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Molecular Imprinting for the Recognition of Peptides in Aqueous Solution

Molecular imprinting is a process for synthesizing materials that contain highly specific recognition sites for smaller molecules. Today, molecular imprinting is used for many purposes, including the creation of macromolecular binding and catalytic sites and as binding sites for the separation or re
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ADP Glucose Receptor as a Target for Disorders Involving Platelet Aggregation

Background: Recently, activation of the P2Y12 G-protein coupled receptor (GPCRs) has been shown to be central to platelet aggregation. Drugs preventing platelet aggregation are being tested, but one that would be specific to the P2Y12 receptor would capture a large market share. Developing drugs fo
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Platelet Aggregation Inhibitors

Thrombin is an enzyme in the blood that plays a key role in platelet formation during injury. While blood coagulation is essential for a surface wound, platelet activation underlies various pathological situations such as unstable angina pectoris, myocardial infarction and stroke. Thrombin is mediat
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Wnt, Fz, and BMP-6 Receptors for the Treatment and Detection of Colon Cancer

Background: Ectopic activation of the Wnt signaling pathway leads to increased cellular growth and division in experimental organisms and mutations in the Wnt pathway. Wnt pathway genes are tightly linked to the genesis of certain cancers in humans, such as colon cancer. Technology: University o
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Her2/neu Vaccine Protects Against Tumor Growth

Background: Her2/neu is over-expressed in various types of tumor cells, including 20-30% of breast cancers, adenocarcinomas of the ovary, salivary gland, stomach and kidney, colon cancer, and non-small cell lung cancer. Passive immunotherapeutics like Herceptin control and prevent further tumor cel
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DRD4, ADHD

Background: Attention Deficit Hyperactivity Disorder (ADHD) is the most prevalent disorder of early childhood. It affects an estimated 3-6% of elementary school children. ADHD individuals may have abnormal release of dopamine resulting in a "dopamine deficit" that leads to cognitive as well as beha
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Gyrotropic Phontonic Crystals and their Applications in Microwave Technology

By proper spatial arrangement of magnetic and dielectric components, one can construct a magnetic photonic crystal with strong spectral asymmetry (nonreciprocity). The spatial asymmetry, in turn, results in a number of interesting phenomena, in particular, one-way transparency when the magnetic phot
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Novel Retinoblastoma Binding Protein-Related Gene and Potential Use As Cancer Vaccine

Background: The central objective in the development of an effective immunotherapy is the identification of tumor antigens that can elicit antibody and cellular immune responses in humans. Human autologous or allogeneic antibodies from cancer patients are an alternative to the use of monoclonal ant
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Smart Probe with Station for Real Time, Non-Invasive Metrology of Microfluidic Chips

A smart computer controlled bio-microfluidic probe station, which facilitates real-time non-invasive measurements of quantitative, cross sectional information of biological fluid flow at various locations within a bio-fluidic chip. This station would allow for automated, high-throughput testing and
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Screening and Therapeutic Methods for Promoting Wakefulness and Sleep

Background: Current drugs used to modulate sleep and wakefulness cause a number of undesirable side-effects such as anxiety, addiction, and continued sedation. AMPA and PrRP receptors are found in the reticular thalamic nuclear (RTN) region of the brain that has been implicated in sleep rhythms, at
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Miniature Liquid-Fueled Combustion Chamber

Background: Several challenges exist with the development of miniature combustors (sometimes named micro-combustors). The large surface-to-volume ratio can result in substantial heat losses causing inefficiency at the least and flame quenching at the worst. The low residence times causes difficulty
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Method and Apparatus for Tissue Reshaping by Radio Frequency Heating

Background: The functional and esthetic defects in the head and neck that result from surgery, trauma, or congenital malformations have led to the development of surgical techniques to reshape cartilage. Conventional reconstructive techniques (e.g., otoplasty, rhinoplasty, tracheoplasty) involve th
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Novel Cytodiagnostic Markers for Cancer

