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Hand-held Electrical Stimulation Device
Apparatuses and methods for the safe and efficient electrical stimulation of tissue. The apparatuses of the present invention are preferably hand-held and are capable of providing electrical waveforms that are effective in promoting wound healing, improving circulation, stimulating peripheral nerves
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Method for Producing a Magnetic Resonance Image of an Object Having a Short T2 Relaxation Time
A method for producing a magnetic resonance image using an ultra-short echo time. The method includes applying a pulse sequence to an object, detecting a spirally encoded and phase encoded magnetic resonance signal associated with the object, and reconstructing the magnetic resonance image based on
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Sensor and System to Detect Bridge Scour
A system for detecting scour associated with a structure having a part thereof extending into a bed of material located under a body of water is provided. The system comprises a sensor unit buried in a portion of the bed of material located in proximity to the part. The sensor unit is structured to
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Method for Diagnosing Renal Diseases Or Predispositions
The invention provides a method of diagnosing a disease or a predisposition to contract a disease by assaying for mutations of uromodulin (UMOD) within a test subject or patient. The presence of a mutation in the UMOD supports a diagnosis of a disease or a predisposition to contract a disease within
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Vinyl Substituted Fatty Acids
Activated fatty acids, pharmaceutical compositions including activated fatty acids, methods for using activated fatty acids to treat a variety of diseases, and methods for preparing activated fatty acids are provided herein.
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Identification of markers in esophageal cancer
Methods for identifying expression of markers indicative of the presence of esophageal, a squamous cell cancer, a squamous cell cancer of the head and neck, colon cancer and melanoma are provided. Also provided are articles of manufacture useful in such methods and compositions containing primers an
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Metodo En Tiempo Real Para Detectar Trastornos Inflamatorios Agudos.
Un método para diagnosticar o monitorear lupus eritematoso sistémico (SLE) en un individuo, el método caracterizado porque comprende: (a) determinar el nivel de un componente de trayectoria del complemento C4d en un reticulocito del individuo y (b) comparar el nivel del componente de trayectoria del
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Anti-hmg Monoclonal Antibodies and Compositions Containing the Same
Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise a vertebrate HMG A box, and an antibody preparation that specifically binds to a vertebr
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Fstl-1 As a Biomaker of Inflammation
The invention provides methods and kits for diagnosing severity of particular types of inflammatory diseases, such as rheumatic diseases, by assessing protein levels of follistatin-like protein 1 (FSTL-1). The level of FSTL-1 protein present in the serum or synovial fluid of individuals suspected of
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Muscle Derived Cells (mdcs) for Promoting and Enhancing Nerve Repair and Regeneration
The present invention describes methods involving the use of muscle derived cells (MDCs), preferably obtained from skeletal muscle, to support the innervation and repair of damaged tissues and organs, particularly associated with nerve damage or neuropathy. The invention relates to MDCs for use in m
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Cortical Control of a Prosthetic Device
A methodology for using cortical signals to control a multi jointed prosthetic device for direct real-time interaction with the physical environment, including improved methods for calibration and training.
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Constitutive Androstane Receptor (car) As a Therapeutic Target for Obesity and Type Two Diabetes
The invention provides a method of controlling obesity or type two diabetes in a human. In accordance with the inventive method, the constitutive androstane receptor (CAR) is agonized within the human, which effectively controls obesity or type two diabetes.
