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Polymeric Valves for Controlled Drug Delivery
Background: Biochips can be used in vitro or in vivo to deliver small, controlled amounts of chemicals or other molecules at controlled times and rates. Current delivery release mechanisms include electrochemical dissolution of thin anode membranes covering microreservoirs filled with drug. The met
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Fuel Cell System for Aircraft Propulsion
Background: Aircraft thrust is traditionally come from a combustion engine (internal combustion or gas turbine) coupled to either a propeller or a nozzle to produce thrust. These systems deliver high performance but also have high emissions and low fuel efficiency. Some proposals have used fuel cel
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Microfluidic Flow Transducer Based on the Measurement of Electrical Admittance
Background: The development of multifunctional, high throughput lab-on-a-chip depends heavily on the ability to measure flow rate and perform quantitative analysis of fluids in minute volumes. Traditionally, there have been many microelectromechanical system (MEMS) based flow sensors for gaseous fl
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Immunoassay Apparatus and Method Using Flow Induced Electrical Admittance
Background: There remains a need for new immunoassay techniques and related devices for performing immunoassays with improved simplicity, efficiency and/or accuracy. The present invention provides for a new immunoassay method, namely, a flow induced electrical admittance immunoassay (FIEAI). This p
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A Microfluidic Dynamic Vapor Control System
Background: Controlling the chemistry of small drops is troublesome owing to the difficulty in handling and metering small volumes. To change the chemistry of a 50nl drop by 10% would require adding or removing a 5nl quantity - very difficult. As a result, most nanovolume assays are set up once and
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Automatic Detection and Diagnostics of Diabetic Retinopathy
Background: Diabetes is a condition that affects blood vessels throughout the body, particularly in the kidneys and eyes. Diabetic retinopathy is a complication of diabetes and is the leading cause of new blindness in the United States. Diabetic retinopathy results when diabetes affects vessels in
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A Broadband Amplifier with Huge Gain-bandwidth Product and Low Power Consumption
Background: Without a distributed amplifier, most broadband amplifier bandwidths can be achieved around 1/10 to 1/3 of their fT only. Therefore, a high bandwidth amplifier requires high fT (at least 3-10 times of the amplifier bandwidth) transistors in order to achieve high bandwidth. Unfortunately
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Antibodies that Bind and Detect Acute Lesions in MS Brains
Background: In patients suffering from multiple sclerosis (MS) B cells, stimulated by axon antigens, infiltrate central nervous system. Technology: The inventors discovered a new class of antibodies that specifically binds to axons in early stage of acute lesions in multiple sclerosis (MS) brain
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Regulated Growth Factor Delivery for Nerve Regeneration
Background: Options for successful repair of peripheral nerves after traumatic injury remain suboptimal. Current strategies are limited to transfer of donor nerves from functional areas, with substantial donor-site morbidity and variable outcomes. The development of tissue-engineering strategies of
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Composite Transistors for Compensation of HBT Self-heating Effect and Enhancement of HBT Linearity
Background: Heterojunction bipolar transistors (HBT's) are the key components in the high output power densities circuits at microwave frequencies and are increasingly being utilized for large signal applications such as power amplifiers, oscillators, and mixers. These high power densities in HBT c
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Invention of New Dendritic Amphiphiles
Background: Amphiphilic compounds are of general interest in numerous disciplines in life sciences, especially in pharmacology and general chemistry, and numerous amphiphilic compounds are known in the art. However, traditional amphiphilic compounds usually forms micelles or aggregates that are oft
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Nrf1 Deficient Mice as a Model for Liver Cancer and Non-Alcoholic Steatohepatitis
Background: Antioxidant and xenobiotic metabolizing enzymes are critical in the protection against chemically induced oxidative/electrophilic stress in cells that cause damage, DNA mutation, apoptosis, and cancer. Transcription of these cytoprotective genes and xenobiotic metabolizing genes is regu
