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Position-Specific Insertion Vectors and Method of Using Same

Background: Retrovirus vectors infect cells at high efficiency and are capable of integrating DNA copies of themselves into a host genome. Such vectors are, in many ways, desirable for introduction and expression of exogenous DNA sequences in animal cells. In gene therapy or in the production of tr
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Assay for and Treatment of Autoimmune Disease

The invention is directed to prognosis, diagnosis and treatment of autoimmune diseases, including SLE (systemic lupus erythematosus), type-1 diabetes, experimental allergic encephalomyelitis (EAE) and other, which demonstrate uniquely the presence abnormal double-negative (CD4- and CD8-) T cells exp
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Cash-My-Check

Cash-My-Check (CMC) is a self service check cashing machine that provides real-time check verification for payroll, personal and corporate checks. The Cash-My-Check (CMC) combines form and functionality to provide the best check cashing experience in the retail market today. With a variety of per
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Petrol Saving Device

This device is based on the patent filed for the method of stabilizing the turbulence created by valves in a flow system (patent pending). Based on the technology we fix this device through pneumatic tubes before and after the throttle valve (carburetor) in a petrol vehicle,which controls the turbu
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Method of identifying and registering entities and an assembly of hardware and software for applying such a method

This is a methode for implementation of identification code systems in a DNS (Domain Name System) providing domains + web pages, and services to clients. Practically this means that all kind of identification code (like telephone numbers isbn or social sec. nr) systems exclusively can be implemented
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Lineographic Alphanumeric Data Input System

This input system is designed for entering text into portable electronic devices, such as cell phones, hand held computers and intelligent phones, by making short linear traces or taps with a finger or thumb on a touch sensitive keypad. The system allows the user to enter operational commands on th
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Absorption system of shock waves and armor for military vehicles

Absorption system of shock waves and armor for military vehicles System absorption of shock waves for armored military vehicles and construction consisting of the body and interior of the vehicle by a structure pre hollow interior frameworks available boxes (Fig. 1) with a considerable thickness a
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Device for Organizing the Administration of Pills At Predetermined Time Intervals

A device for organizing the administration of pills at predetermined time intervals, characterized in that it has a main body used as an individual tissue ring with an opening, through which tissues can be inserted, and that the main body includes at least one compartment (4,4',4''), which can hold
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Method of Inhibiting the Transport of L-glutamate

Background: L-Glutamate is one of the most abundant excitatory neurotransmitters in the mammalian brain and, as such, is responsible for many synaptic transmissions in the central nervous system. Yet, while other neurotransmitters are degraded rapidly to terminate the transmitter signal, L-glutamat
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Isolation of Biological Materials

Currently, flow cytometry is the only method available for the purification of specific chromosomes. The current flow cytometry method requires a long time to sort large quantities of cellular starting material for a single chromosome. Furthermore, species with similarly sized chromosomes, such
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Data Compression of Time-Varying Images

Background: Current methods of transmitting time-varying images involve encoding the digital image information into a set of still frames. To reduce the bandwidth necessary to transmit the full image, compression techniques are used to eliminate statistically redundant information in the pixel inte
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Drugs to Improve Synaptic Transmission

About 5% of the general population over the age of 65 suffers from Alzheimer's disease for which there is no known treatment. Synaptic connections in the hippocampus, a brain region known to be important for learning and memory are especially vulnerable to Alzheimer's disease. This presumably reflec
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Transgenic Animal Models for Alzheimer's Disease

The present invention provides non-human, transgenic animals for use as a model for the study of Alzheimer's Disease. The animals exhibit pathology associated with Alzheimer's Disease. The phenotype is conferred in the animals by the introduction of an amyloid-containing polypeptide fragment of amyl
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Method for Distributed Redundant Execution of Program Modules

Background: Several schemes have been implemented in distributed computer systems which recover execution of program modules when hardware and software failures occur. The distributed recovery block scheme executes a primary and backup copy of a program on multiple processors. The processors commun
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Novel Device for Determining the Viability of Human Myocardium Or Other Animal Tissues

