ataxia and Non-ataxic Imbalance
Methods for treatment of disease-induced ataxia and non-ataxic imbalance are disclosed. The methods involve treating a patient with a compound having nicotinic acetylcholine receptor activity.
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Interactive Pin Array Device - Webnail
An innovation in the communication field. After hearing, seeing you can now touch via Internet!
An interactive pin array device comprising a plurality of elongated pins held in a frame and forming a set. The frame is adapted to hold the plurality of pins in a parallel position to one another in a
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STAT3 Agonists and Antagonists and Therapeutic Uses Thereof
The present invention relates to methods for modulating, i.e., agonizing or antagonizing, Stat3 (Signal Transducer and Activator of Transcription3) signaling activity for use in gene therapy. Inhibition and/or activation of Stat3 signaling is an effective approach to modulate angiogenesis and the im
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Clathrate Compounds and Methods of Manufacturing
The present invention comprises new materials, material structures, and processes of fabrication of such that may be used in technologies involving the conversion of light to electricity and/or heat to electricity, and in optoelectronics technologies. The present invention provide for the fabricatio
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Inhibition of Shp2/PTPn11 Protein Tyrosine Phosphatase By Nsc-117199 and Analogs
Protein tyrosine phosphatase (PTP) Shp2 is a non-receptor PTP that involved in cell signaling and regulation of cell proliferation, differentiation, and migration. Shp2 mediates activation of kinases that are involved in the pathogenesis of human carcinoma. NSC-117199 was identified as a porent inhi
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Substrate-mimetic Akt Inhibitor
Disclosed herein is a species of peptide and non-peptide inhibitors of Akt, an oncogenic protein. Beginning with a residue of Akt target substrate GSK-3, the functional domains of the GSK-3 residue were characterized. Functionally homologous non-peptide groups were substituted for the amino acids of
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Use of SH2 STAT3/STAT1 Peptidomimetics as Anticancer Drugs
The subject invention concerns compositions and methods for blocking cancer cell growth or proliferation and/or inducing cancer cell death. Compositions of the present invention are peptidomimetics that inhibit STAT function. Peptidomimetics of the invention display selective inhibition of specific
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Interferometric Chemical Sensor Array
The device is a gas/vapor/aerosol/particulate sensor with a receiver/transmitter option. This optical MEMS device is designed to be a self-contained optical bench, integrating of an entire interferometer into a MOEMS 'optical bench' system-on-a-chip, and includes multiplexed optical path sensors. Th
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Proteasome Inhibitors for Selectively Inducing Apoptosis in Cancer Cells
The subject invention concerns compounds having activity as inhibitors of proteasomes and methods of using the subject compounds. In one embodiment, a compound of the invention has the chemical structure shown in Formula (I), wherein R1 is an organic cyclic ring structure bonded to a sulfonamide str
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Indoline Scaffold Shp-2 Inhibitors and Cancer Treatment Method
The subject invention concerns methods and compounds for inhibiting Shp2. In one embodiment, a compound of the invention has a chemical structure as shown in formula I or II: wherein X, Y, and Z are independently N or S; R1 is cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, any of which can be op
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Regulatory B Cells and their Uses
The present invention relates to a phenotypically distinct CD1dhigh CD5+ B cell subset that regulates T cell mediated inflammatory responses through the secretion of interleukin-10 (IL-IO). The invention also relates to the use of these IL-IO producing regulatory B cells in the manipulation of immun
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Trimodal Cancer Therapy
Cancers are treated with three types of agents: a chemotherapeutic agent which induces lymphopenia; an inhibitory antibody to a surface marker on Treg cells; and an anti-cancer vaccine. This combination may lead to enhanced immune responses despite lymphodepletion.