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Use of Laser-Induced Fluorescence for Determination of Root Canal Pathology and Localization of Pathological Tissues to Facilitate Endodontic Therapy
Background: Currently endodontic therapy is based upon radiographic information and tactile feedback. Direct detection and localization of infected dentin and pupal tissue has not been possible. It has been determined that when excited at appropriate wavelengths of light, the fluorescence emission
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Somatic Mitochondrial DNA (mtDNA) Control Region (CR) Mutations Associated with Alzheimer's Disease: the Cause and Diagnosis
Background: Sporadic Alzheimer's Disease (AD) has been associated with defects in mitochondrial oxidative phosphorylation (OXPHOS) as well as inherited and somatic mitochondrial DNA (mtDNA) mutations. To determine if mtDNA mutations contribute more generally to the etiology of AD, we have investiga
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A Diffusive Probe for Quantification of Optical Properties of Superficial Layers
Background: Diffuse optical spectroscopy (DOS) has been successfully employed for quantitative determination of in vivo optical properties and chromophore concentrations of deep tissues such as breast and brain. This invention is a method and probe design for obtaining quantitative optical properti
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Torsional Z-axis Surface-Micromachined Gyroscope
Background: The limited thickness of structural layers attained in current surface-micromachining processes results in very small sensing capacitances and higher actuation voltages, restricting the performance of the surface-micromachined gyroscopes. Technology: University researchers have devel
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Post-Release Capacitance Enhancement in Micromachined Devices
Background: Capacitive detection and actuation are commonly used in micromachined devices due to simplicity of implementation and effectiveness. However, the performance of capacitive sensors and actuators highly depends on the nominal capacitance of the microsystem. For example, in capacitive micr
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Cell Encapsulation on a Microfluidic Platform
Background: Cell encapsulation is a highly useful tool in cell culturing, assay, and cell-based therapy applications. Encapsulation has traditionally been accomplished by extrusion through a nozzle, forming an air/water emulsion, into a bath containing a polymerizing agent. However, this batch proc
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Fluoro-Free Guidewire for Improved Colonscope
Background: Endoscopes with a soft insertion unit can be inserted into the lumen of a body cavity to diagnose problems located in a deep region in the body cavity without the necessity of incision and can also be used to guide treatment appliances to a desired location within the body cavity. In th
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Method of Fabrication of Self-enclosed Microchannels and/or Chambers with or Without Integrated Interconnects and Electrodes
Background: Conventional methods that create fluidic channels using photopolymers create channels and chambers by-coating, patterning, and developing each layer sequentially. These conventional methods of fabricating microchannels also involve using molds or patterning channels onto a flat substrat
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New Polymeric Biomaterials
Technology: The invention is on new polymeric biomaterials. The new biomaterials were created by chemical synthesis with carbohydrates and amino acids as building blocks. The biopolymers have a specific alternating structure between carbohydrate and peptide units. Application: The new biomateria
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Selective Inhibitors of Monoacylglycerol Lipase as a Treatment for Neurological Disorders
Background: Acute stress elicits the rapid formation of two endocanabinoid ligands, 2-arachidonoylglycerol (2-AG) and anandamide (AEA). These endogenous lipids bind to the CB1 cannabinoid receptor and inhibit pain sensation by acting as non-opioid stress-induced analgesics. AEA and 2-AG are metabol
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Transgenic Mouse Model for Screening Analgesic Agents
Background: UC Case No.: 2004-692 Patent Application Publication No.: WO/2006/017293 International Application No.: PCT/US2005/024697
This invention is an animal model and various cell-based models to determine nociception, pain transduction, and pain threshold.