Background: The last decade of cardiac surgery has witnessed significant strides towards better understanding and better management of previously lethal cardiac pathology. Such developments have led to a general recognition of previously unknown conditions such as myocardial stunning and hibernatio
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Tissue Viability Monitor

Background: The last decade of cardiac surgery has witnessed significant strides towards better understanding and better management of previously lethal cardiac pathology. Such developments have led to a general recognition of previously unknown conditions such as myocardial stunning and hibernatio
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Voltage-Gated Potassium Channel Gene, Kv1.7, Vectors and Host Cells Comprising the Same, and Recombinant Methods Of…

It has long been believed that the secretion of insulin from pancreatic beta cells in the Islets of Langerhans is induced by the presence of glucose at the outer surface of the beta cell membrane. This secretion is regulated through a series of processes at the surface of the cell which allow the in
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A New Polymerization Method for Polymethylene

Background: The most common method for manufacturing polyolefins and their derivatives is by polymerization of olefin monomers with Ziegler-Natta catalysts or by the use of free radical, nucleophilic, or electrophilic initiators. Although one can achieve high molecular weights with these methods, t
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A Novel Method for Eliminating Mach Waves in Supersonic Jets

Aircraft designers face the technological challenge of reducing the noise produced by supersonic aircraft exhausts. These exhausts, if left untreated, produce environmentally unacceptable levels of noise. Much of this noise is due to Mach waves, the shock waves attached to turbulent eddies moving at
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Method of Eliminating Mach Waves from Supersonic Jets

Background: Community noise is one of the major technological challenges faced by designers of future supersonic transports, such as the High-Speed Civil Transport (HSCT). The hot supersonic jets exhausting from the engines of such aircraft are powerful noise generators, especially during take-off.
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One Cycle Control of Bipolar Switching Power Amplifiers

Researchers at the Power Electronics Laboratory at University of California, Irvine, received a U.S. patent for a device that uses one cycle control for controlling DC-to-AC switching converters. This is achieved by forcing the average of a controlled switched variable to be exactly equal to the con
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A Method and Apparatus for Use in Antifibrotic Therapy of Ophthalmic Filtration Surgery

A Method And Apparatus For Use In Antifibrotic Therapy Of Ophthalmic Filtration Surgery
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Humidity and Temperature Sensor Device for the Determination of Oxygen Consumption in Medical Applications

Background: The determination of oxygen consumption is an important monitor of normal cardiopulmonary and tissue function in anesthesia and critical care medicine. This requires accurate measurement of inhaled and exhaled volumes. Traditionally, it has been very difficult to measure the extra volum
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Aluminum - Lithium Alloy Metal Matrix Composites

For high temperature aerospace application, Ti alloys are often utilized to produce structural parts. However, the cost has often been the drawback. Finding an alternative has motivated the development of advanced aluminum alloys to satisfy the requirement of titanium alloys. Researchers of the Univ
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Phototherapeutic Inactivation of Ocular Viruses

A variety of diseases could be significantly controlled using this new treatment for viral ocular infections in humans, including cytomegalovirus (CMV) retinitis in AIDS patients, herpes keratitis, and viral conjunctivitis. CMV retinitis is the most common ocular opportunistic infection and the lead
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Enhancement of Host Defense Via Receptor(s) for C1q

Background: As the development of protein products and peptide mimetics becomes more prevalent in the biotechnology and pharmaceutical industries, the ability to mimic the protective and modulate the inflammatory effects of the recognition protein of the classical complement cascade in blood and bo
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A General Constant Frequency Pulse-Width Modulator and Its Applications

Background: Switching converters are commonly used to provide DC to DC, DC to AC, AC to DC, and AC to AC conversion of electrical waveforms. These converters are often categorized by applicable circuit configuration and/or capabilities, and include buck converters (where the load voltage is less th
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Brain Aging Assay

