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Global Qualitative Flow Path Modeling for Local State Determination (MSC-22618)

The technology supports reconfigurable models needed for analysis and simulation of industrial process automation where operations change the active flow paths in the system. The technology can be used to validate advanced process automation designs and software, where the active system structure ch
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Fuel Cell Housing for Rapid Start-Up Auxiliary Power and Gas Separation

APPLICATIONS: Assembling planar SOFCs into stacks for power generation Auxiliary power for autos and RV Individualized oxygen production for use in homes or hospitals ADVANTAGES: Start-up temperatures reached in 3.5 minutes for 400 thermal cycles without failure Survives the most extreme th
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High Quality, Dense Thin Films Using Metal/Metal Alloy Additives

APPLICATIONS OF TECHNOLOGY: Solid oxide fuel cells Gas separation Mixed ionic electronic thin film devices Sensors Magnetic films Various barrier coatings Potentially LaCrO3 interconnects ADVANTAGES: Produces high quality, gas-tight, dense films in a single step Net zero volume change in f
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Solid Oxide Fuel Cell Technologies: Improved Electrode-Electrode Structures for Solid State Electrochemical Devices

APPLICATIONS OF TECHNOLOGY: Gas separation Fuel cells Catalytic reactors Other devices ADVANTAGES: Improved performance Improved reliability ABSTRACT: Berkeley Lab researchers Lutgard DeJonghe, Steven Visco, and Craig Jacobson have focused their attention on solid oxide fuel cells (SO
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Improved Segment-in-Series High Temperature Electrochemical Device

APPLICATIONS OF TECHNOLOGY: Solid oxide fuel cells Oxygen generators Electrolyzers ADVANTAGES: Greatly expands the choice of sealing materials Promises inexpensive manufacturing, high sealing quality, and long lifetime Applicable to devices of any geometry, including planar and tubular Allo
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Inexpensive Production of High Density Thin Ceramic Films on Rigid or Porous Substrates

APPLICATIONS OF TECHNOLOGY: Solid oxide fuel cells Electrochemical devices Protective barrier coatings Gas separation membranes Membrane reactors Sensors ADVANTAGES: Achieves thicknesses between 1 mm and 100 mm without cracking Less expensive than vapor or plasma techniques Films are fully
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Low Cost Fabrication of Thin-Film Ceramic Membranes for Nonshrinking Substrates

APPLICATIONS OF TECHNOLOGY: Tubular solid oxide fuel cells Ceramic membrane fabrication Electrolytic separation ADVANTAGES: Produces high quality films on non-shrinking substrates Scalable for low cost industrial production Minimum number of processing steps Enables sintering at lower temp
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Low-Cost Layered Structure for High Temperature Electrochemical Devices

APPLICATIONS OF TECHNOLOGY: Solid oxide fuel cells Oxygen generators Electrochemical reactors ADVANTAGES: Offers less expensive manufacturing Displays excellent mechanical bonding between layers and a robust structure Expands the choice of electrode catalysts Applies to planar or tubular ce
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Metal Current Collector Protected by Oxide Film

ADVANTAGES: Inexpensive Structurally sound APPLICATIONS OF TECHNOLOGY: Electricity production (e.g. solid oxide fuel cells) Electrolytic gas separation Electrolytic syngas production by partial oxidation ABSTRACT: Steven Visco, Craig Jacobson, and Lutgard DeJonghe have designed a co
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Method for Making Flat, High Performance Thin Membrane Structures on Porous Substances

APPLICATIONS OF TECHNOLOGY: Planar solid oxide fuel cells Planar gas separation devices Planar membrane reactors ADVANTAGES: Produces high-quality thin films with no warping or cracking Solid oxide fuel cells fabricated with this method show exceptional performance at reduced temperatures
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Novel Support Structure for Ceramic Electrochemical Devices