Researchers at the University
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A New Tandem-Affinity Tag for Two-Step Protein Purification under Fully Denaturing Conditions
Background: Preservation of posttranslational modifications during purification is crucial for successful mass spectrometric analyses of protein modifications. Current tandem-affinity purification strategies require native conditions and are therefore susceptible to loss of posttranslational modifi
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Humid Air Turbine - Combined Cycle Hybrid
Background: The Humid Air Turbine (HAT) cycle is an intercooled gas turbine-based cycle which utilizes generation of water vapor by directly contacting pressurized air leaving a compressor of the gas turbine with hot water in a counter-current humidifier and circulating the water leaving the humidi
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Microscope Immersion Fluid Applicator
Background: Microscopy is an important tool used by all researchers in the scientific community. Often, a microscope user will first scan the specimen with a low power dry objective and then wish to switch to an oil, water or glycerin immersion objective to increase optical resolution. In other cas
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New Multiphase LLC Resonant Voltage Regulators for Next Generation Microprocessors
Background: Recent developments in semiconductor manufacturing technology have resulted in unprecedented density of transistor elements per silicon area. This new technology facilitates a dramatic increase in circuit complexity of the modern computer and communication hardware. With transistors dim
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Methods for Making 2D Nanoscale PN Junctions and Junction Arrays
Background: Silicon-based device structures capable of laser emission are highly desirable since they allow realization of integrated opto-electronic circuits. Unfortunately, it is generally believed that silicon's inherent bandgap prevents its use, alone, as lasing media. Numerous approaches to ov
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Methods for Assessing the Temperature of Deep Tissue in vivo Using Non-ionizing Radiation
Background: Measuring temperature in tissue is highly relevant to treatments applied to tissue in which the tissue becomes heated. This includes methods that treat tissue with RF (Radio Frequency) such as radio frequency ablation of cancer, hyperthermia treatments of cancers and cosmetic skin treat
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Total Ankle Arthroplasty
Background: Total ankle arthroplasty (TAA) is the process of replacing a diseased ankle with a prosthetic ankle. Over the years there have been several efforts to provide a total ankle replacement solution. However, all such current solutions have significant drawbacks, including complications relat
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Method to Characterize Exhaled Nitric Oxide from the Airways Using a Sequence of Breathhold Maneuvers
Background: Exhaled nitric oxide (NO) arises from both airway and alveolar regions of the lungs, which provides an opportunity to characterize region-specific inflammation. Current methodologies rely on vital capacity breathing maneuvers and controlled exhalation flow rates, which can be difficult
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Fabrication of Suspended Carbon Micro and Nano-scale Structures
Recent attention has focused on high aspect ratio carbon micro-electromechanical (C-MEMS) because of the many applications possible, such as micro-electrodes in electromechanical sensors and miniaturized energy storage/energy conversion devices. Further, suspended micro/nano carbon structures exhibi
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Rapid Bio-Molecules Detection by Adjacent Impedance Probing (AIP) Techniques
Background: Today, most detection schemes for DNA, proteins and other large biomolecules involve luminescent measurements using a variety of labels (i.e. fluorescent and/or chemiluminescent probes, photoproteins, etc.) and the binding of these large molecules to their complementary molecular struct
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Method and Apparatus of Using 3D Conductive Structures in Dielectrophoretic Separation Applications
Background: Researchers estimate that 80% of all machine failures are due to wear and that 1.3~1.6% of the GNP is lost to degradation of machinery due to friction-related wear. The abnormal abrasive wear due to lubricant contamination in marine diesel engines eclipses that of normal wear and the ga
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Efficient Transaction Based Modeling with Cycle Count Accurate at Transaction Boundary (CCATB) Models
Background: In the past, several modeling abstraction levels were proposed to improve simulation speed and modeling time over detailed cycle accurate (CA) models. The Pin Accurate Bus Cycle Accurate (PA-BCA) modeling abstraction maintained cycle accuracy at every cycle boundary for communication in
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Glycosylase enzymes