Researchers at the University of California, Irvine, have created a model of brain aging in cultured brain slices. These slices provide an in vitro model for the following: 1) the study of brain aging; 2) an assay for anti-brain aging drugs; and 3) therapeutics directed at the clinical condition ref
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Mixing Enhancement Using Propulsive Means

A novel mixing enhancement method exploits a previously unknown flow instability to enhance mixing in a compressible jet flow or in a flow (gaseous of liquid) in contact with the compressible jet flow. No mechanical mixers and no actuators of any kind are used. Nozzle shapes are streamlined and simp
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Prevention of Ice Formation on Tissue Surfaces Caused By Cooling During Laser Surgery

Background: A complication of using a cryogen gas to provide cooling during laser irradiation of biological tissues is the formation of ice crystals. This formation of ice on the tissue surface causes two major problems: 1) it decreases the incident light dosage due to optical scattering by the cry
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Diagnostic Marker and Novel Therapeutic Target for Neurodegenerative Disorders

Scientists at the University of California, Irvine, have isolated a candidate gene that may be responsible for increasing the risk of schizophrenia and bipolar disorder. This elusive gene encodes for a potassium ion channel that acts like an "off switch" by dampening electrical activity in neurons.
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Novel and Selective Inhibitors of HIV-1 Integrase

In the ongoing battle against the human immunodeficiency virus (HIV), researchers at the University of California, Irvine, have synthesized novel compounds that inhibit the protein HIV Integrase and prevent the virus from replicating, thus providing an alternative to currently available AIDS therapy
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Modulation of Cell Growth and Growth Factor Signaling Through Removal of Glypicans

Background: Membrane associated heparin sulfate proteoglycans (HSPGs) have been shown to play important roles in many aspects of cell behavior, including cell-cell and cell-extracellular matrix adhesion and growth factor signaling. Glypicans, members of the HSPGs, are a family of polypeptides that
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Treatment for Circadian Performance Deficits By Upmodulation of Central Glutamate Receptors

Background: Alertness and general physical and mental performance are impaired during normal sleep periods compared to those during normal waking periods. Unlike stimulants such as caffeine or methamphetamine, certain glutamatergic enhancer compounds have been shown to improve memory and performace
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Use of Perillyl Alcohol in Organ Transplantation

Background: Current state of the art in the field of organ transplantation employs various immunosuppressive agents to prevent post-surgical allograft rejection by the host. However, these pharmacological agents often result in many adverse side effects due to the quantities of medication that are
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Donor Organ Preservation for Transplantation Using a Hemoglobin Based Solution

During heart transplantation, the heart must be preserved while it is transported from donor to recipient. Standard techniques call for the heart to be immersed and cooled in cardioplegia or saline solution. Unfortunately, this method does not deliver necessary oxygen, nutrients, and electrolytes to
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Use of Infectious and Pathogenic Clone of a Lung Cancer-Inducing Retrovirus for Generation of Therapeutic Reagents and Diagnostic Tests

Background: Jaagsiekte sheep retrovirus (JSRV) causes broncheolo-alveolar carcinoma in sheep and is a significant veterinary problem world-wide. Clinically and histopathologically, this disease has strong resemblance to broncheolo-alveolar carcinoma (BAC) in humans which accounts for approximately
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A New Process of Adding Alkyl Groups to Organic Substrates Using TmI2(MeOCH2CH2OMe)3

Background: In the pharmaceutical industry, synthetic chemists often alkylate starting compounds to generate compounds that have more desirable properties. However, the current reagents used in this modification process can be expensive or harmful to the chemist. Technology: Researchers at the U
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A Novel Treatment for Upper Respiratory Tract Irritation and Cough

Background: Traditional cough suppression therapy has included palliatives in the form of herbal remedies, narcotics such as codeine, and local anesthetics such as benzonatate. The anesthetic compounds have limited efficacy, while the narcotics cause severe side effects because they work through th
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Protocol and Software Organization Method for Real-Time Fault-Tolerant Multicasts in Computer Networks