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Prediction and Prevention of Preeclampsia
The present disclosure relates to methods for assessing increased risk of preeclampsia in a pregnant woman. The methods described herein employ measuring relaxin levels, and optionally measuring C-reactive protein levels in a biological sample of a pregnant woman. The disclosure further encompasses
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Biologic Scaffold for Prevention of Pulmonary Fibrosis
Provided herein are methods of preventing, lessening or treating pulmonary fibrosis in a subject. The methods comprise delivering an amount of a powdered extracellular matrix (ECM)-derived material to the respiratory system of the subject effective to prevent, lessen or treat pulmonary fibrosis in a
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Linked Myc-max Small Molecule Inhibitors
Provided herein are compounds and compositions for interfering with the association of Myc and Max. These compounds and compositions are useful in methods for inhibiting growth or proliferation of a cell. Methods of inhibiting growth or proliferation of a cell comprise contacting the cell with an am
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Joint Bioscaffolds
Provided herein are compositions and medical devices, and in particular, biodegradable scaffolds capable of repairing and replacing cartilaginous meniscuses. Also provided herein are methods of using scaffolds for treating degenerative tissue disorders. In certain embodiments, such scaffolds can pro
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Small Molecule Inhibitors of Dusp6 and Uses Therefor
Compounds that stimulate fibroblast growth factor production, and thus cell growth are provided. Also provided are compositions comprising the compounds and methods of using the compounds. The compounds can be used to treat wounds, to expand cell populations, such as hematopoietic cells, or to grow
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Articulating Laryngoscope
Articulating laryngoscope to aid in the intubation of patients by providing illumination of the oral cavity and trachea during the process having, for example, 'fingers' with fiber optic lights at the ends and at joints of the fingers, fingers spread open or 'flower' when the device is deployed, gen
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Thermoresponsive, Biodegradable, Elastomeric Material and Uses Therefor
Provided are novel biocompatible copolymers and compositions comprising the copolymers. The copolymers are non-toxic and typically have an LCST below 37 DEG C. Compositions comprising the copolymers can be used for wound treatment, as a cellular growth matrix or niche and for injection into cardiac
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Blood Vessel Segmentation with Three-dimensional Spectral Domain Optical Coherence Tomography
In the context of the early detection and monitoring of eye diseases, such as glaucoma and diabetic retinopathy, the use of optical coherence tomography presents the difficulty, with respect to blood vessel segmentation, of weak visibility of vessel pattern in the OCT fundus image. To address this p
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Use of Targeted Nitroxide Agents in Bone Healing
Provided herein are compositions and related methods useful for accelerating bone healing and growth. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity.
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Real-time X-ray Vision for Healthcare Simulation
A medical procedure training system and method for using is provided. The system includes a sensing system structured to detect the position and motion of a medical device inserted into a simulated body, a processor structured to generate images of the medical device and relevant anatomical structur
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Human Leukocyte Antigen Alleles Associated with Advanced Lung Diseases
The present invention relates to methods and compositions that may be used to predict the risk of an individual, for example a smoker, for developing chronic obstructive pulmonary disease ("COPD"), emphysema or idiopathic pulmonary fibrosis ("IPF"). The invention particularly relates to methods of e
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System for At-home Eye Movement Monitoring
An apparatus for monitoring eye movement in a patient, includes a frame structured to be worn on the head of the patient. An infrared illumination device structured to illuminate an eye of the patient is supported by the frame. A camera structured to capture images of the eye when illuminated by the
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Artificial Cell Constructs for Inducing Immunological Tolerance
The present invention contemplates induction of immunological tolerance thereby providing permanent allograft acceptance. This method obviates the need for a lifelong regimen of immunosuppressive agents which can increase the risk of infection, autoimmunity, and cancer. Immunological tolerance is th
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Estrogen Antagonists As Treatments for Sclerosing Disorders
The present invention relates to methods and compositions for treating a subject suffering from a sclerosing disorder, comprising administering, to the subject, an effective amount of an estrogen receptor antagonist ("ERANT"), wherein said ERANT has essentially no estrogen receptor agonist activity
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Removal of Oxygen from Biological Fluids
A system for reducing the concentration of oxygen in a fluid including red blood cells includes a housing, a plurality of hollow tubes extending within the housing and adapted for flow of the fluid therethrough, wherein each tube includes an inlet and an outlet, and a carrier system that reduces the
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Fatty Acids As Anti-inflammatory Agents
Compounds of formula I and their metabolites are potent mediators of an inflammatory response: (I) where a, b, c, d, e, f, V, W, X, Y, Ra, Ra', Rb, Rb', Rc, and Rc'are defined herein. In particular, the compounds of the invention are candidate therapeutics for treating inflammatory conditions.