APPLICATIONS OF TECHNOLOGY: Gas separation Fuel cells Catalytic reactors Energy generation Coal gasification Selective oxidation of hydrocarbons ADVANTAGES: Economical Increased reliability ABSTRACT: Berkeley Lab researchers Lutgard DeJonghe, Steven Visco, and Craig Jacobson have
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Capacitance Probe for Fluid Flow and Volume Measurements (MSC-22544)

The technology replaces mechanical flowmeters used currently with a simple, dependable electronic device with no moving parts. It is more accurate and not as invasive. Its readings are instantly converted from analog signals to digital records. These records could be broadcast on any bandwidth neede
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Capillary Pumped Loop Body Warmer (GSC-13329)

Capillary Pumped Loops (CPL) are a space-age technology for thermal control. GSFC uses CPLs for spacecraft thermal control and recently developed a concept for application of CPLs to human body thermal regulation. The key advantage is that CPLs can operate without an external mechanical pump to redi
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NASA Smart Materials and Structures

The Morphing Project seeks to integrate smart, biologically inspired, or other unconventional approaches to lead to aggressive improvements in the efficiency, versatility and safety of future air and spacecraft. The foundation of this multi-disciplinary project is research on smart materials and the
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CCD System Technology for Extremely Low Background Observations (GSC-13906)

Charge-coupled devices have proven to be exceptionally versatile and effective detectors for imaging wavelengths between the near-ultraviolet and the near-infrared portions of the spectrum. Although detector format/size and sensitivity have increased to meet demand, these larger detectors have techn
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High Rate Parallel Digital Receiver (NPO-21230)

The data rates for NASA missions are increasing very rapidly. In order to process these high data rates, high-processing hardware is required. For baseband data processing, there exist inexpensive PCI-based solutions; But for RF processing, the current solutions are based on either all analog or mix
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Proton-Transfer-Reaction/Ion-Mobility-Spectrometer (PTR-IMS) (NPO-21187)

A small, portable detector with high sensitivity suitable for detection of trace amounts of organic compounds, PTR-IMS does not suffer from problems associated with commonly used gas chromatography/mass spectrometry-based instruments (GC/MS) such as limited sensitivity, fragmentation of large organi
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Parallel Subconvolution Filter Architectures (NPO-30142)

The goal was to develop simple architectures to implement in parallel/vector processing form to reduce the processing rate required by the hardware and able to be extended to any length filter desired, with only linear increase in complexity. The improvement of these novel architectures is that they
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Control System for Prosthetic Devices (MSC-21941)

Although many prosthetic devices have been developed, including computer controlled "bionic" or hydraulically actuated devices, these devices do not provide user feedback. Additionally, below-the-elbow amputees favor some derivation of the traditional hook-and-cable harness system developed in th
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Discrete Event Simulation Tool for Analysis of Qualitative Models of Continuous Processing Systems (CONFIG) (MSC-21465)

CONFIG is a general-purpose simulation tool that can support simulations in several domains, including process-oriented industries (chemicals, foods, pharmaceuticals), water and waste processing, manufacturing, power systems, and computer/telecommunication networks. CONFIG is an enhancement of discr
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Electroplating of Hard Glassy Metals (MFS-31377)

Although it yields a high quality coating, electroless deposition does not allow for much process control, requires high processing temperatures, and has a slower deposition rate than with electroplating. Better process control is available through electroplating, which involves placing a voltage ac
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3-D Roller Locking Sprags (GSC-13617)

Many machines with rotating parts use brakes and clutches to stop or control the degree and direction of motion of the driven parts. Brakes and clutches often are incorporated between concentric races (i.e., rotating shafts). One class of locking brake/clutch uses spherical balls or cylindrical roll
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Emulsified Zero-Valent Iron (EZVI) (KSC-12246)

Emulsified Zero-Valent Iron is a versatile technology that can be used at many of these locations. Applicable sites may include: dye and paint manufacturers;dry cleaners; chemical manufacturers; metal cleaning and degreasing facilities; leather-tanning facilities; pharmaceutical manufacturers; adhes
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Phone for Blinds and Illiterates

Phone for Blinds and Illiterates’, a patent pending technology, provides a convenient method for dialing ,programming and storing telephone numbers equally beneficial for a common, illiterate, aged, visually handicapped and physically challenged person.
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Data processing system and microprocessor for it.