Background: Cervical cancer is one of the leading causes of cancer-related death in women worldwide. Approximately 500,000 new cases are diagnosed each year and pre-cancerous abnormalities of the cervix occur in far greater numbers of women each year. Cervical carcinomas develop progressively from
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Robotic Hip Swinger

Background: Over 700,000 people in the U.S alone suffer strokes each year often resulting in an impairment of walking ability. A popular approach to locomotion rehabilitation called body weight supported (BWS) training shows promise in improving locomotion after strokes. However the technique invol
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hKCa3/KCNN3 Calcium Activated Potassium Channel: a Diagnostic Marker and Therapeutic Target for Heritable, Neurological and Psychiatric Diseases

University of California, Irvine researchers have discovered SKCa3-1b and SKCa3-1c, two novel isoform variants of the SK3 (also known as KCNN3) gene. The SK3 gene is located on human chromosome 1q21 in a region containing a major susceptibility locus for familial schizophrenia and familial hemiplegi
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Differential Diagnosis of Oral Pathologies

Background: A wide range of oral pathologies have very similar or identical clinical appearance, such as leukoplakia or erythroplakia. Yet, the prognosis and treatment are completely different. Under current clinical practice, these lesions require biopsy for diagnosis and monitoring, often at 6 mo
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Mobile Code for Computers

Background: The Java Virtual Machine's byte-code format (JVM-code) has become the de facto standard for transporting mobile code across the Internet. However, it is generally acknowledged that JVM-code is far from being an ideal mobile code representation - a considerable amount of preprocessing is
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Triple Transgenic Mouse Model of Alzheimer's Disease

University of California, Irvine researchers have developed a novel transgenic mouse model that contains the three major genes that contribute to the hallmark pathological features of Alzheimer's disease. These mice are exceedingly valuable for therapeutic investigations and for basic research aimed
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A Laser System for the Generation of Pulses with Duration in the Pico-second Range and a Narrow Bandwidth

UCI researchers have developed a laser system for the generation of pulses with duration in the picosecond range and a narrow bandwidth. The laser system produces pulses with a duration of about 25 ps. The radiation can be tuned between 410 nm and 2000nm. The bandwidth of the radiation is spectrally
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Fabrication Method for Polymer Thin Films

University researchers have developed a method that allows for the synthesis of a wide variety of polymer thin films, the fabrication method of which can be combined with photolithography to create surface patterns. Thin film thickness is controlled from 1 nm to the submicron range. The method also
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Method and Apparatus for Electroforming Tissue

Background: The functional and esthetic defects in the head and neck that result from surgery, trauma, or congenital malformations have led to the development of surgical techniques to reshape cartilage. Conventional reconstructive techniques (e.g., otoplasty, rhinoplasty, tracheoplasty) involve th
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Ion Optical Element for Use in Controlling Charged Particle Beams

Background: Previously, reflectrons consisted of stacks of discrete electrodes. These stacks can be expensive to manufacture and contain inherent imperfections - the field over the assembly of electrodes is not precisely linear. Technology: UC researchers have devised a solution that replaces th
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Vascularized Artificial Tissue

Background: There exists a need for thick artificial tissues to cover large tissue defects following trauma or surgical resection of tumor. The primary limitation in the design of these tissues as well as other complex thick tissues is a vascular supply to deliver oxygen and essential nutrients.
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Suppression of Jet Noise from Aircraft

University researchers have developed a method to achieve significant noise reduction with simple modifications of the engine exhaust. These modifications have a very small effect on engine thrust. Moreover, the nature of the modification allows for on-demand activation of the noise suppression mech
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Depth Profiling of the Skin Structure in Vivo

University researchers have developed a photoacoustic probe contained within a handpiece for use in contact with the skin. The laser pulses generate acoustic waves at the subsurface absorption sites. It is believed that no known use of photoacoustics has been used for this purpose in the past. Previ
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RF MEMS Technology for Fabricating RF MEMS Switches

University researchers have invented a low-cost, high performance, and substrate independent RF MEMS technology for RF MEMS switch fabrication with high yield and reliability. It is compatible with well established printed circuit board (PCB) technology and allows the choice of any substrate with de
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Methods for Assessing the Condition of Bone In-Vivo Using Non-Ionizing Radiation