DOMAIN Glycosylases have found use in a number of methods aimed at analyzing DNA for the presence of altered nucleobases that could result from ionizing radiation or chemical oxidants, identifying mismatched base pairs, studying repair of abasic sites in double-stranded DNA and as a means to prevent
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Determining leakage through a heart valve
Determining the severity of a leakage through a heart valve is important. There are several parameters that are clinically interesting in this regard: the area of the lesion, the flow or flow rate through the lesion and the geometry of the lesion. These three parameters are not easy to measure. Curr
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Applications of Photonic Crystals with Degenerate Spectral Band Edge
In a vacuum, light propagates with a constant velocity, while in an optically transparent non-dispersive media, the speed of light propagation can be different. At optical frequencies, the refractive index of transparent materials usually does not exceed several units, and the speed of light propaga
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High Density Micromachined Electrode Arrays Usable for Auditory Nerve Implants and Related Methods
Background: Auditory prostheses using microelectrode arrays suffer from a number of limitations. Issues that were not resolved are electrode size, the need for electrical wires to communicate with and transfer power to the arrays, and the need for hand assembly of the devices. Technology: Resear
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Phage-displayed Peptide Library with Affinity for Bacterial Elongation Factor Tu
Background: The highly abundant GTP binding protein elongation factor Tu (EF-Tu) fulfills multiple roles in bacterial protein biosynthesis. EF-Tu also binds other ligands, including four structurally distinct families of antibiotics. The lack of sequence homology among the identified EF-Tu ligands
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Environmentally-Sensitive Reconfigurable Antenna
Background: With the exception of light-based sensors, that change their light interaction properties, all sensors require some power in order to operate and provide a signal to a remote source. Light-based systems are readily blocked by typical obstructions such as buildings, trees, and vegetation
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MEMRI (manganese enhanced MRI)
DOMAIN Within an ageing population, ischemic heart disease (IHD) and secondary heart failure represent major challenges underlining a demand for diagnostic imaging to identify IHD in its different stages and forms. There is also a need to diagnose heart failure developing after myocardial infarction
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Methods and Compostions for the Treatment of Immune Disorders and Regulation of Cytokine and Growth Factor Signaling
Categories: Pharmaceuticals: Central Nervous System Disorders, Immune and Inflammatory Disorders Biotechnology: Assays, Diagnostics, Model Systems
Background: Mgat5 is an enzyme that glycosylates T-cell receptors to modulate T-cell activation and autoimmune response. Mgat5 Null PL/J Mice were
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Methods of Improving Memory and Cognition
Technology: University of California, Irvine researchers have discovered a new method of improving memory by selectively modulating nuclear receptor cell signaling. The technology has been validated in several animal models of memory in both rats and mice. Application: This technology provides a
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ThirdEye – early detection of cerebral palsy (CP)
DOMAIN An early and accurate detection of cerebral palsy (CP) enables correct treatment at an early age to the infant at risk. Today’s methods for detecting CP are unable to establish a diagnosis until late in the first year of life, in some cases even later. Experts are currently doing analysis of
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A New PET Radiotracer for Serotonin 5HT1A Receptors
Background: Serotonin 5-HT1A receptors are implicated in Alzheimers disease, dementia, anxiety, schizophrenia, and depression, and significant efforts have been undertaken to develop various compounds that bind to these receptors for potential use in diagnosis and therapy of disorders associated wi
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Fiber optic bundle based optical coherence tomography
Background: Optical coherence tomography (OCT) has been used for high resolution optical imaging in many areas of medicine, especially ophthalmology. "Conventional wisdom" was that OCT could not be done through flexible fiber bundles. Indeed, the use of flexible fiberoptic bundles to deliver OCT di
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Real time hyperspectral imaging
In many situations it would be beneficial to have an instrument that can show directly the spatial distribution of various chemical components in real time of a surface. Typical application areas are forensic and military where investigators can rapidly locate the presence of blood, gunpowder, toxic
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Broadband Power Amplifier with a Novel Tunable Output Matching Network