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Methods of Treating Disorders Associated with Protein Polymerization
The present invention relates to methods of treatment of clinical disorders associated with protein polymerization comprising administering, to a subject, an effective amount of carbamazepine, oxcarbazepine or another carbamazepine-like compound. It is based, at least in part, on the discovery that,
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Polymer and method for using the polymer for solubilizing nanotubes
A new, non-wrapping approach to solubilize nanotubes, such as carbon nanotubes, in organic and inorganic solvents is provided. In accordance with certain embodiments, carbon nanotube surfaces are functionalized in a non-wrapping fashion by functional conjugated polymers that include functional group
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Recharging Method and Apparatus
The present invention provides apparatus and an associated method for remotely energizing power storage devices. Energization may preferably be effected through the use of RF energy from a base station, ambient energy or ultra-wide band energy. The remote station preferably has at least one antenna
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Method and Software Tool for Designing an Integrated Circuit
A method of designing an integrated circuit for use in an application having standards having a plurality of primitives, wherein each of the primitives has a corresponding response. The method includes generating a macros description of each of the primitives and the response corresponding to each o
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Multiple Antenna Energy Harvesting
Energy harvesting circuits and associated methods are provided that employ multiple antennas to optimize the amount of energy that is harvested while at the same time making efficient use of tag space. In some embodiments, matching networks are chosen in a manner that optimizes the DC energy that is
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Therapeutic and Diagnostic Cloned Mhc-unrestricted Receptor Specific for the Muc1 Tumor Associated Antigen
The invention provides an isolated nucleic acid encoding a receptor, other than an immunoglobulin, wherein the receptor binds to a MUC1 tumor antigen independently of an major histocompatibility complex (MHC). The invention provides a method of activating a signaling pathway and/or killing a cancer
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Ligands Specific for Cannabinoid Receptor Subtype 2
A compound of Formula I: (I) has activity as a cannabinoid receptor antagonist. In Formula 1, R1 is unsubstituted or substituted aryl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted heterocyclyl, unsubstituted or substituted aralkyl, or unsubstituted or substituted heteroaryl;
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Coils for Magnetic Resonance Spectroscopy and Imaging of Human Breast
System(s) and method(s) for magnetic resonance imaging and spectroscopy, and magnetic resonance spectroscopic imaging (MRSI) are provided. A unified heteronuclear coil system includes a volume coil tuned to detect a first nuclei and a butterfly coil tuned to detect a second nuclei for simultaneous d
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Intracorporeal Gas Exchange Devices, Systems and Methods
A system for intracorporeal gas exchange includes a flexible, rotatable shaft; a plurality of axially spaced agitation mechanisms positioned on the rotatable shaft, such that the rotatable shaft can flex between the axially spaced agitation mechanisms; a plurality of hollow gas permeable fibers adap
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Vocal Cord Augmentation Utilizing Muscle-Derived Progenitor Compositions, and Treatments Thereof
The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment vocal cord tissue following introduction (e.g. via injection, transplantation, or implantation) into the vocal cords. Also provided are method
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Lymph Nodes As a Site for Regeneration
Methods of transplanting cells, such as hepatocytes, are presented herein. Such methods are useful for treating liver disease as well as other disorders.
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Cell Line
The invention provides a cell line complementing HSV ICP4, ICP27, and UL55 genes.
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Adipose-derived Stem Cells and Lattices
The present invention provides adipose-derived stem cells and lattices. In one aspect, the present invention provides a lipo-derived stem cell substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The cells can be employed, alone or within biolo
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Methods of Labeling Biological Samples
Methods are provided for labeling specific oxidized proteins. Methods also are provided for determining the oxidation state of a cell. Such methods are useful as diagnostic, therapeutic and screening agents.
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Substance P and Analogs Thereof As a Cancer Immunogenic Composition Adjuvant
Disclosed herein are methods and compositions effective for treating, preventing, and ameliorating cancer that utilize Substance P or Substance P analogs and antigens. Also disclosed are methods for vaccinating a patient against cancer that utilize Substance P or Substance P analogs and antigens.
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Methods and Compositions for Regulating Th2 and Th17 Responses
Methods are provided for treating diseases, such as asthma, inflammatory bowel disease, autoimmune disease and cancers in which IL-6 production by dendritic cells is elevated. Dendritic cell c-Kit signaling is implicated herein in the production of IL-6 and an elevated TH17 response, such as an elev
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Automated Assessment of Optic Nerve Head with Spectral Domain Optical Coherence Tomograph
A fully automated optic nerve head assessment system, based on spectral domain optical coherence tomography, provides essential disc parameters for clinical analysis, early detection, and monitoring of progression.