Background: The ability to assess the health and condition of bone tissue is important since bone tissue viability is closely linked to composition, structure, and physiology. Traditional methods for assessing the condition of bone involve the use of X-rays (via electron density) and ultrasound (vi
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Selective Inhibition of Enzyme Isoforms of Nitric Oxide Synthetase

University of California, Irvine researchers have discovered a method to design and use selective inhibitors against a family of nitric oxide synthetase isoforms that control the production of nitric oxide (NO). X-ray crystallography was utilized to generate isoform specific NOS-inhibitor complexes
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Nanowires as Fast Chemical Sensors

Background: Recent years have witnessed a significant interest in biological applications of novel solid-state nanomaterials. The unique physical properties of molecular or nanoscale solids when utilized in conjunction with the biomolecular recognition capabilities could lead to miniaturization of
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A Polymeric Micro-Cantilever Resonator Array and Its Implications in Auditory Prostheses

Background: Ten percent of the general population suffers from hearing loss and that number rises to thirty five percent for people over sixty-five years of age. However, current digital hearing aids and cochlear implants to ameliorate hearing loss have their disadvantages. Some of these include hi
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High-Resolution X-Ray Crystal Structures of Tritrichomonas Foetus Inosine Monophosphate Dehydrogenase as Lead Compound for Structure-Based Drug Design

Background: Trichomoniasis is a venereal disease of cattle caused by a protozoan parasite, Tritrichomonas foetus. The disease has been reported worldwide with an estimated economic loss to the U.S. beef industry exceeding $100 million annually due to reduced conception rates, lowered weaning weight
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A Reduction in Sumoylation of Cellular Proteins Reduces Polyglutamine Toxicity in Vivo in a Drosophila Fruit Fly Model of Huntington's Disease

Background: Huntington's disease (HD) is a fatal, autosomal dominant, progressive neurodegenerative disorder. Clinical symptoms are progressive and include chorea, impaired voluntary movement, behavioral changes and dementia. Present therapies are limited to alleviating these symptoms without any i
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Novel, Stand-alone, Closed Ventilating Circle Circuit with CO2 Absorption and Sensitive Spirometry Measures Pulmonary O2 Uptake During Anesthesia

Background: The volume of O2 consumption (VO2) and the volume of CO2 production (VCO2) can give vital information about a patient under anesthesia. For example, monitoring VO2 can detect non-steady state critical events and changes in tissue metabolism in anesthetized patients. However, no accurate
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New Clinical Bymixer for Fast-Response, Adjustable Measurement of Mixed Expired Gas Fractions in the Anesthesia Circle Circuit

Background: The volume of O2 consumption (VO2) and the volume of CO2 production (VCO2) can give vital information about a patient under anesthesia. For example, monitoring VO2 can detect non-steady state critical events and changes in tissue metabolism in anesthetized patients. However, VO2 and VCO
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Device for Controlling and Limiting Thermal Injury to Tissue During Thermal procedures

Background: Various thermal techniques are under development that generate heat in the nasal septum. One concern related to these procedures is that heating the septum or its component structures (e.g. cartilage, bone, mucous membrane, perichondrium, blood vessel) will result in full thickness inju
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A New Burr Design

Background: One of the great limitations in spine surgery is the difficulty with removing bone without damaging adjacent soft structures (such as the spinal cord, nerves, and durra). This difficulty has significantly restricted the ability to do effective endoscopic surgery around the spine. Shield
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An Antibody-based Method for Reducing Ocular Inflammation which Can Aid in Corneal Transplantation

HSV keratinitis is characterized, in part, by scarring of the eye as a result of HSV reactivation. To date, corneal transplantation is the standard treatment method. A significant obstacle preventing successful corneal transplantation is inflammation that occurs within the eye (ocular inflammation).
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Multi Stage Control Architecture for Error Suppression in Micromachined Gyroscopes

Background: In the past, for micromachined gyroscopes to operate with highest precision required characterization by the manufacturer followed with post processing such as laser trimming, ion beam milling or selective material deposition and integration of feedback control. This process is expensiv
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Microfluidic Devices for Controlled Viscous Shearing and Formation of Amphiphilic Vesicles