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Systems and Methods for Generating an Osteoarthritis Progression Predictor and Systems and Methods for Using the Predictor
Example systems and methods of generating an indicator of osteoarthritis (OA) progression are described. Fractal dimension curves are generated for horizontal and vertical trabecular components associated with a region of interest of a joint image. A statistical model is used to model shapes of the
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Metamaterials for Surfaces and Waveguides
Complementary metamaterial elements provide an effective permittivity and/or permeability for surface structures and/or waveguide structures. The complementary metamaterial resonant elements may include Babinet complements of "split ring resonator" (SRR) and "electric LC" (ELC) metamaterial elements
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Therapeutic Agents for Neurodegenerative Diseases
Methods of treating diseases involving protein aggregation are provided. Methods of identifying and selecting an autophagosome/lysosome fusion enhancer are also provided.
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Up and Down Conversion Systems for Improved Solar Cell Performance Or Other Energy Conversion
A system and a conversion element for power conversion. The power conversion system includes a power conversion device which produces electric power upon illumination and includes a light conversion device which down-converts and up-converts a radiant source of energy into a specific energy spectrum
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Functionalized Metal-coated Energy Converting Nanoparticles, Methods for Production Thereof and Methods for Use
A functionalized nanoparticle, having a core, optionally having a shell on at least a portion thereof, wherein the core contains a material that can convert applied X-ray energy into emitted UV energy and wherein the shell, when present, contains a plasmonics active material; wherein the nanoparticl
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Method for Treating Obesity
The present invention relates, in general, to obesity, and, in particular, to a method of treating obesity and minimizing metabolic risk factors associated therewith using, for example, zonisamide or other weight-loss promoting anticonvulsant either alone or in combination with bupropion or other co
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Viral Microrna
The present invention relates, in general, to micro RN As and. in particular, to viral microRNAs expressed by Herpes Simplex Vims 1 (HSV-1) or Herpes Simplex Virus 2 (HSV-2), to agents that inhibit such microRNAs and to methods of treatment based on the use of such agents.
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Reversible Platelet Inhibition
The present invention relates, in general, to receptors and to platelet aggregation and, in particular, to a method of inhibiting platelet aggregation using an aptamer that binds to and inhibits the activity of a receptor, such as glycoprotein IIb/IIIa (gpIIb/IIIa), and to aptamers suitable for use
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Urate Oxidase
The present invention relates, in general, to urate oxidase (uricase) proteins and nucleic acid molecules encoding same. In particular, the invention relates to uricase proteins which are particularly useful as, for example, intermediates for making improved modified uricase proteins with reduced im
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Composition and Methods for Eliciting an Immune Response
The present invention relates to compositions, methods, and kits for eliciting an immune response, in particular for eliciting an immune response to at least one antigen expressed by a cancer cell, in particular for treating and preventing cancer.
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Compositions and Methods Relating to Heat Shock Transcription Factor Activating Compounds and Targets Thereof
The present invention relates to HSF activating compounds, methods for their discovery, and their research and therapeutic uses, as well as pharmaceutically acceptable salts, solvates, chelates, non-covalent complexes, prodrugs, mixtures (including both R and S enantiomeric forms and racemic mixture
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Elastin-like polypeptide and gadolinium conjugate for magnetic resonance imaging
A magnetic resonance imaging (MRI) contrast enhancement agent comprising an elastin-like polypeptide (ELP) and one or more paramagnetic metal ions is disclosed. Also disclosed are methods of preparing ELP MRI contrast enhancement agents, formulations comprising ELP MRI contrast enhancement agents, a
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Integrated Droplet Actuator for Gel Electrophoresis and Molecular Analysis
The invention is directed to a droplet actuator device and methods for integrating gel electrophoresis analysis with pre or post-analytical sample handling as well as other molecular analysis processes. Using digital microfluidics technology, the droplet actuator device and methods of the invention
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Multi-photon Microscopy Via Air Interface Objective Lens
The present disclosure provides an optical system for depth-resolved imaging of a specimen such as living tissue in vitro (e.g., brain tissue). The optical system comprises a confocal and multi-photon microscope having an objective with adjustable glass correction and a gas between the objective len
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Treatment for Diseases Relying on Discovery That Thioredoxin Mediates Nitric Oxide
Patients having a disease associated with high level of thioredoxin system activity or a requirement for nitric oxide, e.g. large cell lymphoma or restenosis, are treated with a thioredoxin reductase inhibitor, e.g. auranofin or arsenic trioxide, and a nitric oxide donating compound, e.g. isosorbide
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Diffuse Reflectance Spectroscopy Device for Quantifying Tissue Absorption and Scattering
A diffuse reflectance spectroscopy system for quantifying electromagnetic absorption and scattering in a tissue is provided. Also provided are optical probes and methods for imaging a tissue mass. In some embodiments, the methods include the steps of contacting a tissue mass with an optical probe, w
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Anti-CD19 Antibodies and Uses in B Cell Disorders
The invention relates to immunotherapeutic compositions and methods for the treatment of B cell diseases and disorders in human subjects, such as, but not limited to, B cell malignancies and autoimmune diseases and disorders, using therapeutic antibodies that bind to the human CD19 antigen and that
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Polyvalent Vaccine
The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets
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RNA aptamers and methods for identifying the same
RNA aptamers and methods for identifying the same are disclosed. The RNA aptamers selectively bind coagulation factors, E2F family members, Ang1 or Ang2, and therapeutic and other uses for the RNA aptamers are also disclosed.