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Early Prostate Cancer Antigen-2: a Novel Serum Specific Marker for Prostate Cancer Detection
Early Prostate Cancer Antigen-2 (EPCA-2) is a prostate cancer biomarker, newly identified via proteomics-based examination of alterations in nuclear structure. EPCA-2 shows a higher overall specificity than PSA. Thus, an immunoassay based on antibodies against an epitope of EPCA-2 more accurately di
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Cancer Stem Cell Immortalization
The present invention relates to the preparation and use of immortalized cancer stem cells. The immortalized cancer stem cells of the invention may be used in assays to identify anti-cancer compounds as well as molecules critical to carcinogenesis. Further, cancer stem cells may be harvested from a
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Targeting an Hiv-1 Nef-host Cell Kinase Complex
Drug candidates for inhibition of HIV-I replication can target Src family kinases (SFK), such as Hck, that interact with Nef protein of the virus. Compounds characterized by such inhibitory activity were identified via an assay for kinase activity of an SFK in a Nef:SFK complex. Illustrative of inhi
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Ternary Metal Transition Metal Non-oxide Nano-particles, Methods and Applications Thereof
The present invention is related to ternary metal transition metal non-oxide nano-particle compositions, methods for preparing the nano-particles, and applications relating in particular to the use of said nano-particles in dispersions, electrodes and capacitors. The nano-particle compositions of th
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Novel Biosensors for Live Cell Imaging of Intracellular Proteins
This invention is related to the field of imaging intracellular protein processing. Fluorescent probes capable of changing color over time are used to identify and track the synthesis, trafficking, and secretion of intracellular proteins. One such probe useful in this invention is a monomeric multif
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Cytotoxic T Cell Defined Egfr Peptide and an Optimized Derivative Peptide
The invention provides a polypeptide having a sequence of amino acids consisting of IXDFGLAKL (SEQ ID NO: 1), as well as a nucleic acid encoding the polypeptide, vector comprising the nucleic acid, cell comprising the vector, and compositions thereof. The invention also provides a method of inducing
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Method and System for Acquiring Loundness Level Information
The present invention relates to methods for acquiring hearing threshold values in a subject comprising providing a sound to the subject; providing a monitor for monitoring a movement response by the subject; monitoring the movement response by the subject to the sound; and progressively reducing th
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Motion Activated Amplifier
An electronic device that includes a motion activated amplifier structured to receive a first DC signal having a first DC voltage level and output a second DC signal having a second DC voltage level that is greater than the first DC voltage level. The motion activated amplifier includes a motion act
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Compounds for the Treatment of Pathologies Associated with Aging and Degenerative Disorders
The present invention relates to methods of inhibiting one or more signs of aging and/or degenerative disorder in a subject in need of such treatment, which comprise administering, to the subject, an effective amount of one or more of the compounds as set forth herein. "Inhibiting a sign of aging or
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Polypeptides and Uses Thereof
The invention provides a polypeptide having a sequence comprising from 10 to 24 consecutive amino acids from residues 215-233 of the sequence of human cyclin B1 protein or homolog thereof, as well as a nucleic acid molecule encoding the polypeptide, and compositions thereof. The invention also provi
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Nitro Fatty Acids As Regiomers and Related Mimetics
Mimetics of nitro linoleic acid are potent agonists of PPAR-?, a receptor that regulates adipocyte differentiation, glucose homeostasis and insulin sensitivity. Thus, 10-LNO2 and 12-LN-NO2 are potent, selective activators of the PPAR-?, as are mimetics of LNO2 that bind in a manner similar to LNO2.