This invention relates to the field of computer hardware and namely to various architectures of universal multiprocessor systems. The high-efficiency data of the data processing system of this invention is achieved by the following: each data processing device of this system has several address
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Thermal Profiling of Nanoscale Circuitry

APPLICATIONS OF TECHNOLOGY: Thermal management of small devices and systems, whether semiconductor electronics, nanofluidics, or photovoltaics Design, prototyping and characterization of new circuit models High-resolution measurement at extreme temperatures ADVANTAGES: Does not interfere wi
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Transmission Electron Microscope Phase-contrast Enhancement

APPLICATIONS OF TECHNOLOGY: High-contrast electron microscopy, especially for radiation-sensitive materials and weak phase objects like: whole-mount subcellular organelles and thin areas of whole cells isolated biological macromolecules thin crystals thin sections of cells and tissues Single-par
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Synthetic Nano-Low Density Lipoprotein As a Targeted Drug Delivery Vehicle

Drug delivery to tumors with increased LDL-cholesterol requirements and LDL receptor activity, including: brain, colon, prostrate, liver, lung, adrenal, hormone unresponsive breast, leukemia ADVANTAGES: Targets the LDL receptor for selective drug delivery and entry into the lysosome Contains m
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Large Scale Controlled Placement of Nanoparticles and Nanostructure

APPLICATIONS OF TECHNOLOGY: Manufacturing MEMS and NEMS devices, e.g. arrays, solar collectors, nanoscale memory and optical switching devices, field emitters, chemical or mass sensors, LEDs, flexible interconnects, mechanical filters, microfluidic pumps and gates ADVANTAGES: Allows precis
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Large Scale Controlled Placement of Nanoparticles and Nanostructure

APPLICATIONS OF TECHNOLOGY: Manufacturing MEMS and NEMS devices, e.g. arrays, solar collectors, nanoscale memory and optical switching devices, field emitters, chemical or mass sensors, LEDs, flexible interconnects, mechanical filters, microfluidic pumps and gates ADVANTAGES: Allows precis
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Defect Elimination in Nanoscale Materials

APPLICATIONS OF TECHNOLOGY: Generating defect-free nanotubes or nanowires with superior mechanical, thermal, and electrical properties for devices such as MEMS/NEMS, ICs, and resistors, as well as for ultimate-strength materials Creating sophisticated heterojunctions in a MWNT by refining specifi
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Nanoknife: the Precision Cutting of Molecular-scale Materials

APPLICATIONS OF TECHNOLOGY: Precise cutting and tailoring of small scale structures and devices Tailoring nanostructures/nanomaterials to create field emitters, quantum dots, nanoscale resonators, electrical interconnects and circuitry, linear and rotational bearings, NEM/MEMS components, sca
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Fabrication of Uniform and Spatially Controlled Nanostructures on Substrates

APPLICATIONS OF TECHNOLOGY: Ultra-sensitive biological and chemical sensing Microchips Catalysis Nanocomputing and nanoelectronics ADVANTAGES: Uses standard semiconductor fabrication equipment and techniques to produce nanosize semiconductors on a wafer scale Produces smaller feature siz
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Protease-based Cancer Screening

APPLICATIONS OF TECHNOLOGY: Early stage screening of cancers via detection of proteases and proteolytic activity in fluid or biopsy samples Prostate cancer detection, and possibly the detection of other protease-related cancers such as breast, colon, kidney, skin, stomach, ovary, and lung cancer
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Predictive Methodology and Tools for Nanotoxicology

APPLICATIONS: High throughput and high content nanotoxicity screening Discovering new nanotoxicology profiles and new targets for nanotherapy Nanomaterial toxigenomics and high content imaging analysis ADVANTAGES : Minimizes the need for expensive and controversial animal studies Enables ra
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Non-contact Nanoscale Imaging of Liquids and Weakly Bound Material