Background: In the past decade, InGaP/GaAs heterojunction bipolar transistors (HBTs) have been the key technology in delivering solutions for both high efficiency and high linearity monolithic microwave integrated circuit (MMIC) power amplifiers in various wireless communication systems, such as GS
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SENSE-optimized MRI RF Coil Design with Target Field Method
Background: In the past, people have used general-purpose MRI RF coil structures, which were not optimized for accelerated SENSE imaging technique. Therefore, SNR (signal-to-noise ratio) was not maximized for this particular technique. Several researchers have tested several basic RF coil designs a
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Optimal selection of flurophores for bioimaging using hyperspectral cameras
DOMAIN In many situations it would be beneficial to have an instrument that can show In biology and medicine, fluorescent labelling is used to detect the location and concentration of various molecules. This can be used to discover how molecules are interacting in relation to diseases and biological
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Wall-Less Microfluidics with On-Site Magnetohydrodynamic (MHD) Pumps for Continuous Flow Control
Background: A disadvantage of closed microfluidic channels are that they are made from different materials. Also, most of the microchannels are fabricated from lithography techniques which require the utilization of cleanroom environments, increasing the fabrication costs. Another disadvantage of t
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A Microfabrication Process for Vertical Microelectrodes inside Polymer Microchannels
Background: For microfluidic applications, different electrodes inside the microfluidic channels may be patterned by metal evaporation methods such as thermal evaporation, electric beam evaporation, and sputtering. Since most of the deposition methods only deposit very thin layers of metal (e.g., u
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Rapid prediction of gene expression levels using spectroscopy
DOMAIN The study of gene expression in cells is increasingly being used to understand their biological function. The genes are up- and down-regulated by a complex protein regulatory network, which responds to the biochemical changes originating from within and outside the cell. One of the most popul
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Alginate - Drug Delivery System
DOMAIN The mucosal surfaces of the body (such as GI tract, respiratory tract, eye, and genitourinary tract) constitute the major target for drug and gene delivery. As such, mucous secretions can have a significant influence on drug/gene complex uptake. These effects of mucus are usually more pronoun
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Diagnosis and prognosis of cancers in GI tract
DOMAIN Although the incidence of gastric carcinoma (tumour in stomach) is declining, this disease is still the second most frequent cause of cancer death worldwide. Gastric carcinomas are often not detected until at an advanced stage; consequently, the 5-year survival rates are low and most often in
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Medical Spectroscopy
DOMAIN Aging of injuries on a victim’s body is an important aspect of forensic medicine. Currently, visual assessment and colorimetry based on empirical criteria are the most common techniques for this task, although the results are uncertain. The aim of this study was to develop a mathematical mode
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New Therapy to Inhibit Plasma Cells in Autoimmune Diseases
Background: In patients suffering from multiple sclerosis (MS) B cells, stimulated by axon antigens, infiltrate central nervous system. Technology: The inventors discovered a new class of antibodies that specifically binds to axons in early stage of acute lesions in multiple sclerosis (MS) brain
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Microfluidic Production of Monodispersed Submicron EmulsionsThrough Filtration and Sorting of Satellite Drops
Background: In the past decade, droplets have been intensively used by the industries as an agent for drug preparations, for plastic polymerizations, and chemical processing. Recent advancements in microfluidic droplet technology has enabled the precise sampling and processing of small volumes of f
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Rapid Multiplex Gene and mRNA Detection in Picoliter Droplets by Molecular Beacons
Background: Breast cancer is a world wide public health concern and the estimated death toll in the U.S. in 2001 was 20,000 and it also ranked first as the cause of cancer death for women between the ages of 20 to 59. People carrying a mutation in the BRCA1and BRCA2 genes are prone to breast cancer
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Formulation of Monodisperse Contrast Agents in Microfluidic Systems for Ultrasonic Imaging
Background: Ultrasound imaging may be used to produce a 2D image of the body's internal structures. However, since blood is much less (1000x less) echogenic than tissue, small vessels, blood pool volume and blood flow all are difficult, if not impossible, to image using traditional ultrasound techn
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Treatment of Retinal Disorders by Transforming Growth Factor-Beta (TFG-beta ) Superfamily Proteins and their Antagonists