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Establishing Compatibility Between Two-and Three Dimensional Optical Coherence Tomography Scans
Advances in optical coherence tomography (OCT) have prompted a transition from time domain OCT, providing 2D OCT images, to spectral domain OCT, which has a 3D imaging capability. Yet conventional technology offers little toward the goal of inter-device compatibility between extant 2D OCT images and
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Marker Panels for Idiopathic Pulmonary Fibrosis Diagnosis and Evaluation
The present invention relates to the discovery that of a panel of serum or plasma markers may be used to diagnose Idiopathic Pulmonary Fibrosis ("IPF") and distinguish this condition from other lung ailments. It further relates to the identification of markers associated with IPF disease progression
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An Echo-specific K-space Reordering Approach to Compatible Dual-echo Arteriovenography
A dual-echo sequence technique provided herein empowers simultaneous acquisition of both TOF MRA and BOLD MRV in a single MR acquisition. By this approach, an echo- specific K-space ordering scheme permits the adjustment of the scan parameters that are compatible for each of the MRA and MRV. The ima
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Peptide Analogs Capable of Enhancing Stimulation of a Glioma-specific Ctl Response
The invention provides a peptide derived from the interleukin-13 receptor alpha2, which serves as a HLA-A2-restricted cytotoxic T lymphocyte (CTL) epitope. The invention can be used as a vaccine for glioma and can be formulated into compositions for medical or veterinary use. In addition, the invent
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System and Method for Real Time Asset Location and Tracking
A system for estimating the current position of an asset within a location that includes a transponder associated with the asset, a plurality of wireless interface devices provided within the location, and a central computer system in electronic communication with the wireless interface devices. The
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Nanoscale Silicon-based Compositions and Methods of Preparation
The present invention is related to nano-particle compositions, methods of their preparation and applications thereof. The nano-particle compositions include silicon-containing nano-particles, a graphite matrix, carbon nanotubes and an amorphous carbon interface formed between the silicon-containing
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Micrornas in Idiopathic Pulmonary Fibrosis
The present invention relates to the discovery that certain microRNAs are differentially expressed in Idiopathic Pulmonary Fibrosis. The present invention provides for diagnostic methods, therapeutic methods, and kits related to these differentially expressed microRNAs.
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Administration of an Adsorbent Polymer for Treatment of Systemic Inflammation
The invention provides a method of ameliorating systemic inflammation in a patient involving administering to the patient a therapeutically effective dose of composition including polystyrene divinyl benzene copolymer and a polyvinyl pyrrolidone polymer. More particularly, the method relates to usin
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Radioprotective Agents
Provided herein are methods, for reducing, preventing, mitigating and treating damage caused by radiation. The methods comprise delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation or to mitigate a
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Cyclic Adenosine Monophosphates for Reducing the Formation of Adhesions
Provided herein are methods of reducing adhesion formation in a subject, for example, post-surgical abdominal and pelvic adhesions. The methods comprise administering to the subject a compound chosen from one or both of 2',3' cyclic adenosine monophosphate, or an analogue or pharmaceutically accepta
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Method and Apparatus for Nondestructive Evaluation and Monitoring of Materials and Structures
A method and apparatus for nondestructive evaluation (NDE) of structures and materials using a highly nonlinear medium for the generation and detection of one or multiple highly nonlinear pulses (or highly nonlinear waves) impinging on a material or structure. The apparatus includes pulse exciters t
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Surfactant-based Antimicrobial Solution for Inhalation
A surfactant can be added, safely and effectively, to a drug solution containing any antimicrobial agent, such as an antibiotic like tobramycin, that is suitable for administration to the lungs via inhalation. Thus, when an aerosolized drug solution includes surfactant, Marangoni flows cause the dru
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Methods for Heat Shock Protein Dependent Cancer Treatment
The present invention provides a method of treating an Hsp70 dependent cancer, including: providing at least one Hsp70 dependent cancer cell; contacting the at least one cell with a sub-effective concentration of a dihydropyrimidinone compound; and contacting the at least one cell with a sub-effecti
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Nitrated-fatty Acids Modulation of Type Ii Diabetes
Nitro oleic acid and related metabolites are agonists of PPAR-?. Surprisingly, nitro oleic acid is a more potent agonist of PPAR-?, relative to nitro linoleic acid. Thus, nitro oleic acid and its metabolites, as well as their pharmaceutically acceptable salts and prodrug forms, are candidate therape
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Manipulation, Detection, and Assay of Small Scale Biological Particles
Systems, devices, and methods are presented that facilitate electronic manipulation and detection of submicron particles. A particle manipulation device contains a plurality of electrodes formed on an active semiconductor layer of an integrated circuit chip, where the electrodes and gap spacing betw
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System and Method for Visualizing a Structure of Interest
A system. The system includes a computing device configured for communication with an imaging system and with a display device. The computing device includes a contour modeling module. The contour modeling module is configured for superimposing reference anchors on a cross-sectional image generated
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Virus Derived Antimicrobial Peptides
Described herein are peptides having antimicrobial activity (antimicrobial peptides). The antimicrobial peptides, designated LBU, WLBU and WR, are analogs of the Lentivirus Lytic Peptide 1 (LLP1) amino acid sequence. The antimicrobial peptides are monomers or multimers of peptides referred to as the
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Powered Vehicle Convoying Systems and Methods of Convoying Powered Vehicles
A vehicle convoy system for use in connection with a vehicle (for example a self-propelled wheelchair), wherein the vehicle includes at least one drive mechanism to impart drive to the vehicle, includes a first processor to effect control of the drive mechanism based upon data of the position of a l
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Electrode Systems, Devices and Methods
An electrode system include a flowable and cohesive surface contact element comprising a hydrophilic polymer swollen with an electrolyte fluid, the contact element having a Q' ratio (A) of at least 5 as defined by the equation wherein WG is the dry weight of the hydrophilic polymer and WW is weight
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Ultrafast Microscopy of Surface Electromagnetic Fields
System(s) and method(s) to probe electromagnetic fields at the surface of a solid-state material are provided. The technique combines ultrafast (e.g., less than 10 fs) optical excitation and electron microscopy to generate electronic excitations and image the ensuing electromagnetic fields with nano
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Implantable Device, System Including Same, and Method Utilizing Same
An implantable device. The implantable device includes a computing device, a microelectromechanical system (MEMS) pH sensor connected to the computing device, and a communication system connected to the computing device.