APPLICATIONS OF TECHNOLOGY: Detection of contamination in semiconductor processing Detection of liquid films affecting wetting and adhesion on surfaces Imaging of liquids interacting with organic material in biological systems Characterization of biomaterials: o Hydrophilic and hydrophobic r
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Nanomachining of High Aspect Ratio Structures

PPLICATIONS OF TECHNOLOGY: Micromachining of sensors, detectors and actuators Quantum devices Heat sinks High aspect ratio lithography Medically implanted and surgical devices and sensors Non-destructive microcircuit inspection Packaging and integration of miniaturized components ADVANTAGES:
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Method for preparing less-immunogenic protein-lipid complexes

A novel method has been developed for preparing less immunogenic protein formulations. One composition derived from this method has demonstrated promising results in the delivery and efficacy of protein therapeutics (Factor VIII) involved in hemophi lia. By shielding the most immunogenic portion of
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Zero Bias Switch

ZBS (Zero Bias Switch) patent # 7,106,188 A long range radio receiver without an amplifier (no battery drain) This RF receiver is acitvated by the incoming signal no stand-by power is needed. Make new hybrdid RFID tags that need no battery replacements and much more
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A vaccine to prevent infection by nontypeable Haemophilus influenzae infection

Currently, there is no effective vaccine to prevent infection by non-typeable Haemophilus influenzae (NTHi), a leading cause of otitis media as well as a number of other upper respiratory tract infections that affect both pediatric and adult populati ons. The most common treatment for OM is antibiot
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C-Pap Face Protector

A comfortable, moisture absorbant barrier between the face and the plastic of the c-pap mask. Helps to eliminate discomfort of sweating around the nose & mouth as well as helping to control skin problems due to that sweating.
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Confocal Microscope with 2-D Array of LEDs

Background Confocal microscopes can provide 3-dimensional (3D) images with superior contrast and depth resolution compared to conventional wide-field microscopy because they reject the out-of-focus light. This makes them the tool of choice for advanced laboratory imaging, e.g. for life sciences or
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CYP2D6 and CYP3A4 double transgenic mice

Human CYP2D6 and CYP3A4 collectively metabolize over 70% of drugs on the market. In an effort To study the developmental and sexual expression and regulation of these two major human drug-metabolizing P450s, a double transgenic mouse line carrying b oth CYP2D6 and CYP3A4 transgenes (Tg-CYP2D6/CYP3A4
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Design of Energy Harvestor Based on Piezo-shape Memory Alloy Composites

Introduction Shape memory alloy (SMA) materials act as an energy harvestor in locations where temperature fluctuates between high and low readings (e.g. 0C – 150C for TiNi SMA). Stress change in the piezo-phase generates a voltage change and electrical power. Technology description Researchers at th
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Development of Large Bandgap Host Materials for Phosphorescent Emitters

Introduction The performance of organic light-emitting diodes (OLEDs) has improved dramatically over the past decades. However, the efficiencies of conjugated polymer-based phosphorescence devices usually are much lower than those of small-molecule based devices. Although external efficiencies of gr
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Position-Specific Insertion Vectors and Method of Using Same

Background: Retrovirus vectors infect cells at high efficiency and are capable of integrating DNA copies of themselves into a host genome. Such vectors are, in many ways, desirable for introduction and expression of exogenous DNA sequences in animal cells. In gene therapy or in the production of tr
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Assay for and Treatment of Autoimmune Disease

The invention is directed to prognosis, diagnosis and treatment of autoimmune diseases, including SLE (systemic lupus erythematosus), type-1 diabetes, experimental allergic encephalomyelitis (EAE) and other, which demonstrate uniquely the presence abnormal double-negative (CD4- and CD8-) T cells exp
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Cash-My-Check

Cash-My-Check (CMC) is a self service check cashing machine that provides real-time check verification for payroll, personal and corporate checks. The Cash-My-Check (CMC) combines form and functionality to provide the best check cashing experience in the retail market today. With a variety of per
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Petrol Saving Device