Background: Retinal disorders often turn into debilitating diseases, and in most cases only few treatment options are available. With available treatment options, vision is usually not restored and treatments are often limited to delaying disease progression. Recent developments using implanted dev
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Use of Optical Coherence Tomography (OCT) for Use of Comprehensive Intra-oral Diagnosis
Background: In dentistry there exists a pressing need for novel diagnostic modalities. A strong consensus for reducing patient exposure to ionizing radiation is countered by the absence of other non-invasive diagnostic and monitoring tools. Diagnostic options for soft tissue pathologies are also li
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Purification of Laminin 5
Background: Lamin-5, a protein produced by skin, mammary and other epithelial cells, may be involved in the progression of cancer. Purified human laminin-5 is not commercially available, and we have developed a purification procedure that may make it more available to the research community. Tech
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LEF-1 Internal Ribosome Entry Site
Background: Full length Lymphoid Enhancer Factor-1 (LEF-1) is a transcription factor that promotes cell growth via its interaction with the WNT signaling mediator beta-catenin. Truncated LEF-1 lacks the beta-catenin binding domain and opposes WNT signaling as a competitive inhibitor for WNT respons
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Biomarker-Guided Prediction of Patient Adherence to Medications
Background: Adherence is one of the pivotal determinants of treatment outcomes for many medical disorders. It is estimated that 50% or more of patients with chronic conditions are noncompliant with medications at some time during their illness. Although there have been numerous attempts to develop
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Single-Mask Fabrication Process for Linear and Angular Piezoresistive Accelerometers
Background: Piezoresistive accelerometers are traditionally fabricated by doping selected areas of wafer to achieve isolated pn-junctions. Often, two separate doping steps are employed to obtain both highly-doped conductors as well as lightly-doped piezoresistors. Once the piezoresistors and conduc
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A Microfluidic Device for Enabling the Controlled Growth of Cells and Methods Relating to Same
Background: In many neurodegenerative diseases and in spinal cord injury, axons and synapses are damaged; a cell culture model is useful for investigation into these areas of research. In typical cell culture it is difficult to distinguish axon from dendrite, and fairly impossible to simulate micro
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Fabrication of Renewable RNA Microarrays and Methods
Background: Numerous methods and devices are available to detect and/or quantify target DNA in a test sample. In almost all of these methods, detection and/or quantification are performed utilizing a detectable label such as radiolabels, fluorescent and luminescent labels. Methodologies employing l
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Methods and Reagents for Screening New Drugs and Treating Ion Pump Associated Disorders
Background: Sodium/potassium ATPases (Na+/K+-ATPases), a family of multi-subunit ion pumps, are the most important active transporters in animal cells. They are required for maintaining the electrochemical gradient responsible for resting membrane potentials in neuronal cells and for the function o
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Advanced Materials Processing
Background: Materials with a grain size smaller than one micron, and larger than a nanometer, are known as ultra-fine grained materials. Ultra-fine grained materials are attracting considerable amounts of interest primarily due to their superior properties in strength, ductility, formability, fatig
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Novel Successive Beamforming Schemes for Multiple Antenna Systems
Background: A new trend in wireless communications is to use multiple transmit and receive antennas such as those found in MIMO wireless systems, to attain higher data rate, better signal quality, and superior system flexibility. Transmit beamforming has been widely adopted for wireless systems wit
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Successive Transmit Beamforming Algorithms for Multiple-Antenna OFDM Systems
Background: In this paper, we focus on the design and evaluation of new transmit beamforming algorithms for the multiple-input single-output (MISO) orthogonal frequency division multiplexing (OFDM) systems. The OFDM technique is very effective in combating frequency selective fading since it conver
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Universal Gain Cells for Broadband Amplifiers
Background: Designing distributed amplifiers by using heterojunction bipolar transistors (HBTs) is a great challenge compared with using field effect transistors. The reasons causing this challenge are a) the input capacitance, C?, of HBT is typically an order of magnitude larger than input capacit