Background: Components of application systems based on a network of computing nodes (e.g., PC's and workstations) often maintain the client-server relationship among themselves. For the sake of attaining high system reliability and performance, servers are often replicated. These servers must then
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Corneal Transplantation

Background: Corneal damage due to accident or disease results in varying degrees of blindness in millions of individuals throughout the planet. In some cases it is possible to restore vision by a corneal transplant. A full-thickness transplant (penetrating keratoplasty, PK) runs a high risk of graf
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High Speed Circuit Board Writing

A method of printing lines on circuit boards from computer information in a manner similar to using an inkjet printer. Utilizing capillary stream break-up of molten metal droplets, this novel approach is capable of printing very fine lines on the order of 10 microns wide and many centimeters long at
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High Speed Fabrication of Highly Uniform Metallic Spheres

An inexpensive method of generating highly uniform metallic balls from capillary stream break-up at ultra high speeds. Manufacture of solder balls (and other metallic balls), commonly used in the electronics industry, can be achieved using this method. Due to the nature of the droplet formation from
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Treatment for Prostate Cancer

Background: Polyamines are naturally synthesized by the body and are involved in many biochemical processes, including cellular proliferation, cell cycle regulation, and protein synthesis. The prostate epithelium synthesizes plyamines at a high rate making the prostate gland having one of the highe
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Molecular Imprinting for the Recognition of Peptides in Aqueous Solution

Molecular imprinting is a process for synthesizing materials that contain highly specific recognition sites for smaller molecules. Today, molecular imprinting is used for many purposes, including the creation of macromolecular binding and catalytic sites and as binding sites for the separation or re
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ADP Glucose Receptor as a Target for Disorders Involving Platelet Aggregation

Background: Recently, activation of the P2Y12 G-protein coupled receptor (GPCRs) has been shown to be central to platelet aggregation. Drugs preventing platelet aggregation are being tested, but one that would be specific to the P2Y12 receptor would capture a large market share. Developing drugs fo
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Platelet Aggregation Inhibitors

Thrombin is an enzyme in the blood that plays a key role in platelet formation during injury. While blood coagulation is essential for a surface wound, platelet activation underlies various pathological situations such as unstable angina pectoris, myocardial infarction and stroke. Thrombin is mediat
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Wnt, Fz, and BMP-6 Receptors for the Treatment and Detection of Colon Cancer

Background: Ectopic activation of the Wnt signaling pathway leads to increased cellular growth and division in experimental organisms and mutations in the Wnt pathway. Wnt pathway genes are tightly linked to the genesis of certain cancers in humans, such as colon cancer. Technology: University o
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Her2/neu Vaccine Protects Against Tumor Growth

Background: Her2/neu is over-expressed in various types of tumor cells, including 20-30% of breast cancers, adenocarcinomas of the ovary, salivary gland, stomach and kidney, colon cancer, and non-small cell lung cancer. Passive immunotherapeutics like Herceptin control and prevent further tumor cel
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DRD4, ADHD

Background: Attention Deficit Hyperactivity Disorder (ADHD) is the most prevalent disorder of early childhood. It affects an estimated 3-6% of elementary school children. ADHD individuals may have abnormal release of dopamine resulting in a "dopamine deficit" that leads to cognitive as well as beha
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Gyrotropic Phontonic Crystals and their Applications in Microwave Technology

By proper spatial arrangement of magnetic and dielectric components, one can construct a magnetic photonic crystal with strong spectral asymmetry (nonreciprocity). The spatial asymmetry, in turn, results in a number of interesting phenomena, in particular, one-way transparency when the magnetic phot
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Novel Retinoblastoma Binding Protein-Related Gene and Potential Use As Cancer Vaccine

Background: The central objective in the development of an effective immunotherapy is the identification of tumor antigens that can elicit antibody and cellular immune responses in humans. Human autologous or allogeneic antibodies from cancer patients are an alternative to the use of monoclonal ant
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Smart Probe with Station for Real Time, Non-Invasive Metrology of Microfluidic Chips