This device is based on the patent filed for the method of stabilizing the turbulence created by valves in a flow system (patent pending). Based on the technology we fix this device through pneumatic tubes before and after the throttle valve (carburetor) in a petrol vehicle,which controls the turbu
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Method of identifying and registering entities and an assembly of hardware and software for applying such a method

This is a methode for implementation of identification code systems in a DNS (Domain Name System) providing domains + web pages, and services to clients. Practically this means that all kind of identification code (like telephone numbers isbn or social sec. nr) systems exclusively can be implemented
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Lineographic Alphanumeric Data Input System

This input system is designed for entering text into portable electronic devices, such as cell phones, hand held computers and intelligent phones, by making short linear traces or taps with a finger or thumb on a touch sensitive keypad. The system allows the user to enter operational commands on th
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Absorption system of shock waves and armor for military vehicles

Absorption system of shock waves and armor for military vehicles System absorption of shock waves for armored military vehicles and construction consisting of the body and interior of the vehicle by a structure pre hollow interior frameworks available boxes (Fig. 1) with a considerable thickness a
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Device for Organizing the Administration of Pills At Predetermined Time Intervals

A device for organizing the administration of pills at predetermined time intervals, characterized in that it has a main body used as an individual tissue ring with an opening, through which tissues can be inserted, and that the main body includes at least one compartment (4,4',4''), which can hold
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Method of Inhibiting the Transport of L-glutamate

Background: L-Glutamate is one of the most abundant excitatory neurotransmitters in the mammalian brain and, as such, is responsible for many synaptic transmissions in the central nervous system. Yet, while other neurotransmitters are degraded rapidly to terminate the transmitter signal, L-glutamat
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Isolation of Biological Materials

Currently, flow cytometry is the only method available for the purification of specific chromosomes. The current flow cytometry method requires a long time to sort large quantities of cellular starting material for a single chromosome. Furthermore, species with similarly sized chromosomes, such
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Data Compression of Time-Varying Images

Background: Current methods of transmitting time-varying images involve encoding the digital image information into a set of still frames. To reduce the bandwidth necessary to transmit the full image, compression techniques are used to eliminate statistically redundant information in the pixel inte
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Drugs to Improve Synaptic Transmission

About 5% of the general population over the age of 65 suffers from Alzheimer's disease for which there is no known treatment. Synaptic connections in the hippocampus, a brain region known to be important for learning and memory are especially vulnerable to Alzheimer's disease. This presumably reflec
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Transgenic Animal Models for Alzheimer's Disease

The present invention provides non-human, transgenic animals for use as a model for the study of Alzheimer's Disease. The animals exhibit pathology associated with Alzheimer's Disease. The phenotype is conferred in the animals by the introduction of an amyloid-containing polypeptide fragment of amyl
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Method for Distributed Redundant Execution of Program Modules

Background: Several schemes have been implemented in distributed computer systems which recover execution of program modules when hardware and software failures occur. The distributed recovery block scheme executes a primary and backup copy of a program on multiple processors. The processors commun
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Novel Device for Determining the Viability of Human Myocardium Or Other Animal Tissues

Background: The last decade of cardiac surgery has witnessed significant strides towards better understanding and better management of previously lethal cardiac pathology. Such developments have led to a general recognition of previously unknown conditions such as myocardial stunning and hibernatio
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Tissue Viability Monitor

Background: The last decade of cardiac surgery has witnessed significant strides towards better understanding and better management of previously lethal cardiac pathology. Such developments have led to a general recognition of previously unknown conditions such as myocardial stunning and hibernatio
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Voltage-Gated Potassium Channel Gene, Kv1.7, Vectors and Host Cells Comprising the Same, and Recombinant Methods Of…

It has long been believed that the secretion of insulin from pancreatic beta cells in the Islets of Langerhans is induced by the presence of glucose at the outer surface of the beta cell membrane. This secretion is regulated through a series of processes at the surface of the cell which allow the in
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A New Polymerization Method for Polymethylene