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Prevennting the Occurrence of Obesity
Administration of autophagy inhibitor (e.g. 400 mg chloroquine daily) prevents occurrence of obesity and insulin resistance in human subject on prolonged high-fat diet.
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Betulinic Acid Derivatives As Anti-HIV Agents
The present invention provides compounds of the general structure: which are substituted at the 3 and 28 positions, along with pharmaceutical formulations containing the same and methods of treating viral infections employing the same.
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A Method of Detecting Antibodies and Antibody-hiv Virion Complexes
The present invention relates, in general, to HIV and, in particular to a method of detecting anti-HIV antibodies and antibody-HIV virion complexes.
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Hematopoietic Stem Cell Growth Factor
The present invention relates, in general, to stem cells and, in particular, to a hematopoietic stem cell (HSC) growth factor and to methods of using same.
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Method of Inducing an Anti-viral Immune Response
The present invention relates to a method of inducing an anti-viral immune response. The method comprises administering to a patient in need thereof an antigen that induces the production of antibodies that, upon binding to a cell surface target, result in the production of chemokines that inhibit v
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Anti-lipid Antibodies
The present invention relates, in general, to anti-lipid antibodies and, in particular, to methods of inhibiting HIV-I infection using anti-lipid (e.g. anti-phospholipid) antibodies.
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Inhibiting GS-FDH to Modulate No Bioactivity
Patients needing NO donor therapy or inhibition of pathologically proliferating cells or increased NO bioactivity are treated with a therapeutically effective amount of an inhibitor of glutathione-dependent formaldehyde dehydrogenase.
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Systems and Methods for Determining Hemoglobin Concentration Utilizing Diffuse Reflectance At Isosbestic Wavelengths
Systems and methods for determining hemoglobin concentration utilizing diffuse reflectance at isosbestic wavelengths are provided. In one embodiment, the method includes emitting light onto a tissue mass, measuring diffuse reflectance from the tissue mass, and calculating a ratio of diffuse reflecta
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Microrna and Use Thereof in Identification of B Cell Malignancies
Disclosed are nucleic acid sequences, including microRNA sequences and cDNA sequences, as well as vectors, DNA libraries, microarrays, and recombinant cells comprising the nucleic acid sequences described herein. Methods of determining the B cell stage from which a B cell malignancy is derived. Meth
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Compositions and Methods for Enhancing Odorant Receptor Activity
The present invention relates to polypeptides capable of modulating odorant receptor activation. In particular, the present invention provides polypeptides (e.g., type 3 muscarinic actetylcholine receptor M3) capable of enhancing odorant receptor activation. The present invention further provides as
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Tunable Metamaterials
Examples of the present invention include a metamaterial comprising a plurality of resonators disposed on a substrate, the substrate comprising a dielectric support layer and a relatively thin semiconductor layer, having a Schottky junction between at least one conducting resonator and the semicondu
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Methods and Compositions for Correlating Genetic Markers with Cardiovascular Disease
The present invention provides methods of identifying a subject having an increased or decreased risk of developing cardiovascular disease, comprising: a) correlating the presence of one or more genetic markers in chromosome 3q13.31 with an increased or decreased risk of developing cardiovascular di
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Methods and Compositions for Treating Urinary Tract Infections Using Agents That Mimic Or Elevate Cyclic Amp
Methods and compositions are provided for treating a urinary tract infection (UTI). The methods involve administering to a subject in need thereof a cAMP elevator or agent that mimics cAMP, particularly a labdane diterpene such as forskolin or a derivative or analog thereof in a therapeutically effe