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Development of Diagnostics and Therapeutics for Cornelia de Lange Syndrome
Background: Cornelia de Lange Syndrome (CdLS) is a moderately common multisystem birth defects disorder that poses severe medical and social challenges for affected children and their families. Diagnosis of Cornelia de Lange Syndrome (CdLS) is based on clinical signs, including abnormal upper limbs
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Generation of Stable Concentration Gradients in 2D and 3D Environments Using a Microfluidic Ladder Chamber
Background: In the chemical, biomedical, and pharmaceutical industries, it has become increasingly desirable to perform large numbers of chemical operations in a highly parallel fashion. For example, cell culture methods are a commonly used research techniques that allows the systematic manipulatio
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Wafer-Level Micro-Glass Blowing
Background: Large scale confinement chambers have been created in the past using traditional glass-blowing techniques. However, conventional glass-blowing can only be used to create large components and requires the components to be made one at a time. Micro-glass spheres have previously been fabri
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Transmit Beamforming for a Large Reconfigurable Antenna Array
Background: Many space-time transmission schemes have been proposed recently to exploit the high channel capacity of MIMO communication systems. However, algorithms for a large antenna array (LAA) remain an open research problem. The standard channel estimation and space-time modulation schemes are
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Real-Time Electrochemical Detection of Targets Using Phage-Displayed Polypeptides
Background: With up to 10^12 unique members, phage-displayed libraries provide a vast pool of candidate receptors to essentially any target. Despite this tremendous potential of phage-displayed libraries for universal molecular recognition, the technique has found only limited application in biosen
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A Method and Apparatus to Inactivate Stem Cell Nuclei
Background: Stem cells may hold the key to future cures for many diseases. These are embryonic cells that are thought to have the potential to develop in any kind of tissue: liver, kidney, brain, etc. There is great scientific, medical, and economic interest in any technology that can facilitate th
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Portable Load Monitoring Device for a Patient"s Foot
Background: Subsequent to a variety of medical procedures including, but not limited to knee arthroplasties, hip arthroplasties, and fracture repairs, post-operative weight-bearing on the affected leg must be limited to facilitate proper healing and avoid exacerbation of injury. However, some degre
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Distributed RF Front-End for UWB Receivers
Background: Ultra-Wide Band (UWB) wireless broadcasts are capable of carrying huge amounts of data up to 250 feet with extremely little transmit power and high immunity to interference and multipath fading. The spread spectrum characteristics of UWB wireless systems, and the ability of UWB wireless
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Novel Distributed Direct Conversion Receiver for UWB Systems
Ultra-Wide Band (UWB) wireless broadcasts are capable of carrying huge amounts of data up to 250 feet with extremely little transmit power and high immunity to interference and multipath fading. The spread spectrum characteristics of UWB wireless systems, and the ability of UWB wireless receivers to
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Six-Bar Rear Bicycle Suspension
Background: Current bicycle rear suspension designs cannot ensure that the axle of the rear wheel follows a circle around the bottom bracket that holds the pedal wheel axle. This means that pedal forces cause the suspension to deflect, which wastes rider energy. Technology: University researcher
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Hybrid Binding Proteins Against Pathological Protein Aggregates in the Central
Background: The pathological protein aggregates such as beta-amyloids, alpha-synuclein and prion protein deposits in the CNS can be removed by vaccination, i.e., immunization using specific antibodies andlor synthesized antigens. Studies have demonstrated that clearance of these pathological protei
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Protein Nanocapsule for Drug Delivery
Technology: University of California researchers are investigating a protein scaffold system for molecular transport, namely, the E2 protein of Bacillus stearothermophilus in the pyruvate dehydrogenase complex. This model system has many features that make it attractive as a generalizable scaffold
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An Integrated Microfluidic Platform with Lateral Dielectrophoresis (DEP) Based Cell/Particle Separation
Background: Most of the current techniques used for Dielectrophoresis separation use planar electrodes which sit at the bottom of the channel. With this design the electric field decreases dramatically as the height increases. Correspondingly, the gradient of the electric filed which is denoted as