Background: The most common method for manufacturing polyolefins and their derivatives is by polymerization of olefin monomers with Ziegler-Natta catalysts or by the use of free radical, nucleophilic, or electrophilic initiators. Although one can achieve high molecular weights with these methods, t
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A Novel Method for Eliminating Mach Waves in Supersonic Jets

Aircraft designers face the technological challenge of reducing the noise produced by supersonic aircraft exhausts. These exhausts, if left untreated, produce environmentally unacceptable levels of noise. Much of this noise is due to Mach waves, the shock waves attached to turbulent eddies moving at
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Method of Eliminating Mach Waves from Supersonic Jets

Background: Community noise is one of the major technological challenges faced by designers of future supersonic transports, such as the High-Speed Civil Transport (HSCT). The hot supersonic jets exhausting from the engines of such aircraft are powerful noise generators, especially during take-off.
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One Cycle Control of Bipolar Switching Power Amplifiers

Researchers at the Power Electronics Laboratory at University of California, Irvine, received a U.S. patent for a device that uses one cycle control for controlling DC-to-AC switching converters. This is achieved by forcing the average of a controlled switched variable to be exactly equal to the con
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A Method and Apparatus for Use in Antifibrotic Therapy of Ophthalmic Filtration Surgery

A Method And Apparatus For Use In Antifibrotic Therapy Of Ophthalmic Filtration Surgery
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Humidity and Temperature Sensor Device for the Determination of Oxygen Consumption in Medical Applications

Background: The determination of oxygen consumption is an important monitor of normal cardiopulmonary and tissue function in anesthesia and critical care medicine. This requires accurate measurement of inhaled and exhaled volumes. Traditionally, it has been very difficult to measure the extra volum
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Aluminum - Lithium Alloy Metal Matrix Composites

For high temperature aerospace application, Ti alloys are often utilized to produce structural parts. However, the cost has often been the drawback. Finding an alternative has motivated the development of advanced aluminum alloys to satisfy the requirement of titanium alloys. Researchers of the Univ
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Phototherapeutic Inactivation of Ocular Viruses

A variety of diseases could be significantly controlled using this new treatment for viral ocular infections in humans, including cytomegalovirus (CMV) retinitis in AIDS patients, herpes keratitis, and viral conjunctivitis. CMV retinitis is the most common ocular opportunistic infection and the lead
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Enhancement of Host Defense Via Receptor(s) for C1q

Background: As the development of protein products and peptide mimetics becomes more prevalent in the biotechnology and pharmaceutical industries, the ability to mimic the protective and modulate the inflammatory effects of the recognition protein of the classical complement cascade in blood and bo
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A General Constant Frequency Pulse-Width Modulator and Its Applications

Background: Switching converters are commonly used to provide DC to DC, DC to AC, AC to DC, and AC to AC conversion of electrical waveforms. These converters are often categorized by applicable circuit configuration and/or capabilities, and include buck converters (where the load voltage is less th
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Brain Aging Assay

Researchers at the University of California, Irvine, have created a model of brain aging in cultured brain slices. These slices provide an in vitro model for the following: 1) the study of brain aging; 2) an assay for anti-brain aging drugs; and 3) therapeutics directed at the clinical condition ref
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Mixing Enhancement Using Propulsive Means

A novel mixing enhancement method exploits a previously unknown flow instability to enhance mixing in a compressible jet flow or in a flow (gaseous of liquid) in contact with the compressible jet flow. No mechanical mixers and no actuators of any kind are used. Nozzle shapes are streamlined and simp
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Prevention of Ice Formation on Tissue Surfaces Caused By Cooling During Laser Surgery

Background: A complication of using a cryogen gas to provide cooling during laser irradiation of biological tissues is the formation of ice crystals. This formation of ice on the tissue surface causes two major problems: 1) it decreases the incident light dosage due to optical scattering by the cry
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Diagnostic Marker and Novel Therapeutic Target for Neurodegenerative Disorders