A smart computer controlled bio-microfluidic probe station, which facilitates real-time non-invasive measurements of quantitative, cross sectional information of biological fluid flow at various locations within a bio-fluidic chip. This station would allow for automated, high-throughput testing and
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Screening and Therapeutic Methods for Promoting Wakefulness and Sleep

Background: Current drugs used to modulate sleep and wakefulness cause a number of undesirable side-effects such as anxiety, addiction, and continued sedation. AMPA and PrRP receptors are found in the reticular thalamic nuclear (RTN) region of the brain that has been implicated in sleep rhythms, at
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Miniature Liquid-Fueled Combustion Chamber

Background: Several challenges exist with the development of miniature combustors (sometimes named micro-combustors). The large surface-to-volume ratio can result in substantial heat losses causing inefficiency at the least and flame quenching at the worst. The low residence times causes difficulty
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Method and Apparatus for Tissue Reshaping by Radio Frequency Heating

Background: The functional and esthetic defects in the head and neck that result from surgery, trauma, or congenital malformations have led to the development of surgical techniques to reshape cartilage. Conventional reconstructive techniques (e.g., otoplasty, rhinoplasty, tracheoplasty) involve th
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Novel Cytodiagnostic Markers for Cancer

Background: Cervical cancer is one of the leading causes of cancer-related death in women worldwide. Approximately 500,000 new cases are diagnosed each year and pre-cancerous abnormalities of the cervix occur in far greater numbers of women each year. Cervical carcinomas develop progressively from
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Robotic Hip Swinger

Background: Over 700,000 people in the U.S alone suffer strokes each year often resulting in an impairment of walking ability. A popular approach to locomotion rehabilitation called body weight supported (BWS) training shows promise in improving locomotion after strokes. However the technique invol
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hKCa3/KCNN3 Calcium Activated Potassium Channel: a Diagnostic Marker and Therapeutic Target for Heritable, Neurological and Psychiatric Diseases

University of California, Irvine researchers have discovered SKCa3-1b and SKCa3-1c, two novel isoform variants of the SK3 (also known as KCNN3) gene. The SK3 gene is located on human chromosome 1q21 in a region containing a major susceptibility locus for familial schizophrenia and familial hemiplegi
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Differential Diagnosis of Oral Pathologies

Background: A wide range of oral pathologies have very similar or identical clinical appearance, such as leukoplakia or erythroplakia. Yet, the prognosis and treatment are completely different. Under current clinical practice, these lesions require biopsy for diagnosis and monitoring, often at 6 mo
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Mobile Code for Computers

Background: The Java Virtual Machine's byte-code format (JVM-code) has become the de facto standard for transporting mobile code across the Internet. However, it is generally acknowledged that JVM-code is far from being an ideal mobile code representation - a considerable amount of preprocessing is
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Triple Transgenic Mouse Model of Alzheimer's Disease

University of California, Irvine researchers have developed a novel transgenic mouse model that contains the three major genes that contribute to the hallmark pathological features of Alzheimer's disease. These mice are exceedingly valuable for therapeutic investigations and for basic research aimed
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A Laser System for the Generation of Pulses with Duration in the Pico-second Range and a Narrow Bandwidth

UCI researchers have developed a laser system for the generation of pulses with duration in the picosecond range and a narrow bandwidth. The laser system produces pulses with a duration of about 25 ps. The radiation can be tuned between 410 nm and 2000nm. The bandwidth of the radiation is spectrally
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Fabrication Method for Polymer Thin Films

University researchers have developed a method that allows for the synthesis of a wide variety of polymer thin films, the fabrication method of which can be combined with photolithography to create surface patterns. Thin film thickness is controlled from 1 nm to the submicron range. The method also
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Method and Apparatus for Electroforming Tissue

