PATENTS
For Sale or License
Notify me of New Entries
Receive an email whenever a new patent is added.
You can unsubscribe at any time.
NEW 110mpg HP2g™ HYBRID Internal combustion engine and method of operating same # US 8616175 B2
** US 8616175 Patent with International applications also
An internal combustion engine and a method for maximizing fuel efficiency of an internal combustion engine. The internal combustion engine includes an engine block assembly having an electromagnet coupled thereto and an engine component mo
...
Respiratory Detection System (RDS)
Introduction Respiration rates are an important indicator of cellular and metabolic states in cells ranging from mammalian to bacterial, from individuals to large populations. Unfortunately, conventional techniques have significant drawbacks: for instance, electrochemical techniques have low sensiti
...
Advanced Biomimetic Surfaces for Surface-Enhanced Raman Spectroscopy (SERS)
Introduction Raman spectroscopy characterizes molecules by their Raman scattering. As incoming light scatters off a molecule, most does so elastically, neither gaining nor losing energy, and this is known as Rayleigh scattering. Some of this light, however, about 1 in 10 million photons, is the subj
...
Universal Home Gym for Wheelchair Users
Rehabilitation and Fitness Solutions d/b/a Wheelchair Fitness Solution is seeking interested business to take our prototype to the next level to launch our revolutionary home gym system.
...
Tissue-Engineered Urinary Bladder Using Autologous Cells
Introduction There is a variety of reasons that a person’s bladder may fail or require removal, including bladder acontractility, cancer, and cystitis. Unfortunately, conventional artificial bladders tend to suffer from critical complications, such as inadequate performance, infection, and adverse h
...
Platelet Clotting Force Array
Introduction Advances in microfluidic technology are constantly opening doors to new and exciting applications, such as point-of-care diagnostic devices. These microscale diagnostic platforms will enable faster, cheaper, and more accurate patient evaluation for a wide array of parameters. One such p
...
ball retrieval sports racket
A convenient way to retrieve ball during play of pickle ball, ping pong or other sports.
Especially useful for people with difficulty bending over , such as elderly or handicapped.
The 3 m company and Elmers glue company have been looking into this but have not gotten back to me.
...
A System for Detecting, Monitoring, Recording and Transmitting Data on Power Consumption
The present invention aims at overcoming the above drawback and provides a system for detecting, monitoring, recording and transmitting data on power consumption, which comprises in combination - (i) means for observing power consumption such as an energy monitor (1); (ii) power control unit (2) rec
...
Microfluidic Platform for Assessment of Blood Coagulation
Introduction Advances in microfluidic technology are constantly opening doors to new and exciting applications, such as point-of-care diagnostic devices. These microscale diagnostic platforms will enable faster, cheaper, and more accurate patient evaluation for a wide array of parameters. One such p
...
A Microfluidic Device and Methodology for Rapid, Quantitative Determination of Analyte Concentration in a Fluid Sample
Introduction Advances in microfluidic technology are constantly opening doors to new and exciting applications, especially for biosensors and environmental monitoring. One recent area of interest is point-of-care diagnostic devices. These devices provide fast, accurate, and inexpensive sample analys
...
Wideband Transducer for Measuring a Broad Range of Currents in High Voltage Conductors
This patent describes an instrument that can measure currents almost anywhere but was invented primarily for electrical power systems. This instrument is called a magnetic field current sensor (MFCS). A website at www.frsconsulting.biz describes the instrument in detail and covers the development
...
Catheter for endovascular intervention
A University at Buffalo radiologist has developed novel stent vascular devices for the treatment of cerebral aneurysms. The nature of these neurovascular stents and other devices like them make deployment a real challenge. In addition to the stents , a truly novel and revolutionary deployment device
...
Skills Trainer for Robotic Surgery
Robotic surgery is becoming increasingly popular with the advent of robotic technology in medicine. With this, there arises a need to extensively train the surgeons to effectively use these devices. Surgeons using these robotic systems need to be tra ined for a large number of procedures before bein
...