Scientists at the University of California, Irvine, have isolated a candidate gene that may be responsible for increasing the risk of schizophrenia and bipolar disorder. This elusive gene encodes for a potassium ion channel that acts like an "off switch" by dampening electrical activity in neurons.
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Novel and Selective Inhibitors of HIV-1 Integrase

In the ongoing battle against the human immunodeficiency virus (HIV), researchers at the University of California, Irvine, have synthesized novel compounds that inhibit the protein HIV Integrase and prevent the virus from replicating, thus providing an alternative to currently available AIDS therapy
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Modulation of Cell Growth and Growth Factor Signaling Through Removal of Glypicans

Background: Membrane associated heparin sulfate proteoglycans (HSPGs) have been shown to play important roles in many aspects of cell behavior, including cell-cell and cell-extracellular matrix adhesion and growth factor signaling. Glypicans, members of the HSPGs, are a family of polypeptides that
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Treatment for Circadian Performance Deficits By Upmodulation of Central Glutamate Receptors

Background: Alertness and general physical and mental performance are impaired during normal sleep periods compared to those during normal waking periods. Unlike stimulants such as caffeine or methamphetamine, certain glutamatergic enhancer compounds have been shown to improve memory and performace
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Use of Perillyl Alcohol in Organ Transplantation

Background: Current state of the art in the field of organ transplantation employs various immunosuppressive agents to prevent post-surgical allograft rejection by the host. However, these pharmacological agents often result in many adverse side effects due to the quantities of medication that are
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Donor Organ Preservation for Transplantation Using a Hemoglobin Based Solution

During heart transplantation, the heart must be preserved while it is transported from donor to recipient. Standard techniques call for the heart to be immersed and cooled in cardioplegia or saline solution. Unfortunately, this method does not deliver necessary oxygen, nutrients, and electrolytes to
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Use of Infectious and Pathogenic Clone of a Lung Cancer-Inducing Retrovirus for Generation of Therapeutic Reagents and Diagnostic Tests

Background: Jaagsiekte sheep retrovirus (JSRV) causes broncheolo-alveolar carcinoma in sheep and is a significant veterinary problem world-wide. Clinically and histopathologically, this disease has strong resemblance to broncheolo-alveolar carcinoma (BAC) in humans which accounts for approximately
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A New Process of Adding Alkyl Groups to Organic Substrates Using TmI2(MeOCH2CH2OMe)3

Background: In the pharmaceutical industry, synthetic chemists often alkylate starting compounds to generate compounds that have more desirable properties. However, the current reagents used in this modification process can be expensive or harmful to the chemist. Technology: Researchers at the U
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A Novel Treatment for Upper Respiratory Tract Irritation and Cough

Background: Traditional cough suppression therapy has included palliatives in the form of herbal remedies, narcotics such as codeine, and local anesthetics such as benzonatate. The anesthetic compounds have limited efficacy, while the narcotics cause severe side effects because they work through th
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Protocol and Software Organization Method for Real-Time Fault-Tolerant Multicasts in Computer Networks

Background: Components of application systems based on a network of computing nodes (e.g., PC's and workstations) often maintain the client-server relationship among themselves. For the sake of attaining high system reliability and performance, servers are often replicated. These servers must then
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Corneal Transplantation

Background: Corneal damage due to accident or disease results in varying degrees of blindness in millions of individuals throughout the planet. In some cases it is possible to restore vision by a corneal transplant. A full-thickness transplant (penetrating keratoplasty, PK) runs a high risk of graf
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High Speed Circuit Board Writing

A method of printing lines on circuit boards from computer information in a manner similar to using an inkjet printer. Utilizing capillary stream break-up of molten metal droplets, this novel approach is capable of printing very fine lines on the order of 10 microns wide and many centimeters long at
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High Speed Fabrication of Highly Uniform Metallic Spheres