Background: Amphiphilic vesicles are artificial cells with applications in drug delivery (including biomolecular nanomedicine such as DNA, peptides, proteins), combinatorial chemistry, nanoscale chemical reaction chambers, biomolecular devices (power, optical, electrical), and various biosensors.
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R6G9 Treatment Improves Viral-Induced Neurological Disease

Background: Multiple Sclerosis (MS) is a devastating neurological disease. MS patients often experience neurologic dysfunction believed to be the result of infiltration of immune cells, inflammation of the central nervous system and eventual nerve damage. Technology: Researchers at the Universit
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Fluorescing Materials for 3D Memory Devices

Background: Photochromic fulgides are capable of reversible light-induced coloration. These organic compounds exhibit several important physical properties such as thermal stability of both colorless and colored forms, high photoreaction efficiency, high fatigue resistance to repeated coloration-bl
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Reagents and Methods for Diagnosis of Attention Deficit Hyperactivity Disorder

Background: Attention Deficit Hyperactivity Disorder (ADHD) is the most prevalent disorder of early childhood. It affects an estimated 3-6% of elementary school children. ADHD consists of developmentally inappropriate inattention, impulsivity, and hyperactivity with early onset (before the age of 7
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Top-Gate Carbon Nanotube Field Effect Transistor

Background: A carbon nanotube (CNT) is a one-dimensional molecular wire which is believed to have many potential applications in upgrading the density and performance of electronic information systems. Technology: This invention solves six potential problems with incorporating CNT's into next ge
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Treatment of Bladder and Urinary Tract Cancers Using Chalcone and Flavone Derivatives

Background: About 56,000 new cases of bladder cancer are diagnosed in the United States each year and approximately 12,000 Americans will die of the disease. Drawbacks of older cisplatin based therapies, such as MVAC, include toxicity and poor patient tolerance. Newer therapies such as paclitaxel d
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High-Isolation Tunable MEMS Capacitive Switch

Background: For a typical MEMS switch, the resonant frequency is around 20 to 30 GHz which can not be employed by commercial wireless systems operating at a frequency band of 2 to 8 GHz. This resonant frequency can be tuned by changing the inductance of the switch membrane. When inductance is incre
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New Protein Resistant and Biodegradable Biopolymer

Background: The ability to resist nonspecific protein adsorption (protein resistance) is an indicator of a material's biological inertness or biocompatibility. Protein resistant biomaterials such as the commonly used poly(ethylene glycol) (PEG) have been used in a number of applications such as pro
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Photonic Slab with Axially Frozen Mode

Background: A unidirectional gyrotropic photonic crystal allows electromagnetic wave propagation in a certain direction at a certain frequency and at the same time, impedes electromagnetic wave propagation in the opposite direction. The electromagnetic wave with impeded propagation, called the "fro
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Method for Quantitative Digital Color Imaging of Objects

Background: In many disciplines, quantitative measurements of color are required to evaluate nondestructively the state of an object (e.g., quality of produce). This characterization is typically performed using contact point measurement devices. A limitation of these devices is that multiple measu
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Design and Synthesis of PET Radioligands for alpha 4 beta 2 Nicotinic Acetylcholine Receptors

Background: Nicotinic acetylcholine receptors (nAChRs) belong to the superfamily of ligand-gated ion channels and are distributed widely in the human and nonhuman brain. Several nAChRs have been identified and characterized pharmacologically and have distinct patterns of distribution in the brain.
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Broadband Distributed-Mass Micromachined Gyroscope

University researchers have invented a distributed-mass micromachined gyroscope which minimizes quadrature error, eliminates effects of directional residual stresses, and completely decouples the drive and sense modes. The device has multiple drive-mode oscillators, distributed symmetrically around
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Melanin Concentrating Hormone Receptor Small Molecule Antagonists for the Treatment of Obesity and Related Metabolic Disorders