In-Situ Stress-Strain Sensor
This invention describes a technology that provides a new class of strain/stress sensors. The sensors are short fiber composites. They provide a reversible electrical response to strain/stress application. The sensing material can function as the structure material at the same time, so no embedding
...
CPAP titration using artificial neural network
For 18 million Americans suffering from Obstructive Sleep Apnea (OSA) this is as frustrating as a dog chasing its tail. Lack of proper sleep can lead to severe health problems and increased risk of accidental death. Continuous Positive Airway Press ure (CPAP) provides effective treatment. However, d
...
Esophageal Coupling Rings
Esophageal atresia with tracheal esophageal fitula occurs in approximately 1 in 1500-5000 newborns. This is a congenital defect in which the esophagus does not form a continuous connection to the stomach and instead ends in a pouch. Without treatme nt, the condition is fatal. Current treatments invo
...
Intestinal Coupling Device
Esophageal atresia with tracheal esophageal fitula occurs in approximately 1 in 1500-5000 newborns. This is a congenital defect in which the esophagus does not form a continuous connection to the stomach and instead ends in a pouch. Without treatme nt, the condition is fatal. Current treatments invo
...
Non-Invasive Screening Device for Upper Aerodigestive Tract Neoplasia
Diagnostic medical equipments are probably one of the most important paraphernalias of the medical field. This is because of the fact that in all the medical procedures, diagnosis is the first step towards combating diseases. It assumes critical impo rtance when the diseases are of the nature that r
...
Security and driver/personnel identification system
US Patent 8,451,105 refers to a biometric cell phone and biometric cell phone receptor.
It is a known fact that in the transportation industry, drivers drive "over hours" to reach a facility before it closes, resulting in an overtired driver at increased risk of a highway accident, and the poss
...
720° analogue dial - invertible loop dial face
One time auction only - ends April 15, 2014. Worldwide licensing agreement or patent ownership valid until 2021.
Ownership of the world's first annular 720° dial. It is especially relevant for the clock industry, where timepieces could be endowed with the ability to mechanically change their face
...
Security and Tracking System for Cargo Containers
US Patent 7,414,527 refers to a Confirmation Security Pad and Weight Detection Sensor.
The primary purpose of the Confirmation Security Pad is to prevent theft and unauthorized activity.
The Confirmation Security (CS) Pad containing a weight detection sensor detects the presence and absence of
...
Optical Coherence Tomography: High-Resolution Balloon Catheter Imaging, Dispersion Management, and Lateral-Priority Real-Time Imaging and Focus Tracking
Introduction Optical coherence tomography (OCT) is an imaging technique that uses light to acquire three-dimensional images of biological tissue. This non-invasive technique generates highquality images in real time and easily integrates with existing endoscope technologies. It is commonly used to i
...
Screening for Drugs Targeting tRNA Synthetase
Introduction Dr Jonathan Gallant’s laboratory has developed biomaterials that identify specific tRNA deficiencies within cells. These biomaterials can be used to screen for compounds which inhibit tRNA synthetases, such as certain classes of antibiotics, as well as to ensure efficient protein expres
...
Cyclic Nucleotide Phosphodiesterase Family 10 / PDE10
Introduction Cyclic nucleotide phosphodiesterases (PDEs) are enzymes hydrolyzing the second messengers adenosine and guanosine 3',5'-cyclic monophosphates (cAMP and cGMP). The human genome encodes 21 PDE genes that are categorized into 11 families. Selective inhibitors against individual PDE familie
...
Fluorescent Microglial Cell Lines
Introduction Microglial cells are the resident immune cells of the central nervous system. Upon brain damage, these cells are rapidly activated and transform from a resting state into activated microglia. They share many properties with peripheral tissue macrophages, one of them being their inherent
...