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Biosensors and Related Methods
Provided herein are biosensors that comprise a biological signal source linked to a substrate by a peptide nucleic acid spacer and methods of use of the biosensor. In one embodiment, the biosensor is used to detect prostate-specific antigen.
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Diagnostic and Therapeutic Uses of Augmenter of Liver Regeneration in Inflammatory Conditions
The present invention provides for methods and kits for detecting sepsis, trauma/hemorrhage or inflammation in a subject. It is based, at least in part, on the discovery that Augmenter of Liver Regeneration ("ALR") is an early marker of these conditions. Accordingly, in other embodiments, the presen
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Method and Software Tool for Automatic Generation of Software for Integrated Circuit
A method of generating software code for a processor of an IC based on a simple input description of the IC's standards. The method includes generating a macros description of each of the primitives from the standards and the response corresponding to each of the primitives, wherein the macros descr
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Electrocardiogram Reconstruction from Implanted Device Electrograms
A method of reconstruction of the standard 12-lead surface EKG given values of the electrical potential from an implanted medical device is described. This implanted device can be oriented in an arbitrary fashion and reconstruction technique is obtained through physical measurement of the orientatio
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Bi-plane X-ray Imaging System
A high-speed biplane radiography system for in-vivo assessment of joint function is provided. The system can acquire stereo-pair radiographic images at rates from 30-4000 frames per second of nearly any motion or joint. The radiographic equipment can be mounted in a gantry system that provides suffi
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Triggerably Dissolvable Hollow Fibers for Controlled Delivery
Provided are tubular structures of a biocompatible, triggerably-dissolvable material such as cellulose or a copolymer having an LCST below physiological temperatures. The structures may be embedded within a cell growth scaffold. The tubular structures are useful in growing 3-dimensional tissue struc
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Suppression of Postoperative Ileus
The invention provides a method for suppressing postoperative ileus in connection with the performance of a surgical procedure on a patient. In accordance with the inventive method, interleukin-10 (IL-10), glycine, a COX-2 inhibitor and a mast cell stabilizer are administered to the patient undergoi
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Engineered Dendritic Cells and Uses for the Treatment of Cancer
This invention provides the field of therapeutics. Most specifically present invention provides methods of generating in vitro engineered dendritic cells conditionally expressing interleukin-12 (IL- 12) under the control of a gene expression modulation system in the presence of activating ligand and
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Automated Assessment of Atrioventricular and Ventriculoatrial Conduction
A method discriminates between ventricular arrhythmia and supraventricular arrhythmia by determining the direction of an electrical signal conducted through the atrioventricular node. An implantable cardiac defibrillator provides atrioventricular and ventriculoatrial pacing bursts to determine if an
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Electric-field Assisted Fuel Atomization System and Methods of Use
An apparatus (100) for reducing the size of fuel particles injected into a combustion chamber is disclosed. The apparatus includes fuel line (110), a first metallic mesh (114) disposed within the fuel line (110), and a second metallic mesh(112) disposed within the fuel line (110), upstream of the fi
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Use of Nibp Polypeptides
Methods for regulating NF-?B activation in cells comprising introducing into the cell a vector comprising a nucleic acid sequence encoding a NIK and IKK2 Binding Protein (NIBP) polypeptide, wherein the NIBP polypeptide is expressed in the cell, are provided. Also provided are methods for reversing t
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Method & apparatus for treatment of fluid
An apparatus for the magnetic treatment of a fluid which produces at least one magnetic field for a period of time, Tc at or above a critical magnetic field strength, Hc, the period Tc and the field strength Hc determined relative to one another and dependant upon the properties of the fluid.