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Non-scattering Oxygen Carrying Media for Intravascular Optical Coherence Tomography Imaging
Background: If blood is replaced locally in the vascular system by injection of saline solutions, OCT images can be obtained for brief periods of time, but lack of oxygen is deleterious to the tissues, and ischemia and damage will result, compromising patient health, as well as the OCT images obtai
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Trace-Driven, Just-In-Time Compilation with a New Application of Static Single Assignment Form
Background: A decade after Java arrived, there have been improvements in the runtime performance of platform-independent virtual-machine based software. However, using such machine-independent software on resource-constrained devices such as mobile phones and PDAs remains a challenge, as both inter
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High-Velocity, Ion-Driven Wind Generator
Background: A fluid can be accelerated to high velocities using electrostatic forces and no moving parts. This concept, termed "ion-driven", "ionic", "Chattock", "electrohydrodynamic", "electrokinetic" or "corona" wind, has been known for over a hundred years. However, only a few meters per second
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A Platform for Seamless Multi-device Interactive Digital Content
Background: Previous mechanisms for connecting two or more devices in the same physical space have been cumbersome, and offered little advantage over connecting two devices that are hundreds of miles apart. There are two general methods: first, the automatic triggering of content when a device ente
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Wafer Scale Glass Blowing
Background: Large scale confinement chambers have been created in the past using traditional glass-blowing techniques. However, conventional glass-blowing can only be used to create large components and requires the components to be made one at a time. Micro-glass spheres have previously been fabri
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A Novel 7 Base Deletion in the Gene on Chromosome 21 for Diagnostic of Keratoconus
Background: Keratoconus is a noninflammatory progressive corneal thinning disorder leading to mixed myopic and irregular astigmatism and is implicated as a major cause of cornea transplants in the Western world. Genetic factors have been suggested as a cause of keratoconus. The stromal thinning of
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Methodology of Elasto-Mammography
Background: It has been well recognized that the tissue stiffness plays an important role for diagnosis of breast cancers, as tumors are stiffer than the surrounding breast tissues, and malignant tumors are much stiffer than benign ones. In other words, in vivo identification of the elastic moduli
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Methodology of Elasto-Mammography
Background: It has been well recognized that the tissue stiffness plays an important role for diagnosis of breast cancers, as tumors are stiffer than the surrounding breast tissues, and malignant tumors are much stiffer than benign ones. In other words, in vivo identification of the elastic moduli
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Asymmetric Clustered Processor Architecture based on Value Content
Background: Most conventional clustered processor architectures are symmetric systems. It is known that the scalability of ahigh-performance processor architecture has been limited in new system designs by various factors, including increasing clock frequencies, issue widths, and greater wire delay
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Technique to Characterize NIitric Oxide Exchange in the Lungs
Background: It has been reported that the concentration of Nitric oxide (NO) in the exhaled breath was substantially elevated in patients with asthma who were not treated with corticosteroids, suggesting that exhaled NO was a potential noninvasive index of assessing lung and airway inflammation. Be
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Microfluidic Device for Forming Monodisperse Lipoplexes
Background: The determinant factor for the successful applications of delivering drugs is to develop a non-viral and efficient carrier. Cationic lipid based liposomal carriers are the most attractive non-viral solution. Advantages of liposomal vectors include safety, lack of immunogenicity, ability
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Intragastric Balloon for Treatment of Obesity
Background: The BioEnterics Intragastric Balloon System™ is a non-surgical, non-pharmaceutical alternative for the treatment of obesity. The balloon system is designed to provide loss therapy to reduce health risks related to obesity or risks prior to vital supervised weight loss program. Endoscopi
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Flexible Endoscopic Tube
Background: In performing, through an anatomical channel inside the body, a diagnostic or surgical procedure, the surgeon or operator may need to rotate with precision the distal end inside the body, from the proximal end outside the body. Precise transfer of angular rotation from the proximal to t
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