SV2A/B Double Knockout Mouse
Introduction Synaptic vesicle protein 2 (SV2) is a membrane glycoprotein found only in the secretory vesicles of neural and endocrine cells. It appears to be unique to vertebrates, suggesting that it evolved as a part of complex signaling systems. In mammals, there are three SV2 genes denoted A, B,
...
Cyclic nucleotide phosphodiesterase 7B (PDE7B)
Introduction Cyclic nucleotide phosphodiesterases (PDEs) are enzymes hydrolyzing the second messengers adenosine and guanosine 3',5'-cyclic monophosphates (cAMP and cGMP). The human genome encodes 21 PDE genes that are categorized into 11 families. Selective inhibitors against individual PDE familie
...
SV2B Knockout Mouse
Introduction Synaptic vesicle protein 2 (SV2) is a membrane glycoprotein found only in the secretory vesicles of neural and endocrine cells. It appears to be unique to vertebrates, suggesting that it evolved as a part of complex signaling systems. In mammals, there are three SV2 genes denoted A, B,
...
Thrombospondin 2-null mice
Introduction Thrombospondin 2 (TSP2), a matricellular protein with a primary role in modulating cell matrix interactions, has been implicated in tissue repair and foreign body responses. Technology description TSP2-null mice were produced by targeted disruption of the thrombospondin 2 gene in embryo
...
cDNA clone Encoding a β1-subunit of a Brain Sodium Channel
Introduction The voltage-gated sodium channels that are responsible for action potential generation in central neurons are important targets for the actions of antiepileptic drugs. These channels consist of a complex of three glycoprotein subunits: a pore-forming α subunit associated noncovalently w
...
SirT1 Conditional Knockout Mice
Introduction SirT1 is a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase capable of modifying the activity of many transcription factors that have been implicated in the physiology and pathology of multiple organs. Researchers at the University of Washington have developed a strain of S
...
NPY-Deficient mice
Introduction NEUROPEPTIDE Y (NPY), a 36-amino-acid transmitter distributed throughout the nervous system, is thought to function as a central stimulator of feeding behaviour. NPY has also been implicated in the modulation of mood, cerebrocortical excitability, hypothalamic–
pituitary signalling, ca
...
A Yeast Ligand Sensor
Introduction The yeast ligand sensor is a novel approach for the detection and quantification of ligandbinding, an issue of great interest in drug discovery and other areas. The approach is a protein-derived biosensor in which the readout is a change in growth of temperaturesensitive yeast. The yeas
...
Type I Adenylyl Cyclase Knockout Mouse
Introduction The type I adenylyl cyclase (I-AC) is neurospecific and expressed in areas of the brain that show long-term potentiation. This enzyme is thought to play an important role in the development of the central nervous system, circadian rhythm, and memory formation. Technology description Dr.
...
B7-H-Ig Fusion Protein
Introduction T cell activation and differentiation require not only T cell receptor recognition of the antigen–MHC complex but also costimulation through the interaction of accessory molecules on APC and their corresponding receptors on T lymphocytes. CD28 is the most important costimulatory recepto
...
PDL2-Ig Fusion Protein
Introduction T cell activation and tolerance are critically regulated by costimulatory molecules, especially those in the B7 and CD28 superfamilies. PD-1, a novel member of the CD28 family, is expressed on activated T cells and B cells. PD-1 has been shown to be a negative regulator of T cell activa
...
Zinc Transporter-3 Knockout Mouse
Introduction The presence of histochemically reactive zinc within synaptic vesicles defines a subset of neurons that have been termed zinc-enriched (ZEN) neurons. Because ZEN neurons are prevalent throughout the limbic system and zinc is capable at physiological concentrations of exerting neuromodul
...
Type III Adenylyl Cyclase Gene Knockout Mice
Introduction The olfactory sensory system has the remarkable capacity to detect and discriminate among a wide array of odorants and translate them into cognitive representations. Cyclic nucleotide–gated ion channels in olfactory sensory neurons (OSNs) are hypothesized to play a critical role in olfa
...