In mammals, Melanin Concentrating Hormone (MCH), a GPCR, has been shown to regulate food consumption and energy metabolism. Central administration of MCH has been shown to promote feeding while mRNA levels of the MCH Receptor 1 (MCHR1) rise as a result of starvation and leptin deficiency. MCH also s
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Nickel Diimine Cyclophane Catalysts for High Temperature Gas Phase Olefin Polymerization

Late transition metal olefin polymerization catalysts have received much attention recently because they can produce polyolefins with interesting new branching topologies and have better tolerance to functional groups. The PdII and NiII alpha diimine complexes are such catalysts, however they respec
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Neuropeptide S (NPS) as a Treatment for Anxiety, Sleep Disorders, Attention Deficit Hyperactivity Disorder, Attention Deficit Disorder, and Asthma

Background: Patent "WO02/31145" discloses a newly deorphanized GPCR system, Neuropeptide S (NPS), the endogenous ligand, and its cognate GPCR. However this patent does not detail the pharmacological or physiological function of NPS and its GPCR. University of California, Irvine researchers have cha
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Methods for Treating Port Wine Stain Birth Marks, Hemangiomas and Other Conditions Caused By Aberrant Blood Vessels

Background: Cutaneous vascular lesions including port wine stains (PWS) and hemangiomas are frequently treated with laser and light devices. The pulsed dye laser (PDL) is the current standard means of treatment care for PWS and achieves effect by selectively targeting tissue vasculature. However, f
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Using Female Endocrine Hormones to Improve Psoriasis

Background: The most commonly prescribed medications for severe psoriasis are methotrexate and cyclosporine. Both these medications have serious side effects. The next line of treatment includes phototherapy but this is limited by the availability of light boxes in the dermatologist's office. Biolo
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Optimal Spatial Sub-channel Resources Allocation Mechanism for Sustainable Bit Rate Wireless Conduits

Background: The latest video compression standard (MPEG-4) has moved the wireless industry one step closer to the world of high quality multimedia services. Commercial wireless MPEG-4 video codec systems can already support up to Level 3 of the MPEG Simple Visual Profile. However, the issue of how
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Polymeric Valves for Controlled Drug Delivery

Background: Biochips can be used in vitro or in vivo to deliver small, controlled amounts of chemicals or other molecules at controlled times and rates. Current delivery release mechanisms include electrochemical dissolution of thin anode membranes covering microreservoirs filled with drug. The met
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Fuel Cell System for Aircraft Propulsion

Background: Aircraft thrust is traditionally come from a combustion engine (internal combustion or gas turbine) coupled to either a propeller or a nozzle to produce thrust. These systems deliver high performance but also have high emissions and low fuel efficiency. Some proposals have used fuel cel
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Microfluidic Flow Transducer Based on the Measurement of Electrical Admittance

Background: The development of multifunctional, high throughput lab-on-a-chip depends heavily on the ability to measure flow rate and perform quantitative analysis of fluids in minute volumes. Traditionally, there have been many microelectromechanical system (MEMS) based flow sensors for gaseous fl
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Immunoassay Apparatus and Method Using Flow Induced Electrical Admittance

Background: There remains a need for new immunoassay techniques and related devices for performing immunoassays with improved simplicity, efficiency and/or accuracy. The present invention provides for a new immunoassay method, namely, a flow induced electrical admittance immunoassay (FIEAI). This p
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A Microfluidic Dynamic Vapor Control System

Background: Controlling the chemistry of small drops is troublesome owing to the difficulty in handling and metering small volumes. To change the chemistry of a 50nl drop by 10% would require adding or removing a 5nl quantity - very difficult. As a result, most nanovolume assays are set up once and
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Automatic Detection and Diagnostics of Diabetic Retinopathy

Background: Diabetes is a condition that affects blood vessels throughout the body, particularly in the kidneys and eyes. Diabetic retinopathy is a complication of diabetes and is the leading cause of new blindness in the United States. Diabetic retinopathy results when diabetes affects vessels in
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A Broadband Amplifier with Huge Gain-bandwidth Product and Low Power Consumption