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Peg-urate Oxidase Conjugates and Use Thereof
A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5
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Inhibition of Inter-alpha Trypsin Inhibitor for the Treatment of Airway Disease
It is disclosed herein that blockade of inter-alpha-trypsin inhibitor (IaI) prevents the development of airway hyperresponsiveness in animal models of asthma and chronic obstructive pulmonary disease. Provided herein are methods of treating an airway disease or disorder in a subject by administering
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Assessing Pulmonary Gas Transfer in Lungs Using Hyperpolarized 129Xe MRI
A method for providing MRI data of pulmonary gas exchange and/or alveolarcapillary barrier status is disclosed. The method comprises transmitting an RF MRI excitation pulse imaging sequence configured to excite dissolved phase hyperpolarized 129Xe in a gas exchange region of a lung of a subject; and
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Non-regular Electrical Stimulation Patterns for Treating Neurological Disorders
Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. Compared to conventional continuous, high rate pulse trains having re
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Systems and Methods for Endoscopic Angle-resolved Low Coherence Interferometry
Fourier domain a/LCI (faLCI) system and method which enables in vivo data acquisition at rapid rates using a single scan. Angle-resolved and depth-resolved spectra information is obtained with one scan. The reference arm can remain fixed with respect to the sample due to only one scan required. A re
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Compositions and Methods for Growing Copper Nanowires
A method of synthesis to produce gram-scale quantities of copper nanowires in an aqueous solution, wherein the copper nanowires are dispersed in said solution. Copper nanowires grow from spherical copper nanoparticles within the first 5 minutes of the reaction. Copper nanowires can be collected from
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Lsamp gene associated with cardiovascular disease
The LSAMP gene can be used for cardiovascular disease risk assessment, in particular Left Main Disease. The genetic risk attributable to LSAMP adds to known cardiovascular disease risk factors. Assessment of risk attributable to LSAMP permits early initiation of preventive and therapeutic strategies
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Immunomodulating gene therapy
The present invention relates, in general, to Pompe disease and, in particular, to a methods of treating Pompe disease and to compounds/constructs suitable for use in such methods.
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Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with RNA
The present invention relates to methods for producing an RNA-loaded antigen presenting cell (APC), said method comprising introducing into an antigen presenting cell in vitro RNA encoding an immunomodulator. The present invention also relates to RNA-loaded APCs obtainable by such methods.
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Novel Medical Uses for No and No Donor Compounds
A body part is preserved using nitric oxide and/or a nitric oxide donor that does not directly release nitric oxide or a red blood cell nitrosylating agent, preferably ethyl nitrite to facilitate oxygen supply. A subject at risk for developing high altitude illness is administered a red blood nitros
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Substituted porphyrins and their therapeutic use
The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and composit
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Stem Cell Derived Factors for Treating Pathologic Conditions
A purified paracrine factor of a mesenchymal stem cell, such as a Secreted frizzled related protein (Sfrp) is useful to reduce cell death an/or tissue injury associated with ischemic condtions.
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Bisphosphonate Compositions and Methods for Treating Heart Failure
The present invention provides for methods and compositions for treating and/or preventing cardiac dysfunction by administering to subject a therapeutically effective amount of a bisphosphonate, functional analogue or a pharmaceutically effective salt thereof.