A Mouse Model for Osteoporosis
Introduction Osteoporosis, an age-related disease in which loss of bone mass causes skeletal deformities and fractures, affects nearly 20 million people in the US, mostly women. A major complication is a fracture of the thigh bone, in which case 20-30% of patients die in the year following the fract
...
Human Islet Amyloid Polypeptide transgenic mice
Introduction Amyloid deposits are found in the pancreatic islets of most individuals with non-insulindependent diabetes mellitus (NIDDM). The major component of islet amyloid is a 37-amino acid peptide, islet amyloid polypeptide (IAPP; amylin), which is a normal secretory product of the pancreatic β
...
Neuropeptide Y Y5 Receptor Knock-out mice
Introduction Neuropeptide Y (NPY), a 36-amino-acid neuromodulator abundantly expressed in the brain, has been implicated in the regulation of food intake and body weight. Pharmacological data suggest that NPY's stimulatory effect on appetite is transduced by the G-proteincoupled NPY Y5 receptor (Y5R
...
M1 Muscarinic Acetylcholine receptor Knockout Mice
Introduction Muscarinic acetylcholine receptors are members of the G protein-coupled receptor superfamily expressed in neurons, cardiomyocytes, smooth muscle, and a variety of epithelia. The M1 receptors are predominantly expressed in the CNS and are the most abundant muscarinic receptor subtype in
...
Dopamine Beta-Hydroxylase/Galanin Transgenic Mice
Introduction Galanin is a neuropeptide with multiple inhibitory actions on neurotransmission and memory. In Alzheimer's disease (AD), increased galanin-containing fibers hyperinnervate cholinergic neurons within the basal forebrain in association with a decline in cognition. Technology description D
...
Modular Adhesives and Energy-Dissipating Materials
BACKGROUND: Natural materials are renowned for their strength and toughness. Spider dragline silk has a breakage energy per unit weight two orders of magnitude greater than high tensile steel, and is representative of many other strong natural fibers. The abalone shell, a composite of calcium carbon
...
Searching Composition Space in Combinatorial Chemistry by Monte Carlo Methods
BACKGROUND: Combinatorial chemistry involves searching a large compositional space for compounds with a high figure of merit in order to find a molecule with a given property. However, current methods of searching only apply to relatively small libraries of compounds, with limited numbers of composi
...
Bifunctional Catalysts and Methods for Synthesis of Impermeable and Semipermeable Coatings
BACKGROUND: Fields that involve the handling of sensitive materials, such as electronics, chemicals, and biological agents need a means of safely isolating these items to protect them or the outside environment from contamination. Current methods for coating, sealing, or encapsulating these materia
...
Dact1 (Dpr1/Frodo1) Conditional Knockout Mice
Introduction Wnts are secreted signaling proteins important in development and disease in multicellular animals. These signaling proteins help regulate cell fate specification, cell morphology, cell proliferation, cell migration, cell polarity, tissue patterning, and therapeutic processes such as st
...
Use of microbes to extract and deliver metals from ores
Introduction Isolating a metal from its ore is traditionally performed via smelting, where the ore is chemically reduced under high temperatures. This process works most efficiently in cases such as copper, where there is a high concentration of the metal in its ore, However some metals, such as gol
...
Wheelchair with Support Seat
The wheelchair in this invention has a seat which pivots at the front and raises the user from the seated position to a near-standing or standing position and vice-versa. The power of the seat is from a spring which is put in tension when the user sits in the chair. When the user is in the seated po
...
BCRP expressing cell lines
Introduction The breast cancer resistance protein (BCRP) is an ATP-binding cassette efflux transporter originally identified by its ability to confer multidrug resistance in cancer cells. BCRP mediates the efflux transport of a broad spectrum of substrates, including many drugs routinely administere
...
Scn1A knockout mouse-a genetic animal model for human epilepsy
Introduction Epilepsy is one of the most common neurological disorders. Its pathophysiology is poorly understood and the available pharmacotherapies are effective only in a fraction of patients with frequent adverse side effects. Severe myoclonic epilepsy of infancy (SMEI), also known as the Dravet
...