Background: Without a distributed amplifier, most broadband amplifier bandwidths can be achieved around 1/10 to 1/3 of their fT only. Therefore, a high bandwidth amplifier requires high fT (at least 3-10 times of the amplifier bandwidth) transistors in order to achieve high bandwidth. Unfortunately
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Antibodies that Bind and Detect Acute Lesions in MS Brains

Background: In patients suffering from multiple sclerosis (MS) B cells, stimulated by axon antigens, infiltrate central nervous system. Technology: The inventors discovered a new class of antibodies that specifically binds to axons in early stage of acute lesions in multiple sclerosis (MS) brain
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Regulated Growth Factor Delivery for Nerve Regeneration

Background: Options for successful repair of peripheral nerves after traumatic injury remain suboptimal. Current strategies are limited to transfer of donor nerves from functional areas, with substantial donor-site morbidity and variable outcomes. The development of tissue-engineering strategies of
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Composite Transistors for Compensation of HBT Self-heating Effect and Enhancement of HBT Linearity

Background: Heterojunction bipolar transistors (HBT's) are the key components in the high output power densities circuits at microwave frequencies and are increasingly being utilized for large signal applications such as power amplifiers, oscillators, and mixers. These high power densities in HBT c
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Invention of New Dendritic Amphiphiles

Background: Amphiphilic compounds are of general interest in numerous disciplines in life sciences, especially in pharmacology and general chemistry, and numerous amphiphilic compounds are known in the art. However, traditional amphiphilic compounds usually forms micelles or aggregates that are oft
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Nrf1 Deficient Mice as a Model for Liver Cancer and Non-Alcoholic Steatohepatitis

Background: Antioxidant and xenobiotic metabolizing enzymes are critical in the protection against chemically induced oxidative/electrophilic stress in cells that cause damage, DNA mutation, apoptosis, and cancer. Transcription of these cytoprotective genes and xenobiotic metabolizing genes is regu
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Use of Laser-Induced Fluorescence for Determination of Root Canal Pathology and Localization of Pathological Tissues to Facilitate Endodontic Therapy

Background: Currently endodontic therapy is based upon radiographic information and tactile feedback. Direct detection and localization of infected dentin and pupal tissue has not been possible. It has been determined that when excited at appropriate wavelengths of light, the fluorescence emission
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Somatic Mitochondrial DNA (mtDNA) Control Region (CR) Mutations Associated with Alzheimer's Disease: the Cause and Diagnosis

Background: Sporadic Alzheimer's Disease (AD) has been associated with defects in mitochondrial oxidative phosphorylation (OXPHOS) as well as inherited and somatic mitochondrial DNA (mtDNA) mutations. To determine if mtDNA mutations contribute more generally to the etiology of AD, we have investiga
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A Diffusive Probe for Quantification of Optical Properties of Superficial Layers

Background: Diffuse optical spectroscopy (DOS) has been successfully employed for quantitative determination of in vivo optical properties and chromophore concentrations of deep tissues such as breast and brain. This invention is a method and probe design for obtaining quantitative optical properti
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Torsional Z-axis Surface-Micromachined Gyroscope

Background: The limited thickness of structural layers attained in current surface-micromachining processes results in very small sensing capacitances and higher actuation voltages, restricting the performance of the surface-micromachined gyroscopes. Technology: University researchers have devel
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Post-Release Capacitance Enhancement in Micromachined Devices

Background: Capacitive detection and actuation are commonly used in micromachined devices due to simplicity of implementation and effectiveness. However, the performance of capacitive sensors and actuators highly depends on the nominal capacitance of the microsystem. For example, in capacitive micr
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Cell Encapsulation on a Microfluidic Platform

Background: Cell encapsulation is a highly useful tool in cell culturing, assay, and cell-based therapy applications. Encapsulation has traditionally been accomplished by extrusion through a nozzle, forming an air/water emulsion, into a bath containing a polymerizing agent. However, this batch proc
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Fluoro-Free Guidewire for Improved Colonscope