Background: The functional and esthetic defects in the head and neck that result from surgery, trauma, or congenital malformations have led to the development of surgical techniques to reshape cartilage. Conventional reconstructive techniques (e.g., otoplasty, rhinoplasty, tracheoplasty) involve th
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Ion Optical Element for Use in Controlling Charged Particle Beams

Background: Previously, reflectrons consisted of stacks of discrete electrodes. These stacks can be expensive to manufacture and contain inherent imperfections - the field over the assembly of electrodes is not precisely linear. Technology: UC researchers have devised a solution that replaces th
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Vascularized Artificial Tissue

Background: There exists a need for thick artificial tissues to cover large tissue defects following trauma or surgical resection of tumor. The primary limitation in the design of these tissues as well as other complex thick tissues is a vascular supply to deliver oxygen and essential nutrients.
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Suppression of Jet Noise from Aircraft

University researchers have developed a method to achieve significant noise reduction with simple modifications of the engine exhaust. These modifications have a very small effect on engine thrust. Moreover, the nature of the modification allows for on-demand activation of the noise suppression mech
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Depth Profiling of the Skin Structure in Vivo

University researchers have developed a photoacoustic probe contained within a handpiece for use in contact with the skin. The laser pulses generate acoustic waves at the subsurface absorption sites. It is believed that no known use of photoacoustics has been used for this purpose in the past. Previ
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RF MEMS Technology for Fabricating RF MEMS Switches

University researchers have invented a low-cost, high performance, and substrate independent RF MEMS technology for RF MEMS switch fabrication with high yield and reliability. It is compatible with well established printed circuit board (PCB) technology and allows the choice of any substrate with de
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Methods for Assessing the Condition of Bone In-Vivo Using Non-Ionizing Radiation

Background: The ability to assess the health and condition of bone tissue is important since bone tissue viability is closely linked to composition, structure, and physiology. Traditional methods for assessing the condition of bone involve the use of X-rays (via electron density) and ultrasound (vi
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Selective Inhibition of Enzyme Isoforms of Nitric Oxide Synthetase

University of California, Irvine researchers have discovered a method to design and use selective inhibitors against a family of nitric oxide synthetase isoforms that control the production of nitric oxide (NO). X-ray crystallography was utilized to generate isoform specific NOS-inhibitor complexes
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Nanowires as Fast Chemical Sensors

Background: Recent years have witnessed a significant interest in biological applications of novel solid-state nanomaterials. The unique physical properties of molecular or nanoscale solids when utilized in conjunction with the biomolecular recognition capabilities could lead to miniaturization of
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A Polymeric Micro-Cantilever Resonator Array and Its Implications in Auditory Prostheses

Background: Ten percent of the general population suffers from hearing loss and that number rises to thirty five percent for people over sixty-five years of age. However, current digital hearing aids and cochlear implants to ameliorate hearing loss have their disadvantages. Some of these include hi
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High-Resolution X-Ray Crystal Structures of Tritrichomonas Foetus Inosine Monophosphate Dehydrogenase as Lead Compound for Structure-Based Drug Design

Background: Trichomoniasis is a venereal disease of cattle caused by a protozoan parasite, Tritrichomonas foetus. The disease has been reported worldwide with an estimated economic loss to the U.S. beef industry exceeding $100 million annually due to reduced conception rates, lowered weaning weight
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A Reduction in Sumoylation of Cellular Proteins Reduces Polyglutamine Toxicity in Vivo in a Drosophila Fruit Fly Model of Huntington's Disease

Background: Huntington's disease (HD) is a fatal, autosomal dominant, progressive neurodegenerative disorder. Clinical symptoms are progressive and include chorea, impaired voluntary movement, behavioral changes and dementia. Present therapies are limited to alleviating these symptoms without any i
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Novel, Stand-alone, Closed Ventilating Circle Circuit with CO2 Absorption and Sensitive Spirometry Measures Pulmonary O2 Uptake During Anesthesia