CNS Tissue-selective Transgenic Animal Mouse Model
Introduction A central nervous system (CNS) specific knockout system has been unavailable thus far due to technical limitations. Recent advances have provided exciting data based on the use a liver-specific promoter to provide deletion of specific genes only in that tissue. This has successfully tra
...
Platelet Clotting Force Array
Introduction Advances in microfluidic technology are constantly opening doors to new and exciting applications, such as point-of-care diagnostic devices. These microscale diagnostic platforms will enable faster, cheaper, and more accurate patient evaluation for a wide array of parameters. One such p
...
KT Connector
aviation tool that solves the overheating problem on the Airbus. saves airlines on fuel costs. less fuel used is also better for environment . prevents delays and cancellations. improves on time performance and customer satisfaction.
...
Bicycle Storage Tree
We are looking to market our 8 unit, adjustable, and portable bicycle storage tree. Our projected retail price is $80-$100. We are looking for a licensing agreement or a sale of the patent. We are negotiable on terms. Contact Scott at 573-275-6443 if any interest in our product. Check the produc
...
Attachable Condiment Applicators and Kit Therefor
A kit comprising various devices for supplying condiments thereto foodstuffs and stored therein a case is herein disclosed. The kit incorporates interchangeable brushes similar to a basting brush that threadably engages a squeezable condiment bottle containing catsup, mustard, barbecue sauce, glazes
...
Instant Action Adjustable Wrench with Real Anti Slip Gripping System
This invention consists of following features:
a. Absolute Anti Slip Mechanism to protect from the damage of the work piece;
b. Instant Adjustment to Grip & Release by Thumb Pushing;
c. Simple structure for earsier manufacturing;
d. Less cost of production is required.
...
An optical spectroscopic approach for quantifying Hb/Mb ratio noninvasively in muscle tissue
Introduction Impaired blood flow and mitochondrial defects are involved in a wide variety of metabolic and degenerative diseases. The inability to quantify tissue hemoglobin (Hb) content presents a significant barrier to non-invasive assessment of regional mitochondrial function in blood flow. Techn
...
Non-toxic protocol to establish paraoxonase 1 (PON1) status
Introduction Paraoxonase 1 (PON1) is a member of a three-gene family localized on human chromosome 7. Due to its role in the metabolism of both lipids and organophosphorus
(OP) compounds, genetic variability in PON1 has been examined by many research groups as a risk factor for vascular and other d
...
Treatment of Microvascular Angiopathies
Introduction Acute injuries to smaller blood vessels and subsequent dysfunction of the tissue in which the injured blood vessels are located (microvascular angiopathies) are common features of a variety of diseases of different organs, such as kidney, heart and lungs. A subgroup of such diseases is
...
Methods of treating pulmonary disease using acetazolamide and structurally related derivatives
Introduction Alveolar hypoxia, as occurs with chronic lung diseases or ascent to high altitude, results in hypoxic pulmonary vasoconstriction (HPV). Exaggerated HPV causes high altitude pulmonary edema
(HAPE) and may complicate the course of patients with chronic cardiopulmonary disease. HPV is bel
...
Targeting Drugs to the Lymph Nodes for HIV and Cancer Therapies
Introduction HIV patients are currently treated using “HAART,” a highly active anti-retroviral therapy in which a plethora of drugs are administered to patients. This therapy is effective in reducing virus concentration in the blood, however, studies have shown that levels in the lymph nodes do not
...
Phospholipid Transfer Protein, a Regulator of Cholesterol
Introduction The level of cholesterol in the blood is an important risk factor for atherosclerosis and coronary artery disease (CAD) which can eventually lead to heart attack or stroke. Cholesterol is present in many forms, the most familiar of which are the lipoproteins LDL and HDL. As atherosclero
...