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Blood Monocyte Cd163 Expression As a Biomarker in Hiv-1 Infection and Neuroaids
The invention provides a method for detecting CD163+/CD16+ cell population in peripheral blood mononuclear cells in a biological sample from a subject infected with HIV-1 which comprises contacting the biological sample with an anti-CD163 antibody, so that levels of CD163+/CD16+ peripheral blood mon
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Method for Detecting Disease Markers
Disease specific markers, in particular cancer markers, can be detected by electrophoretically separating proteins and protein complexes from a biological sample on a protein binding polymeric membrane in a low conductivity, water-miscible organic solvent buffer. Electrophoretic separation profiles
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An Assay for Screening/ranking Antioxidants Based on their Effects on Membrane Sterol Lateral Organization
A method of screening an antioxidant for potency and/or toxicity in vitro, the method includes contacting the antioxidant with a model system comprising a sterol superlattice formation capable of generating a detectible signal, wherein the detectible signal changes in a parameter representative of a
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Manipulating Sp1 Activity to Improve Therapeutic Cloning
The observed over-expression of Sp1 target genes has inspired inventors to formulate a specific strategy for correcting many gene expression defects, and thus improve clone development. The invention is based on the belief that manipulating Sp1 activity can improve cloning. Inventors believe that cl
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Leptin Agonist and Methods of Use
Peptides are provided having leptin receptor agonist activity. The peptides are useful for treating obesity, insulin resistance, lipodystrophy and hypothalamic amenorrhea, anorexia-related infertility, among other diseases and conditions related to leptin deficiency and/or leptin resistance.
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Antibacterial Peptides Active in Systemic Infections
Antimicrobial peptides of the formula are provided: X1-X2-PrO- X3- X4-PrO- Arg- Pro-Tyr-Leu-Pro- X5-Pro-Arg-Pro-Pro-Arg-Pro-Y, wherein X1 is a natural or non-natural amino acid having a free amino group or 1-amino-cyclohexyl carboxylic acid, X2 is Arg or N-methyl-Arg, X3 is Asp or GIu, X4 is Arg or
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Methods and Devices for Generation of Broadband Pulsed Radiation
Methods and apparatus for non-collinear optical parametric amplification (NOPA) are provided. Broadband phase matching is achieved with a non-collinear geometry and a divergent signal seed to provide bandwidth gain. A chirp may be introduced into the pump pulse such that the white light seed is ampl
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Treatment of proliferative disorders with amino-substituted (E)-2,6- dialkoxystyryl 4-substituted benzylsulfones
Methods of treating cancer using compounds according to Formula (I) are disclosed herein, wherein X, X1, X2, Ra, R1, R2, R3, R4, R5, R6, R7, g, M, y, a, b, d, e, V, W, Z and Q are as defined herein.
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Synthesis of Bis-peptides Oligomers Comprising At Least One N-substituted Diketopiperazine As Structural Moiety
Functionalized bis-peptides as well as other amide-containing compounds are obtained by acylation of hindered amines. The functionalized bis-peptides are useful as shape-programmable nanostructures that are immune to denaturation and that contain arrays of functional groups having designed catalytic
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Composite Bone Grafts, Particulate Bone-calcium Sulfate Constructs, and Methods of Treating Joint Injuries
A solid implantable bone construct (12) shaped like a cylinder, a cone, or a frustum, for anchoring ligament implants. The bone construct (12) can include a bone component and a biocompatible solid component. The bone component can include particulate bone of between 75 and 600 microns, powdered bon
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Obesity Controlling Method
A method of controlling obesity by injecting bio-compatible bulking material into the pyloric sphincter area of the stomach. The injection of this material bulks the pyloric sphincter, retarding stomach emptying and producing a feeling of satiation in the patient. The method may be supplemental and
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