Background: Endoscopes with a soft insertion unit can be inserted into the lumen of a body cavity to diagnose problems located in a deep region in the body cavity without the necessity of incision and can also be used to guide treatment appliances to a desired location within the body cavity. In th
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Method of Fabrication of Self-enclosed Microchannels and/or Chambers with or Without Integrated Interconnects and Electrodes

Background: Conventional methods that create fluidic channels using photopolymers create channels and chambers by-coating, patterning, and developing each layer sequentially. These conventional methods of fabricating microchannels also involve using molds or patterning channels onto a flat substrat
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New Polymeric Biomaterials

Technology: The invention is on new polymeric biomaterials. The new biomaterials were created by chemical synthesis with carbohydrates and amino acids as building blocks. The biopolymers have a specific alternating structure between carbohydrate and peptide units. Application: The new biomateria
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Selective Inhibitors of Monoacylglycerol Lipase as a Treatment for Neurological Disorders

Background: Acute stress elicits the rapid formation of two endocanabinoid ligands, 2-arachidonoylglycerol (2-AG) and anandamide (AEA). These endogenous lipids bind to the CB1 cannabinoid receptor and inhibit pain sensation by acting as non-opioid stress-induced analgesics. AEA and 2-AG are metabol
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Transgenic Mouse Model for Screening Analgesic Agents

Background: UC Case No.: 2004-692 Patent Application Publication No.: WO/2006/017293 International Application No.: PCT/US2005/024697 This invention is an animal model and various cell-based models to determine nociception, pain transduction, and pain threshold. Researchers at the University
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A New Tandem-Affinity Tag for Two-Step Protein Purification under Fully Denaturing Conditions

Background: Preservation of posttranslational modifications during purification is crucial for successful mass spectrometric analyses of protein modifications. Current tandem-affinity purification strategies require native conditions and are therefore susceptible to loss of posttranslational modifi
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Humid Air Turbine - Combined Cycle Hybrid

Background: The Humid Air Turbine (HAT) cycle is an intercooled gas turbine-based cycle which utilizes generation of water vapor by directly contacting pressurized air leaving a compressor of the gas turbine with hot water in a counter-current humidifier and circulating the water leaving the humidi
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Microscope Immersion Fluid Applicator

Background: Microscopy is an important tool used by all researchers in the scientific community. Often, a microscope user will first scan the specimen with a low power dry objective and then wish to switch to an oil, water or glycerin immersion objective to increase optical resolution. In other cas
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New Multiphase LLC Resonant Voltage Regulators for Next Generation Microprocessors

Background: Recent developments in semiconductor manufacturing technology have resulted in unprecedented density of transistor elements per silicon area. This new technology facilitates a dramatic increase in circuit complexity of the modern computer and communication hardware. With transistors dim
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Methods for Making 2D Nanoscale PN Junctions and Junction Arrays

Background: Silicon-based device structures capable of laser emission are highly desirable since they allow realization of integrated opto-electronic circuits. Unfortunately, it is generally believed that silicon's inherent bandgap prevents its use, alone, as lasing media. Numerous approaches to ov
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Methods for Assessing the Temperature of Deep Tissue in vivo Using Non-ionizing Radiation

Background: Measuring temperature in tissue is highly relevant to treatments applied to tissue in which the tissue becomes heated. This includes methods that treat tissue with RF (Radio Frequency) such as radio frequency ablation of cancer, hyperthermia treatments of cancers and cosmetic skin treat
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Total Ankle Arthroplasty

Background: Total ankle arthroplasty (TAA) is the process of replacing a diseased ankle with a prosthetic ankle. Over the years there have been several efforts to provide a total ankle replacement solution. However, all such current solutions have significant drawbacks, including complications relat
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Method to Characterize Exhaled Nitric Oxide from the Airways Using a Sequence of Breathhold Maneuvers

Background: Exhaled nitric oxide (NO) arises from both airway and alveolar regions of the lungs, which provides an opportunity to characterize region-specific inflammation. Current methodologies rely on vital capacity breathing maneuvers and controlled exhalation flow rates, which can be difficult
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Fabrication of Suspended Carbon Micro and Nano-scale Structures