Warfarin Dosing and Genetic Variation
Introduction Warfarin is an anticoagulant used to prevent the blood from forming dangerous clots that could result in stroke. Determining the most effective and safest dose for each patient is extremely complicated and time consuming as warfarin metabolism varies greatly between patients and is affe
...
A Novel Diagnostic Test for Atherosclerosis and Clinically Active Coronary Artery Disease
Introduction Low levels of high density lipoprotein (HDL) are associated with a greatly increased risk of coronary artery disease (CAD). Evidence indicates that HDL protects against atherosclerosis by removing cholesterol from macrophages in the artery wall. In vitro studies indicate that chlorinati
...
A Microfluidic Device and Methodology for Rapid, Quantitative Determination of Analyte Concentration in a Fluid Sample
Introduction Advances in microfluidic technology are constantly opening doors to new and exciting applications, especially for biosensors and environmental monitoring. One recent area of interest is point-of-care diagnostic devices. These devices provide fast, accurate, and inexpensive sample analys
...
Transgenic Mice Expressing Human Myeloperoxidase
Introduction Myeloperoxidase (MPO) co-localizes with macrophages in the human artery wall, and its characteristic oxidation products have been detected in atherosclerotic lesions. Thus, oxidants produced by the enzyme might promote atherosclerosis. However, macrophages in mouse atherosclerotic tissu
...
Treatment of African Sleeping Sickness and Chagas Disease
Introduction African human trypanosomiasis is caused by the protozoan parasites Trypanosoma brucei which is transmitted through the bite of tsetse flies. Ultimately the trypanosomes cross the blood-brain barrier to invade the central nervous system causing often fatal neurological disorders. Current
...
Grasper Pad Sensing
Introduction Minimally invasive surgery is now being used routinely as one of the most preferred choices for various types of operations. Despite its many advantages, such as reduction of trauma, less pain, smaller injuries, faster recovery time, and reduction of postoperation complications, MIS dec
...
Use of the Type 3 Adenylyl Cyclase as a Drug Target Site to Treat Obesity
Introduction Obesity in the U.S. has increased dramatically in the past two decades. Although intensive efforts have been devoted to anti-obesity therapy, the percentage of obese individuals in the United States continues to increase. Because of this epidemic, there is considerable interest in molec
...
Methods and Compositions to Quantitate Thyroglobulin in Human Blood Specimens
Introduction Thyroglobulin is a marker of thyroid cancer. The presence of thyroglobulin in the plasma/serum of patients indicates functioning thyroid tissue. Following surgery and treatment with radioactive iodine, patients with thyroid cancer should be free of all functioning thyroid tissue. Detect
...
Mobile Antiseptic Spraying Tube (MAST)
Introduction Pneumatic tube systems are integrated within the walls and ceilings of many biomedical facilities and allow for the rapid transport of important materials, such as lab specimens and blood and tissue samples. In such a system, contamination due to biohazards must always be a concern, and
...
Construction and Use of Mutant Herpes Thymidine Kinase Genes in Cancer Therapy
Introduction In addition to surgery, many cancers are also treated with a combination of therapies involving cytotoxic chemotherapeutic drugs and/or radiation therapy. However, disadvantages to this method are that radiotherapeutic and chemotherapeutic agents are toxic to normal tissues, often have
...
Mouse Model of Gastrointestinal Stromal Tumor (GIST)
Introduction Recent developments have firmly established the important role of receptor tyrosine kinases in human cancer. Kit is a receptor tyrosine kinase and its role as a cellular oncogene has been established in a number of cancers including gastrointestinal stromal tumors (GISTs), which belong
...
Molecules and Methods for the Treatment and Detection of Cancer
Introduction Approximately 30,000 women are diagnosed with ovarian cancer yearly in the United States, and only about 50% of those diagnosed will survive the disease. Early, accurate prognosis of ovarian cancer is closely related to stage of the disease at diagnosis. It is estimated that about 106,0
...