Background: The volume of O2 consumption (VO2) and the volume of CO2 production (VCO2) can give vital information about a patient under anesthesia. For example, monitoring VO2 can detect non-steady state critical events and changes in tissue metabolism in anesthetized patients. However, no accurate
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New Clinical Bymixer for Fast-Response, Adjustable Measurement of Mixed Expired Gas Fractions in the Anesthesia Circle Circuit

Background: The volume of O2 consumption (VO2) and the volume of CO2 production (VCO2) can give vital information about a patient under anesthesia. For example, monitoring VO2 can detect non-steady state critical events and changes in tissue metabolism in anesthetized patients. However, VO2 and VCO
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Device for Controlling and Limiting Thermal Injury to Tissue During Thermal procedures

Background: Various thermal techniques are under development that generate heat in the nasal septum. One concern related to these procedures is that heating the septum or its component structures (e.g. cartilage, bone, mucous membrane, perichondrium, blood vessel) will result in full thickness inju
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A New Burr Design

Background: One of the great limitations in spine surgery is the difficulty with removing bone without damaging adjacent soft structures (such as the spinal cord, nerves, and durra). This difficulty has significantly restricted the ability to do effective endoscopic surgery around the spine. Shield
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An Antibody-based Method for Reducing Ocular Inflammation which Can Aid in Corneal Transplantation

HSV keratinitis is characterized, in part, by scarring of the eye as a result of HSV reactivation. To date, corneal transplantation is the standard treatment method. A significant obstacle preventing successful corneal transplantation is inflammation that occurs within the eye (ocular inflammation).
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Multi Stage Control Architecture for Error Suppression in Micromachined Gyroscopes

Background: In the past, for micromachined gyroscopes to operate with highest precision required characterization by the manufacturer followed with post processing such as laser trimming, ion beam milling or selective material deposition and integration of feedback control. This process is expensiv
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Microfluidic Devices for Controlled Viscous Shearing and Formation of Amphiphilic Vesicles

Background: Amphiphilic vesicles are artificial cells with applications in drug delivery (including biomolecular nanomedicine such as DNA, peptides, proteins), combinatorial chemistry, nanoscale chemical reaction chambers, biomolecular devices (power, optical, electrical), and various biosensors.
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R6G9 Treatment Improves Viral-Induced Neurological Disease

Background: Multiple Sclerosis (MS) is a devastating neurological disease. MS patients often experience neurologic dysfunction believed to be the result of infiltration of immune cells, inflammation of the central nervous system and eventual nerve damage. Technology: Researchers at the Universit
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Fluorescing Materials for 3D Memory Devices

Background: Photochromic fulgides are capable of reversible light-induced coloration. These organic compounds exhibit several important physical properties such as thermal stability of both colorless and colored forms, high photoreaction efficiency, high fatigue resistance to repeated coloration-bl
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Reagents and Methods for Diagnosis of Attention Deficit Hyperactivity Disorder

Background: Attention Deficit Hyperactivity Disorder (ADHD) is the most prevalent disorder of early childhood. It affects an estimated 3-6% of elementary school children. ADHD consists of developmentally inappropriate inattention, impulsivity, and hyperactivity with early onset (before the age of 7
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Top-Gate Carbon Nanotube Field Effect Transistor

Background: A carbon nanotube (CNT) is a one-dimensional molecular wire which is believed to have many potential applications in upgrading the density and performance of electronic information systems. Technology: This invention solves six potential problems with incorporating CNT's into next ge
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Treatment of Bladder and Urinary Tract Cancers Using Chalcone and Flavone Derivatives

Background: About 56,000 new cases of bladder cancer are diagnosed in the United States each year and approximately 12,000 Americans will die of the disease. Drawbacks of older cisplatin based therapies, such as MVAC, include toxicity and poor patient tolerance. Newer therapies such as paclitaxel d
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High-Isolation Tunable MEMS Capacitive Switch