An inexpensive method of generating highly uniform metallic balls from capillary stream break-up at ultra high speeds. Manufacture of solder balls (and other metallic balls), commonly used in the electronics industry, can be achieved using this method. Due to the nature of the droplet formation from
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Treatment for Prostate Cancer

Background: Polyamines are naturally synthesized by the body and are involved in many biochemical processes, including cellular proliferation, cell cycle regulation, and protein synthesis. The prostate epithelium synthesizes plyamines at a high rate making the prostate gland having one of the highe
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Molecular Imprinting for the Recognition of Peptides in Aqueous Solution

Molecular imprinting is a process for synthesizing materials that contain highly specific recognition sites for smaller molecules. Today, molecular imprinting is used for many purposes, including the creation of macromolecular binding and catalytic sites and as binding sites for the separation or re
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ADP Glucose Receptor as a Target for Disorders Involving Platelet Aggregation

Background: Recently, activation of the P2Y12 G-protein coupled receptor (GPCRs) has been shown to be central to platelet aggregation. Drugs preventing platelet aggregation are being tested, but one that would be specific to the P2Y12 receptor would capture a large market share. Developing drugs fo
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Platelet Aggregation Inhibitors

Thrombin is an enzyme in the blood that plays a key role in platelet formation during injury. While blood coagulation is essential for a surface wound, platelet activation underlies various pathological situations such as unstable angina pectoris, myocardial infarction and stroke. Thrombin is mediat
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Wnt, Fz, and BMP-6 Receptors for the Treatment and Detection of Colon Cancer

Background: Ectopic activation of the Wnt signaling pathway leads to increased cellular growth and division in experimental organisms and mutations in the Wnt pathway. Wnt pathway genes are tightly linked to the genesis of certain cancers in humans, such as colon cancer. Technology: University o
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Her2/neu Vaccine Protects Against Tumor Growth

Background: Her2/neu is over-expressed in various types of tumor cells, including 20-30% of breast cancers, adenocarcinomas of the ovary, salivary gland, stomach and kidney, colon cancer, and non-small cell lung cancer. Passive immunotherapeutics like Herceptin control and prevent further tumor cel
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DRD4, ADHD

Background: Attention Deficit Hyperactivity Disorder (ADHD) is the most prevalent disorder of early childhood. It affects an estimated 3-6% of elementary school children. ADHD individuals may have abnormal release of dopamine resulting in a "dopamine deficit" that leads to cognitive as well as beha
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Gyrotropic Phontonic Crystals and their Applications in Microwave Technology

By proper spatial arrangement of magnetic and dielectric components, one can construct a magnetic photonic crystal with strong spectral asymmetry (nonreciprocity). The spatial asymmetry, in turn, results in a number of interesting phenomena, in particular, one-way transparency when the magnetic phot
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Novel Retinoblastoma Binding Protein-Related Gene and Potential Use As Cancer Vaccine

Background: The central objective in the development of an effective immunotherapy is the identification of tumor antigens that can elicit antibody and cellular immune responses in humans. Human autologous or allogeneic antibodies from cancer patients are an alternative to the use of monoclonal ant
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Smart Probe with Station for Real Time, Non-Invasive Metrology of Microfluidic Chips

A smart computer controlled bio-microfluidic probe station, which facilitates real-time non-invasive measurements of quantitative, cross sectional information of biological fluid flow at various locations within a bio-fluidic chip. This station would allow for automated, high-throughput testing and
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Screening and Therapeutic Methods for Promoting Wakefulness and Sleep

Background: Current drugs used to modulate sleep and wakefulness cause a number of undesirable side-effects such as anxiety, addiction, and continued sedation. AMPA and PrRP receptors are found in the reticular thalamic nuclear (RTN) region of the brain that has been implicated in sleep rhythms, at
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Miniature Liquid-Fueled Combustion Chamber

Background: Several challenges exist with the development of miniature combustors (sometimes named micro-combustors). The large surface-to-volume ratio can result in substantial heat losses causing inefficiency at the least and flame quenching at the worst. The low residence times causes difficulty
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