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Compositions, Methods, and Kits for Determining an Alkyl Transferase
The present invention relates to novel compounds as well as to compositions, methods, and kits comprising the compounds for determining an alkyltransferase (ATase), in particular an alkylguanine-DNA alkyl transferase (AGT). In general, the novel compounds provide for determining ATase levels, in par
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Compositions and Methods for the Treatment of Radioresistant Glioma Stem Cells
Compositions and uses of gamma secretase inhibitors (GSIs) for the treatment and inhibition of gliomas in subjects in need thereof are provided. Methods for administering gamma secretase inhibitors in association with radiation for the treatment of radiation resistant gliomas are described. Composit
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Droplet-based Biochemistry
The present invention relates to a droplet microactuator and to systems, apparatuses and methods employing the droplet microactuator for executing various protocols using droplets. The invention includes a droplet microactuator or droplet microactuator system having one or more input reservoirs load
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Inhibition of HIF-1 activation for anti-tumor and anti-inflammatory responses
The presently disclosed subject matter generally relates to methods and compositions for inhibiting the expression and/or activation of hypoxia-inducible factor 1 (HIF-1) genes in a cancer cell, tissue or tumor. More particularly, the methods disclosed herein relate to inhibition of HIF-1 activation
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Tissue Engineering
The present invention relates, in general, to tissue engineering and, in particular, to a method of extending the lifespan of cells suitable for use in vascular engineering.
The present invention relates to a method of producing vascular grafts. The method comprises introducing into cells an expr
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Acoustic Lens for Shockwave Lithotripsy and Related Methods
Systems and methods for providing therapeutic shock waves are provided. A modified acoustic lens can include a first lens portion for directing a first part of an acoustic shock wave pulse toward a target and a second lens portion for directing a second part of the acoustic shock wave pulse toward t
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Cell Coated Implantable Device
The present invention relates, in general, to a cell-coated implantable medical device and, in particular, to an implantable medical device the blood-contacting surfaces of which are coated with endothelial progenitor cells (EPCs). In a preferred embodiment, the medical device is a titanium or titan
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CD20-specific Antibody and Method of Employing the Same
The present invention provides monoclonal antibodies and antigen-binding fragments thereof that specifically bind to CD20, as well as pharmaceutical compositions comprising the same. The invention further provides methods of using the monoclonal antibodies, antigen-binding fragments, and pharmaceuti
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Use of an Agent That Restores Tissue Perfusion and Oxygenation
The presently disclosed subject matter provides methods for increasing perfusion in hypoxic regions of tissues in subjects. Also provided are methods for treating diseases and/or disorders associated with hypoxia in subjects, methods for increasing sensitivity of tumors to radiation and/or chemother
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Compositions and Methods for Inhibiting Hair Growth
A method for inhibiting hair growth in mammals using compositions containing FP receptor antagonists (e.g., prostaglandin F analogs that are block activation of the FP receptor). The compositions can be applied topically to the skin and/or hair. The compositions can arrest hirsutism or hypertrichosi
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Prochelators Useful for Inhibiting Metal-associated Toxicity
Prochelator compounds of Formula (I) or Formula (II) are described, along with methods of using the same and pharmaceutical formulations or compositions containing the same.
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Conjugates prepared with aggregate-free proteins
A naturally occurring or recombinant protein, especially a mutein of porcine urate oxidase (uricase), that is essentially free of large aggregates can be rendered substantially non-immunogenic by conjugation with a sufficiently small number of strands of polymer such that the bioactivity of the prot
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Compositions, Methods and Kits for Eliciting an Immune Response
The present invention relates to compositions, methods, and kits for eliciting an immune response to at least one CMV antigen expressed by a cancer cell, in particular for treating and preventing cancer. CMV determination methods, compositions, and kits also are provided.
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Smoothened Receptor Modulators
The present invention relates, in general, to the Smoothened receptor and, in particular, to a method of modulating Smoothened receptor activity and to compounds and compositions suitable for use in such a method.
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C16 Unsaturated FP-selective Prostaglandin Analogue
PROBLEM TO BE SOLVED: To provide a new PGF (prostaglandin F) analogue useful in treating various diseases and symptoms including bone disorders. ; SOLUTION: A compound having a structure in accordance with formula (I) is provided. Besides, optical isomers, diastereomers and enantiomers of formula (I
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