Compositions and Methods for Detecting Pancreatic Cancer
Introduction Pancreatic cancer is a highly lethal disease; it is highly invasive and unresponsive to standard chemotherapy. The discovery of genes that cause familial forms of cancers has often shed light on the biology of the sporadic form of the disease. University of Washington researchers have i
...
Subversion of Bacterial Resistance by Low Solubility Antibiotic
BACKGROUND: Resistance to antibiotic treatment is increasingly common. Current strategies to overcome resistance include combination therapy with multiple classes of antibiotics, concurrent treatment with immunomodulating drugs or resistance inhibitors, or a mixture of these strategies. This inventi
...
Diagnosis and Treatment of Malignancy
Introduction Novel methods for the detection, monitoring, treatment, and prevention of malignancies have been developed that are based on the body’s own immune response to cell surface markers on cancer cells. Technology description Detection of the proliferation of T-cells in response to in vitro e
...
Tumor-cell Specific Adenoviral Vector Replication and Gene Expression
Introduction One of the greatest challenges in tumor gene therapy is to deliver an anti-tumor vector to every cell in the primary tumor and all distant metastases. This includes cells in the center of a tumor without direct contact to vasculature. First-generation adenovirus vectors are attractive f
...
Porphyromonas gingivalis LPS as an Immune Modulator
Introduction Vaccines often require the use of adjuvants, immune modulating substances, to generate adequate immune responses for the prevention or treatment of disease. Current adjuvant systems often display toxic properties, can be unstable, and can have unacceptably low immunostimulatory effects.
...
Safe and Potent Synthetic Lung Surfactant for Treating RDS and Acute Asthma
BACKGROUND: The use of lung surfactant dispersions, based on lipid and protein components extracted from animal lung tissue, has significantly reduced mortality and morbidity from respiratory distress syndrome (RDS) in premature infants in the past decade. However, existing lung surfactants are not
...
Methods for Identifying Novel Therapeutics and Diagnostics in the p53 Pathway
BACKGROUND: Current non-surgical cancer therapies rely on the use of compounds or radiation doses that are non-specific for the tumor cells and are highly toxic to humans. Although these treatments are particularly effective against tumor cells, they are also destructive to the surrounding normal ce
...
Novel Thymidylate Synthase Mutants for Treating Chemotherapy-induced Mucositis and Other Chemotherapy Side Effects
Introduction 35 novel thymidylate synthase (TS) mutants have been generated by random mutagenesis. These mutants are different from wild type TS in single, double, or multiple mutations, which are located distant from the active center. The new TS mutants reveal enhanced resistance to TS-inhibiting
...
Methods and Compositions for Diagnosing Hepatocellular Carcinoma
Introduction Currently, it is difficult to diagnose HCC. Methods employed generally rely on imaging techniques such as MRI, CT, and ultrasound and are of little use in detecting the disease in its earliest stages. As with most cancers, early detection of HCC would leave physicians with more treatmen
...
Improved use of Recombinant Viruses for Liver Regeneration
Introduction Diseases of the liver, both genetic and acquired, are especially detrimental due to the fact that the liver is a key organ for most metabolic pathways. Currently, the only method of curing liver diseases is via a liver transplant. Unfortunately, many transplants succumb to rejection, le
...
Ski Simulator
The invention relates to the field of sport, ski training simulators, particularly devices for exercises and slalom skills as well as devices for entertainment.
The foundation of the present invention is based on providing conditions for the full simulation of the skier’s movement on a real skiing
...
Surface Receptor Antigen Vaccines
Introduction The invention relates to DNA vaccines, or vaccines containing molecules encoded by such DNA, for the induction of specific, sustained high titer antibody responses. More specifically, the invention is directed to DNA vaccines that comprise recombinant expression constructs encoding a ce
...
Therapeutic Methods Based on Characterized BRCA1 and BRCA2 Proteins
Introduction Over a lifetime, it is estimated that women who have mutations in the BRCA1 gene or BRCA2 gene have up to a 55% and 25% risk of developing ovarian cancer, respectively. These rates are significantly higher than the 1.8% of women who are diagnosed with ovarian cancer without any inherite
...