Recent attention has focused on high aspect ratio carbon micro-electromechanical (C-MEMS) because of the many applications possible, such as micro-electrodes in electromechanical sensors and miniaturized energy storage/energy conversion devices. Further, suspended micro/nano carbon structures exhibi
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Rapid Bio-Molecules Detection by Adjacent Impedance Probing (AIP) Techniques

Background: Today, most detection schemes for DNA, proteins and other large biomolecules involve luminescent measurements using a variety of labels (i.e. fluorescent and/or chemiluminescent probes, photoproteins, etc.) and the binding of these large molecules to their complementary molecular struct
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Method and Apparatus of Using 3D Conductive Structures in Dielectrophoretic Separation Applications

Background: Researchers estimate that 80% of all machine failures are due to wear and that 1.3~1.6% of the GNP is lost to degradation of machinery due to friction-related wear. The abnormal abrasive wear due to lubricant contamination in marine diesel engines eclipses that of normal wear and the ga
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Efficient Transaction Based Modeling with Cycle Count Accurate at Transaction Boundary (CCATB) Models

Background: In the past, several modeling abstraction levels were proposed to improve simulation speed and modeling time over detailed cycle accurate (CA) models. The Pin Accurate Bus Cycle Accurate (PA-BCA) modeling abstraction maintained cycle accuracy at every cycle boundary for communication in
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Glycosylase enzymes

DOMAIN Glycosylases have found use in a number of methods aimed at analyzing DNA for the presence of altered nucleobases that could result from ionizing radiation or chemical oxidants, identifying mismatched base pairs, studying repair of abasic sites in double-stranded DNA and as a means to prevent
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Determining leakage through a heart valve

Determining the severity of a leakage through a heart valve is important. There are several parameters that are clinically interesting in this regard: the area of the lesion, the flow or flow rate through the lesion and the geometry of the lesion. These three parameters are not easy to measure. Curr
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Applications of Photonic Crystals with Degenerate Spectral Band Edge

In a vacuum, light propagates with a constant velocity, while in an optically transparent non-dispersive media, the speed of light propagation can be different. At optical frequencies, the refractive index of transparent materials usually does not exceed several units, and the speed of light propaga
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High Density Micromachined Electrode Arrays Usable for Auditory Nerve Implants and Related Methods

Background: Auditory prostheses using microelectrode arrays suffer from a number of limitations. Issues that were not resolved are electrode size, the need for electrical wires to communicate with and transfer power to the arrays, and the need for hand assembly of the devices. Technology: Resear
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Phage-displayed Peptide Library with Affinity for Bacterial Elongation Factor Tu

Background: The highly abundant GTP binding protein elongation factor Tu (EF-Tu) fulfills multiple roles in bacterial protein biosynthesis. EF-Tu also binds other ligands, including four structurally distinct families of antibiotics. The lack of sequence homology among the identified EF-Tu ligands
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Environmentally-Sensitive Reconfigurable Antenna

Background: With the exception of light-based sensors, that change their light interaction properties, all sensors require some power in order to operate and provide a signal to a remote source. Light-based systems are readily blocked by typical obstructions such as buildings, trees, and vegetation
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MEMRI (manganese enhanced MRI)

DOMAIN Within an ageing population, ischemic heart disease (IHD) and secondary heart failure represent major challenges underlining a demand for diagnostic imaging to identify IHD in its different stages and forms. There is also a need to diagnose heart failure developing after myocardial infarction
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Methods and Compostions for the Treatment of Immune Disorders and Regulation of Cytokine and Growth Factor Signaling

Categories: Pharmaceuticals: Central Nervous System Disorders, Immune and Inflammatory Disorders Biotechnology: Assays, Diagnostics, Model Systems Background: Mgat5 is an enzyme that glycosylates T-cell receptors to modulate T-cell activation and autoimmune response. Mgat5 Null PL/J Mice were
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Methods of Improving Memory and Cognition

Technology: University of California, Irvine researchers have discovered a new method of improving memory by selectively modulating nuclear receptor cell signaling. The technology has been validated in several animal models of memory in both rats and mice. Application: This technology provides a
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