Background: For a typical MEMS switch, the resonant frequency is around 20 to 30 GHz which can not be employed by commercial wireless systems operating at a frequency band of 2 to 8 GHz. This resonant frequency can be tuned by changing the inductance of the switch membrane. When inductance is incre
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New Protein Resistant and Biodegradable Biopolymer

Background: The ability to resist nonspecific protein adsorption (protein resistance) is an indicator of a material's biological inertness or biocompatibility. Protein resistant biomaterials such as the commonly used poly(ethylene glycol) (PEG) have been used in a number of applications such as pro
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Photonic Slab with Axially Frozen Mode

Background: A unidirectional gyrotropic photonic crystal allows electromagnetic wave propagation in a certain direction at a certain frequency and at the same time, impedes electromagnetic wave propagation in the opposite direction. The electromagnetic wave with impeded propagation, called the "fro
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Method for Quantitative Digital Color Imaging of Objects

Background: In many disciplines, quantitative measurements of color are required to evaluate nondestructively the state of an object (e.g., quality of produce). This characterization is typically performed using contact point measurement devices. A limitation of these devices is that multiple measu
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Design and Synthesis of PET Radioligands for alpha 4 beta 2 Nicotinic Acetylcholine Receptors

Background: Nicotinic acetylcholine receptors (nAChRs) belong to the superfamily of ligand-gated ion channels and are distributed widely in the human and nonhuman brain. Several nAChRs have been identified and characterized pharmacologically and have distinct patterns of distribution in the brain.
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Broadband Distributed-Mass Micromachined Gyroscope

University researchers have invented a distributed-mass micromachined gyroscope which minimizes quadrature error, eliminates effects of directional residual stresses, and completely decouples the drive and sense modes. The device has multiple drive-mode oscillators, distributed symmetrically around
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Melanin Concentrating Hormone Receptor Small Molecule Antagonists for the Treatment of Obesity and Related Metabolic Disorders

In mammals, Melanin Concentrating Hormone (MCH), a GPCR, has been shown to regulate food consumption and energy metabolism. Central administration of MCH has been shown to promote feeding while mRNA levels of the MCH Receptor 1 (MCHR1) rise as a result of starvation and leptin deficiency. MCH also s
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Nickel Diimine Cyclophane Catalysts for High Temperature Gas Phase Olefin Polymerization

Late transition metal olefin polymerization catalysts have received much attention recently because they can produce polyolefins with interesting new branching topologies and have better tolerance to functional groups. The PdII and NiII alpha diimine complexes are such catalysts, however they respec
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Neuropeptide S (NPS) as a Treatment for Anxiety, Sleep Disorders, Attention Deficit Hyperactivity Disorder, Attention Deficit Disorder, and Asthma

Background: Patent "WO02/31145" discloses a newly deorphanized GPCR system, Neuropeptide S (NPS), the endogenous ligand, and its cognate GPCR. However this patent does not detail the pharmacological or physiological function of NPS and its GPCR. University of California, Irvine researchers have cha
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Methods for Treating Port Wine Stain Birth Marks, Hemangiomas and Other Conditions Caused By Aberrant Blood Vessels

Background: Cutaneous vascular lesions including port wine stains (PWS) and hemangiomas are frequently treated with laser and light devices. The pulsed dye laser (PDL) is the current standard means of treatment care for PWS and achieves effect by selectively targeting tissue vasculature. However, f
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Using Female Endocrine Hormones to Improve Psoriasis

Background: The most commonly prescribed medications for severe psoriasis are methotrexate and cyclosporine. Both these medications have serious side effects. The next line of treatment includes phototherapy but this is limited by the availability of light boxes in the dermatologist's office. Biolo
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Optimal Spatial Sub-channel Resources Allocation Mechanism for Sustainable Bit Rate Wireless Conduits

Background: The latest video compression standard (MPEG-4) has moved the wireless industry one step closer to the world of high quality multimedia services. Commercial wireless MPEG-4 video codec systems can already support up to Level 3 of the MPEG Simple Visual Profile. However, the issue of how
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