Localization Wire for Surgical Excision of Breast Lesions
Introduction With the introduction of screening mammography, the median tumor size has decreased considerably, and approximately half of breast cancers in surgical practice are non palpable and amenable to breast conserving surgery. Traditionally, non palpable lesions are excised with a wire or wire
...
Novel Textures for Liquid-based Food Products
Highlights
Uses novel freeze-thawing processing technique to attain specific texture Answers continuing food industry need to provide desirable texture for food products manufactured from edible fluids Texturization method for dairy industry for yogurts, puddings, non-acid milk products, milk bev
...
The Multiple Drug Resistance Gene, Polymorphisms, and uses Thereof
Introduction Multiple drug resistance is a well-documented phenomenon and critical problem in the treatment of various diseases including cancer and HIV. While there are many mechanisms leading to multiple drug resistance, one area of focus is the MDR1 gene and its protein product P-glycoprotein (Pg
...
Commercial Auxin Substitute
A University of California researcher has identified a low-cost, non-toxic compound that can be exogenously applied to plants as foliar sprays to annual vegetable and perennial tree crops under commercial production to elicit an auxin response. Currently, various auxin derivatives are used for this
...
A Novel Therapeutic Strategy for HIV Infection
BACKGROUND: Tat is an HIV regulatory protein that is essential for viral replication and HIV disease progression. It critically regulates HIV transcription and allows the generation of full-length transcripts necessary for the formation of virus particles. Tat is also found in the circulation and ca
...
Expression and Purification of ATM Protein using Vaccinia Virus
BACKGROUND: Ataxia telangiectasia (AT) is a genetic recessive disorder involving a large range of symptoms including telangiectasia (dilation of blood vessels) on the eyes, face, and shoulders, ataxia (loss of balance), cerebellar degeneration, radiosensitivity, cancer predisposition, immunodeficie
...
Glucanase Regulation of Plant Growth and Development
Hydrolysis of the polysaccharides that compose plant cell walls is critical to cell expansion, and is therefore a key process in governing the growth and development of plants. Specifically, beta-glucan polymers form a ubiquitous matrix in plant cell walls, forming a molecular fabric around cells th
...
Anti-Pseudomonas Biofilm Agents
Introduction Pseudomonas aeruginosa infection is a serious problem in patients hospitalized with cancer, cystic fibrosis, and burns. This opportunistic pathogen causes infections that are difficult to treat by antibiotic therapy, due to its ability to organize as biofilms. Biofilms are groups of bac
...
Automated Yeast Pedigree Analysis
Introduction Saccharomyces cerevisiae, or budding yeast, is a single-cell eukaryotic microorganism that commonly is used by biologists to study genetics. Yeast pedigree analysis is used to study genomic instability associated with aging and cancer and involves the isolation and characterization of t
...
Fabrication of Gold Nanocages and Cubic Nanoframes for Biomedical Treatment through Etching Nanoboxes
Introduction Because of their small sizes and unique properties, nanomaterials are finding widespread use in studying complex biological systems. Gold nanostructures have been the subject of intensive research because of their unique and tunable surface plasmon resonance (SPR) properties. Because of
...
A Monoclonal Antibody Specific for Apolipoprotein A
Introduction Diagnosing the risk of developing heart disease is commonly done by measuring levels of cholesterol, HDLs, LDLs, and triglycerides. Lipoprotein A is an additional marker that is gaining support as being a determinant of heart disease. Thus, an ability to accurately detect and measure le
...
Oxidation Resistant form of Apolipoprotein A-I
Introduction High density lipoprotein (HDL) protects against atherosclerosis by removing cholesterol from cells of the artery wall. Apolipoprotein A-I (apoA-I), which accounts for ~70% of the total protein in HDL, promotes cholesterol and phospholipid efflux largely by an active transport process. T
...
Page: 1 - <10 - 15 16 17 18 19 20 21 - 10> - 118 Next»